Partial protein binding of uracil and thymine affects accurate dihydropyrimidine dehydrogenase (DPD) phenotyping

Fluorouracil is among the most used antimetabolite drugs for the chemotherapeutic treatment of various types of gastrointestinal malignancies. Dihydropyrimidine dehydrogenase (DPYD) genotyping prior to fluorouracil treatment is considered standard practice in most European countries. Yet, current pr...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2024-10, Vol.249, p.116381, Article 116381
Hauptverfasser:	van den Wildenberg, Sebastian A.H., Genet, Sylvia A.A.M., Streng, Alexander S., Broeren, Maarten A.C., Deenen, Maarten J., van Dongen, Joost L.J., Brunsveld, Luc, Scharnhorst, Volkher, van de Kerkhof, Daan
Format:	Artikel
Sprache:	eng
Schlagworte:	Dihydropyrimidine Dehydrogenase Activity Protein Binding Protein Precipitation Protein Ultrafiltration Thymine Uracil
Online-Zugang:	Volltext
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