Nerve growth factor inducible (VGF) is a secreted mediator for metastatic breast cancer tropism to the brain

Brain metastases are one of the most serious clinical problems in breast cancer (BC) progression, associated with lower survival rates and a lack of effective therapies. Thus, to dissect the early stages of the brain metastatic process, we studied the impact of brain organotropic BC cells’ secretome...

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Veröffentlicht in:	The Journal of pathology 2024-10, Vol.264 (2), p.132-147
Hauptverfasser:	Carvalho, Rita, Santos, Liliana, Conde, Inês, Leitão, Ricardo, Ferreira, Hugo RS, Gomes, Célia, Silva, Ana Paula, Schmitt, Fernando, Carvalho‐Maia, Carina, Lobo, João, Jerónimo, Carmen, Paredes, Joana, Ribeiro, Ana Sofia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blood-brain barrier Blood-Brain Barrier - metabolism Brain Neoplasms - metabolism Brain Neoplasms - secondary brain pre‐metastatic niche brain signature Brain tumors Breast cancer breast cancer brain metastasis Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor ErbB-2 protein Female Growth factors Humans Medical prognosis Metastases Metastasis Mice microglia Microglia - metabolism Microglia - pathology Nerve growth factor Prognosis prognostic biomarker Secretome Stroma Tropism Tumors VGF
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