CXCL5 expression is associated with active signals of macrophages in the microenvironment of papillary thyroid carcinoma
C-X-C motif chemokine ligand 5 (CXCL5) is a chemokine molecule that is secreted by immune cells in attracting granulocytes. Studies showed that CXCL5 was related to the progression of papillary thyroid carcinoma (PTC) tumor cells. However, the in vivo effects of CXCL5 on PTC tumor cells and their mi...
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| description | C-X-C motif chemokine ligand 5 (CXCL5) is a chemokine molecule that is secreted by immune cells in attracting granulocytes. Studies showed that CXCL5 was related to the progression of papillary thyroid carcinoma (PTC) tumor cells. However, the in vivo effects of CXCL5 on PTC tumor cells and their microenvironment have not been elucidated. The present study aimed to investigate the biological effects of CXCL5 on tumor cells, microenvironment, and clinical progression of PTC.
The PTC patients from The Human Cancer Genome Atlas (TCGA) – thyroid carcinoma (THCA) were retrieved. There were a total of 500 patients who met the criteria of our study. Differential expression (DEA) and pathway analyses were used to explore the biological effects of CXCL5 gene expression.
In DEA, we found that CXCL5 was mostly associated with PBPP, SLC11A1, and MRC1 (adjusted p |
| doi_str_mv | 10.1016/j.prp.2024.155474 |
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The PTC patients from The Human Cancer Genome Atlas (TCGA) – thyroid carcinoma (THCA) were retrieved. There were a total of 500 patients who met the criteria of our study. Differential expression (DEA) and pathway analyses were used to explore the biological effects of CXCL5 gene expression.
In DEA, we found that CXCL5 was mostly associated with PBPP, SLC11A1, and MRC1 (adjusted p<0.001). Samples with CXCL5 FPKM≥1 were related to a different immune profile (p<0.001). In pathway analyses, samples with higher CXCL5 expression possessed higher activities of RAS-RAF, NF-kB, PRC2, IL2, IL5, and Wnt pathways (adjusted p<0.001). In microenvironment analysis, CXCL5 was highly correlated with the activity of macrophage (Rho=0.76; adjusted p<0.001). Clinically, high level of CXCL5 expression was an indicator of tumor stages (p<0.001), nodal metastasis (AUC=0.68), and prognosis (p=0.001).
CXCL5 was a significant biomarker of PTC. CXCL5 was highly associated with tumor immunology and microenvironment. Samples with higher CXCL5 expression had more advanced disease status and worse prognosis. CXCL5 target therapy is potentially helpful in advanced PTC.</description><identifier>ISSN: 0344-0338</identifier><identifier>ISSN: 1618-0631</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2024.155474</identifier><identifier>PMID: 39067172</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Chemokine ; Chemokine CXCL5 - genetics ; Chemokine CXCL5 - metabolism ; CXCL5 ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Macrophages ; Macrophages - immunology ; Macrophages - metabolism ; Macrophages - pathology ; Male ; Middle Aged ; Papillary thyroid carcinoma ; Prognosis ; Signal Transduction ; Thyroid Cancer, Papillary - genetics ; Thyroid Cancer, Papillary - immunology ; Thyroid Cancer, Papillary - metabolism ; Thyroid Cancer, Papillary - pathology ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - immunology ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Tumor immune ; Tumor microenvironment ; Tumor Microenvironment - immunology ; Tumor-Associated Macrophages - immunology ; Tumor-Associated Macrophages - metabolism ; Tumor-Associated Macrophages - pathology</subject><ispartof>Pathology, research and practice, 2024-09, Vol.261, p.155474, Article 155474</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c235t-f82786a2e2102ec174af9aeb81f61d781ef67dfbee4fe53fe318f7a184441f5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0344033824003856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39067172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le, Tho Ngoc-Quynh</creatorcontrib><creatorcontrib>Le, Minh-Khang</creatorcontrib><creatorcontrib>Dang, Minh-Xuan</creatorcontrib><creatorcontrib>Kondo, Tetsuo</creatorcontrib><title>CXCL5 expression is associated with active signals of macrophages in the microenvironment of papillary thyroid carcinoma</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>C-X-C motif chemokine ligand 5 (CXCL5) is a chemokine molecule that is secreted by immune cells in attracting granulocytes. Studies showed that CXCL5 was related to the progression of papillary thyroid carcinoma (PTC) tumor cells. However, the in vivo effects of CXCL5 on PTC tumor cells and their microenvironment have not been elucidated. The present study aimed to investigate the biological effects of CXCL5 on tumor cells, microenvironment, and clinical progression of PTC.
The PTC patients from The Human Cancer Genome Atlas (TCGA) – thyroid carcinoma (THCA) were retrieved. There were a total of 500 patients who met the criteria of our study. Differential expression (DEA) and pathway analyses were used to explore the biological effects of CXCL5 gene expression.
In DEA, we found that CXCL5 was mostly associated with PBPP, SLC11A1, and MRC1 (adjusted p<0.001). Samples with CXCL5 FPKM≥1 were related to a different immune profile (p<0.001). In pathway analyses, samples with higher CXCL5 expression possessed higher activities of RAS-RAF, NF-kB, PRC2, IL2, IL5, and Wnt pathways (adjusted p<0.001). In microenvironment analysis, CXCL5 was highly correlated with the activity of macrophage (Rho=0.76; adjusted p<0.001). Clinically, high level of CXCL5 expression was an indicator of tumor stages (p<0.001), nodal metastasis (AUC=0.68), and prognosis (p=0.001).
CXCL5 was a significant biomarker of PTC. CXCL5 was highly associated with tumor immunology and microenvironment. Samples with higher CXCL5 expression had more advanced disease status and worse prognosis. CXCL5 target therapy is potentially helpful in advanced PTC.</description><subject>Adult</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Chemokine</subject><subject>Chemokine CXCL5 - genetics</subject><subject>Chemokine CXCL5 - metabolism</subject><subject>CXCL5</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Macrophages</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Papillary thyroid carcinoma</subject><subject>Prognosis</subject><subject>Signal Transduction</subject><subject>Thyroid Cancer, Papillary - genetics</subject><subject>Thyroid Cancer, Papillary - immunology</subject><subject>Thyroid Cancer, Papillary - metabolism</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - immunology</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Tumor immune</subject><subject>Tumor microenvironment</subject><subject>Tumor Microenvironment - immunology</subject><subject>Tumor-Associated Macrophages - immunology</subject><subject>Tumor-Associated Macrophages - metabolism</subject><subject>Tumor-Associated Macrophages - pathology</subject><issn>0344-0338</issn><issn>1618-0631</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJady0P6CXomMu62pW2pVCT8H0I2DopYXehKwdxWO8K1VaO8m_r4zTHHsaGJ73ZeZh7AOIJQjoP-2WKadlK1q1hK5TWr1iC-jBNKKXcMEWQirVCCnNJXtbyk4IoYWCN-xS3oheg24X7HH1e7XuOD6mjKVQnDgV7kqJntyMA3-gecudn-mIvND95PaFx8BH53NMW3ePhdPE5y3ykeoKpyPlOI04zScsuUT7vctPlXjKkQbuXfY0xdG9Y69DLcP3z_OK_fr65efqe7P-8e1udbtufCu7uQmm1aZ3LbYgWvSglQs3DjcGQg-DNoCh10PYIKqAnQwowQTtwCilIHROXrHrc2_K8c8By2xHKh7rVRPGQ7FSmK43XfVRUTij9ZFSMgabMo31egvCnoTbXd0kexJuz8Jr5uNz_WEz4vCS-Ge4Ap_PANYnj4TZFk84eRwoo5_tEOk_9X8BNFKTfw</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Le, Tho Ngoc-Quynh</creator><creator>Le, Minh-Khang</creator><creator>Dang, Minh-Xuan</creator><creator>Kondo, Tetsuo</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202409</creationdate><title>CXCL5 expression is associated with active signals of macrophages in the microenvironment of papillary thyroid carcinoma</title><author>Le, Tho Ngoc-Quynh ; Le, Minh-Khang ; Dang, Minh-Xuan ; Kondo, Tetsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-f82786a2e2102ec174af9aeb81f61d781ef67dfbee4fe53fe318f7a184441f5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Chemokine</topic><topic>Chemokine CXCL5 - genetics</topic><topic>Chemokine CXCL5 - metabolism</topic><topic>CXCL5</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Macrophages</topic><topic>Macrophages - immunology</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Papillary thyroid carcinoma</topic><topic>Prognosis</topic><topic>Signal Transduction</topic><topic>Thyroid Cancer, Papillary - genetics</topic><topic>Thyroid Cancer, Papillary - immunology</topic><topic>Thyroid Cancer, Papillary - metabolism</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - immunology</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Tumor immune</topic><topic>Tumor microenvironment</topic><topic>Tumor Microenvironment - immunology</topic><topic>Tumor-Associated Macrophages - immunology</topic><topic>Tumor-Associated Macrophages - metabolism</topic><topic>Tumor-Associated Macrophages - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le, Tho Ngoc-Quynh</creatorcontrib><creatorcontrib>Le, Minh-Khang</creatorcontrib><creatorcontrib>Dang, Minh-Xuan</creatorcontrib><creatorcontrib>Kondo, Tetsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le, Tho Ngoc-Quynh</au><au>Le, Minh-Khang</au><au>Dang, Minh-Xuan</au><au>Kondo, Tetsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CXCL5 expression is associated with active signals of macrophages in the microenvironment of papillary thyroid carcinoma</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2024-09</date><risdate>2024</risdate><volume>261</volume><spage>155474</spage><pages>155474-</pages><artnum>155474</artnum><issn>0344-0338</issn><issn>1618-0631</issn><eissn>1618-0631</eissn><abstract>C-X-C motif chemokine ligand 5 (CXCL5) is a chemokine molecule that is secreted by immune cells in attracting granulocytes. Studies showed that CXCL5 was related to the progression of papillary thyroid carcinoma (PTC) tumor cells. However, the in vivo effects of CXCL5 on PTC tumor cells and their microenvironment have not been elucidated. The present study aimed to investigate the biological effects of CXCL5 on tumor cells, microenvironment, and clinical progression of PTC.
The PTC patients from The Human Cancer Genome Atlas (TCGA) – thyroid carcinoma (THCA) were retrieved. There were a total of 500 patients who met the criteria of our study. Differential expression (DEA) and pathway analyses were used to explore the biological effects of CXCL5 gene expression.
In DEA, we found that CXCL5 was mostly associated with PBPP, SLC11A1, and MRC1 (adjusted p<0.001). Samples with CXCL5 FPKM≥1 were related to a different immune profile (p<0.001). In pathway analyses, samples with higher CXCL5 expression possessed higher activities of RAS-RAF, NF-kB, PRC2, IL2, IL5, and Wnt pathways (adjusted p<0.001). In microenvironment analysis, CXCL5 was highly correlated with the activity of macrophage (Rho=0.76; adjusted p<0.001). Clinically, high level of CXCL5 expression was an indicator of tumor stages (p<0.001), nodal metastasis (AUC=0.68), and prognosis (p=0.001).
CXCL5 was a significant biomarker of PTC. CXCL5 was highly associated with tumor immunology and microenvironment. Samples with higher CXCL5 expression had more advanced disease status and worse prognosis. CXCL5 target therapy is potentially helpful in advanced PTC.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>39067172</pmid><doi>10.1016/j.prp.2024.155474</doi></addata></record> |
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| subjects | Adult Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Chemokine Chemokine CXCL5 - genetics Chemokine CXCL5 - metabolism CXCL5 Female Gene Expression Regulation, Neoplastic Humans Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Middle Aged Papillary thyroid carcinoma Prognosis Signal Transduction Thyroid Cancer, Papillary - genetics Thyroid Cancer, Papillary - immunology Thyroid Cancer, Papillary - metabolism Thyroid Cancer, Papillary - pathology Thyroid Neoplasms - genetics Thyroid Neoplasms - immunology Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Tumor immune Tumor microenvironment Tumor Microenvironment - immunology Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism Tumor-Associated Macrophages - pathology |
| title | CXCL5 expression is associated with active signals of macrophages in the microenvironment of papillary thyroid carcinoma |
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