Candidaantarctica Lipase B mediated kinetic resolution: A sustainable method for chiral synthesis of antiproliferative β-lactams

Biocatalysis is a valuable industrial approach in active pharmaceutical ingredient (API) manufacturing for asymmetric induction and synthesis of chiral APIs. Herein, we investigated synthesis of a panel of microtubule-destabilising antiproliferative β-lactam enantiomers employing a commercially avai...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-10, Vol.276, p.116692, Article 116692
Hauptverfasser:	McLoughlin, Eavan C., Twamley, Brendan, O'Boyle, Niamh M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferative Basidiomycota Beta-lactams beta-Lactams - chemical synthesis beta-Lactams - chemistry beta-Lactams - pharmacology Biocatalysis Cell Proliferation - drug effects Chiral resolution Dose-Response Relationship, Drug Enantiomers Fungal Proteins - antagonists & inhibitors Fungal Proteins - metabolism Humans Kinetics Lipase Lipase - metabolism Molecular Structure Stereoisomerism Structure-Activity Relationship
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