Development of non-acidic 4-methylbenzenesulfonate-based aldose reductase inhibitors; Design, Synthesis, Biological evaluation and in-silicostudies

[Display omitted] •A series of non-acidic 4-methylbenzenesulfonate-based ALR2 inhibitors were designed.•Molecular docking was utilized for virtual screening to identify suitable candidates.•Seventeen new compounds were chosen for synthesis and biological evaluation.•In vivo studies were conducted fo...

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