The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression
(L.) Kuntze is a traditional herb with multiple medicinal properties and with potential for preventing or treating various diseases. Acteoside, one of the active ingredients in , is prepared into commercially available products of A. indica HP813 powder. In this study, the gastroprotective effects o...
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| Veröffentlicht in: | Nutrients 2024-07, Vol.16 (14), p.2297 |
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| creator | Chen, Yu-Ru Lien, Hsiu-Man Tsai, Fuu-Jen Liao, Jiunn-Wang Chen, Yng-Tay |
| description | (L.) Kuntze is a traditional herb with multiple medicinal properties and with potential for preventing or treating various diseases. Acteoside, one of the active ingredients in
, is prepared into commercially available products of A. indica HP813 powder. In this study, the gastroprotective effects of
HP813 powder were evaluated. Wistar rats were treated with
HP813 powder at doses of 0, 207.5, 415, and 830 mg/kg body weight for 28 days. Then, gastric ulcers were induced by the oral administration of 70% ethanol (10 mL/kg body weight) on day 28. The rats were sacrificed at the end of the trial, and stomach tissues were collected. These stomach tissues were then used for macroscopic, microscopic, and immunohistochemical analyses. The results indicated that the area of gastric ulcer was 48.61%, 35.30%, and 27.16% in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. In addition, the lesion scores were 2.9, 2.4, and 2.3 in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. The immunochemical staining of the gastric tissue revealed that
HP813 powder reduced the expressions of TNF-α and NF-κB proteins in the gastric tissue, which had been induced by ethanol. Finally,
HP813 powder protected the gastric ulcer from ethanol damage through IκB-α induction. The present results demonstrated that
HP813 powder has protective effects against ethanol-induced gastric ulcer. |
| doi_str_mv | 10.3390/nu16142297 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3085119128</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3085119128</sourcerecordid><originalsourceid>FETCH-LOGICAL-c273t-af6e52752a31f7fc582c29383f6a1a27d6445f863dffa2618a812e83b476377f3</originalsourceid><addsrcrecordid>eNqFkU1OHDEQhS1EFBCwyQEiS9mgSA3-6bY9SzIayEiIbGDd8rjLtFGPPdhulNwmV2DLIThTPMxAUDapTZX8vnqS6yH0iZITzifk1I9U0JqxidxB-4xIVglR89138x46SumOrEsSKfhHtFcWRS1rso9-X_eAL3TKMaxiyGCyewA8s7ZMCQeLz7xLYQkDJOx854zG-lY7nzKe5V77MFRz340Guo2LM_hmMBBx7mMYb_vSAb8Q2QW_Npw_P32rnh-x9t1W7N3CvapX51XR8eznKkJK5fEQfbB6SHC07Qfo5nx2Pf1eXf64mE_PLivDJM-VtgIaJhumObXSmkYxwyZccSs01Ux2oq4bqwTvrNVMUKUVZaD4oi4XkdLyA3S88S1nuB8h5XbpkoFh0B7CmFpOGy6pIg35P0pUQ-mEMlXQL_-gd2GMvnzkhSKUC1YX6uuGMjGkFMG2q-iWOv5qKWnXKbd_Uy7w563luFhC94a-Zsr_ANI4o5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3085013624</pqid></control><display><type>article</type><title>The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Chen, Yu-Ru ; Lien, Hsiu-Man ; Tsai, Fuu-Jen ; Liao, Jiunn-Wang ; Chen, Yng-Tay</creator><creatorcontrib>Chen, Yu-Ru ; Lien, Hsiu-Man ; Tsai, Fuu-Jen ; Liao, Jiunn-Wang ; Chen, Yng-Tay</creatorcontrib><description>(L.) Kuntze is a traditional herb with multiple medicinal properties and with potential for preventing or treating various diseases. Acteoside, one of the active ingredients in
, is prepared into commercially available products of A. indica HP813 powder. In this study, the gastroprotective effects of
HP813 powder were evaluated. Wistar rats were treated with
HP813 powder at doses of 0, 207.5, 415, and 830 mg/kg body weight for 28 days. Then, gastric ulcers were induced by the oral administration of 70% ethanol (10 mL/kg body weight) on day 28. The rats were sacrificed at the end of the trial, and stomach tissues were collected. These stomach tissues were then used for macroscopic, microscopic, and immunohistochemical analyses. The results indicated that the area of gastric ulcer was 48.61%, 35.30%, and 27.16% in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. In addition, the lesion scores were 2.9, 2.4, and 2.3 in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. The immunochemical staining of the gastric tissue revealed that
HP813 powder reduced the expressions of TNF-α and NF-κB proteins in the gastric tissue, which had been induced by ethanol. Finally,
HP813 powder protected the gastric ulcer from ethanol damage through IκB-α induction. The present results demonstrated that
HP813 powder has protective effects against ethanol-induced gastric ulcer.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16142297</identifier><identifier>PMID: 39064740</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alcohol ; Animals ; Anisomeles indica ; Anti-Ulcer Agents - pharmacology ; Antibodies ; body weight ; Cytokines ; Drug dosages ; Ethanol ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; immunohistochemistry ; Inflammation ; Laboratory animals ; Male ; Neutrophils ; NF-kappa B - metabolism ; NF-KappaB Inhibitor alpha - metabolism ; oral administration ; Plant Extracts - pharmacology ; Powders ; Quantitative analysis ; Rats ; Rats, Wistar ; Stomach ; Stomach Ulcer - chemically induced ; Stomach Ulcer - drug therapy ; Stomach Ulcer - metabolism ; Stomach Ulcer - prevention & control ; stomach ulcers ; Tumor necrosis factor-TNF ; Ulcers</subject><ispartof>Nutrients, 2024-07, Vol.16 (14), p.2297</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c273t-af6e52752a31f7fc582c29383f6a1a27d6445f863dffa2618a812e83b476377f3</cites><orcidid>0000-0001-7374-1203 ; 0000-0002-2007-3974 ; 0000-0002-5466-7674</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39064740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yu-Ru</creatorcontrib><creatorcontrib>Lien, Hsiu-Man</creatorcontrib><creatorcontrib>Tsai, Fuu-Jen</creatorcontrib><creatorcontrib>Liao, Jiunn-Wang</creatorcontrib><creatorcontrib>Chen, Yng-Tay</creatorcontrib><title>The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>(L.) Kuntze is a traditional herb with multiple medicinal properties and with potential for preventing or treating various diseases. Acteoside, one of the active ingredients in
, is prepared into commercially available products of A. indica HP813 powder. In this study, the gastroprotective effects of
HP813 powder were evaluated. Wistar rats were treated with
HP813 powder at doses of 0, 207.5, 415, and 830 mg/kg body weight for 28 days. Then, gastric ulcers were induced by the oral administration of 70% ethanol (10 mL/kg body weight) on day 28. The rats were sacrificed at the end of the trial, and stomach tissues were collected. These stomach tissues were then used for macroscopic, microscopic, and immunohistochemical analyses. The results indicated that the area of gastric ulcer was 48.61%, 35.30%, and 27.16% in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. In addition, the lesion scores were 2.9, 2.4, and 2.3 in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. The immunochemical staining of the gastric tissue revealed that
HP813 powder reduced the expressions of TNF-α and NF-κB proteins in the gastric tissue, which had been induced by ethanol. Finally,
HP813 powder protected the gastric ulcer from ethanol damage through IκB-α induction. The present results demonstrated that
HP813 powder has protective effects against ethanol-induced gastric ulcer.</description><subject>Alcohol</subject><subject>Animals</subject><subject>Anisomeles indica</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Antibodies</subject><subject>body weight</subject><subject>Cytokines</subject><subject>Drug dosages</subject><subject>Ethanol</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>immunohistochemistry</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Neutrophils</subject><subject>NF-kappa B - metabolism</subject><subject>NF-KappaB Inhibitor alpha - metabolism</subject><subject>oral administration</subject><subject>Plant Extracts - pharmacology</subject><subject>Powders</subject><subject>Quantitative analysis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stomach</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - metabolism</subject><subject>Stomach Ulcer - prevention & control</subject><subject>stomach ulcers</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ulcers</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkU1OHDEQhS1EFBCwyQEiS9mgSA3-6bY9SzIayEiIbGDd8rjLtFGPPdhulNwmV2DLIThTPMxAUDapTZX8vnqS6yH0iZITzifk1I9U0JqxidxB-4xIVglR89138x46SumOrEsSKfhHtFcWRS1rso9-X_eAL3TKMaxiyGCyewA8s7ZMCQeLz7xLYQkDJOx854zG-lY7nzKe5V77MFRz340Guo2LM_hmMBBx7mMYb_vSAb8Q2QW_Npw_P32rnh-x9t1W7N3CvapX51XR8eznKkJK5fEQfbB6SHC07Qfo5nx2Pf1eXf64mE_PLivDJM-VtgIaJhumObXSmkYxwyZccSs01Ux2oq4bqwTvrNVMUKUVZaD4oi4XkdLyA3S88S1nuB8h5XbpkoFh0B7CmFpOGy6pIg35P0pUQ-mEMlXQL_-gd2GMvnzkhSKUC1YX6uuGMjGkFMG2q-iWOv5qKWnXKbd_Uy7w563luFhC94a-Zsr_ANI4o5Q</recordid><startdate>20240717</startdate><enddate>20240717</enddate><creator>Chen, Yu-Ru</creator><creator>Lien, Hsiu-Man</creator><creator>Tsai, Fuu-Jen</creator><creator>Liao, Jiunn-Wang</creator><creator>Chen, Yng-Tay</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-7374-1203</orcidid><orcidid>https://orcid.org/0000-0002-2007-3974</orcidid><orcidid>https://orcid.org/0000-0002-5466-7674</orcidid></search><sort><creationdate>20240717</creationdate><title>The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression</title><author>Chen, Yu-Ru ; Lien, Hsiu-Man ; Tsai, Fuu-Jen ; Liao, Jiunn-Wang ; Chen, Yng-Tay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-af6e52752a31f7fc582c29383f6a1a27d6445f863dffa2618a812e83b476377f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alcohol</topic><topic>Animals</topic><topic>Anisomeles indica</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Antibodies</topic><topic>body weight</topic><topic>Cytokines</topic><topic>Drug dosages</topic><topic>Ethanol</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - pathology</topic><topic>immunohistochemistry</topic><topic>Inflammation</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Neutrophils</topic><topic>NF-kappa B - metabolism</topic><topic>NF-KappaB Inhibitor alpha - metabolism</topic><topic>oral administration</topic><topic>Plant Extracts - pharmacology</topic><topic>Powders</topic><topic>Quantitative analysis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stomach</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - metabolism</topic><topic>Stomach Ulcer - prevention & control</topic><topic>stomach ulcers</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yu-Ru</creatorcontrib><creatorcontrib>Lien, Hsiu-Man</creatorcontrib><creatorcontrib>Tsai, Fuu-Jen</creatorcontrib><creatorcontrib>Liao, Jiunn-Wang</creatorcontrib><creatorcontrib>Chen, Yng-Tay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yu-Ru</au><au>Lien, Hsiu-Man</au><au>Tsai, Fuu-Jen</au><au>Liao, Jiunn-Wang</au><au>Chen, Yng-Tay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2024-07-17</date><risdate>2024</risdate><volume>16</volume><issue>14</issue><spage>2297</spage><pages>2297-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>(L.) Kuntze is a traditional herb with multiple medicinal properties and with potential for preventing or treating various diseases. Acteoside, one of the active ingredients in
, is prepared into commercially available products of A. indica HP813 powder. In this study, the gastroprotective effects of
HP813 powder were evaluated. Wistar rats were treated with
HP813 powder at doses of 0, 207.5, 415, and 830 mg/kg body weight for 28 days. Then, gastric ulcers were induced by the oral administration of 70% ethanol (10 mL/kg body weight) on day 28. The rats were sacrificed at the end of the trial, and stomach tissues were collected. These stomach tissues were then used for macroscopic, microscopic, and immunohistochemical analyses. The results indicated that the area of gastric ulcer was 48.61%, 35.30%, and 27.16% in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. In addition, the lesion scores were 2.9, 2.4, and 2.3 in the ethanol-induced group, 415 mg/kg
HP813 powder group, and 830 mg/kg
HP813 powder group, respectively. The immunochemical staining of the gastric tissue revealed that
HP813 powder reduced the expressions of TNF-α and NF-κB proteins in the gastric tissue, which had been induced by ethanol. Finally,
HP813 powder protected the gastric ulcer from ethanol damage through IκB-α induction. The present results demonstrated that
HP813 powder has protective effects against ethanol-induced gastric ulcer.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39064740</pmid><doi>10.3390/nu16142297</doi><orcidid>https://orcid.org/0000-0001-7374-1203</orcidid><orcidid>https://orcid.org/0000-0002-2007-3974</orcidid><orcidid>https://orcid.org/0000-0002-5466-7674</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Alcohol Animals Anisomeles indica Anti-Ulcer Agents - pharmacology Antibodies body weight Cytokines Drug dosages Ethanol Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology immunohistochemistry Inflammation Laboratory animals Male Neutrophils NF-kappa B - metabolism NF-KappaB Inhibitor alpha - metabolism oral administration Plant Extracts - pharmacology Powders Quantitative analysis Rats Rats, Wistar Stomach Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - metabolism Stomach Ulcer - prevention & control stomach ulcers Tumor necrosis factor-TNF Ulcers |
| title | The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression |
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