CYB5R3 overexpression exhibits sexual dimorphism: Mitochondrial and metabolic adaptations in transgenic female mice during calorie restriction

There is a pressing need to develop new strategies for enhancing health in the elderly and preventing the rise in age-related diseases. Calorie restriction without malnutrition (CR) stands among the different antiaging interventions. Lifelong CR leads to increased expression and activity of plasma m...

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Veröffentlicht in:	Free radical biology & medicine 2024-10, Vol.223, p.69-86
Hauptverfasser:	Sánchez-Mendoza, Luz Marina, Pérez-Sánchez, Carlos, García-Caballero, Cristina, Pérez-Rodríguez, Miguel, Calero-Rodríguez, Pilar, Vellón-García, Beatriz, Moreno, Juan Antonio, Burón, M. Isabel, de Cabo, Rafael, González-Reyes, José A., Villalba, José M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Caloric Restriction Calorie restriction Cytochrome b5 reductase Cytochrome-B Reductase - genetics Cytochrome-B Reductase - metabolism Energy Metabolism - genetics Female Liver Liver - metabolism Male Mice Mice, Transgenic Mitochondria Mitochondria - genetics Mitochondria - metabolism Muscle, Skeletal - metabolism Oxidative Stress Sex Characteristics Sexual dimorphism Skeletal muscle
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