Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes
The aim of this study was to compare thiol/disulfide homeostasis and clinical parameters of rosacea patients across skin subtypes of the disease and healthy controls. This prospective study included 90 rosacea patients with different skin subtypes (phymatous, erythematotelangiectatic and papulopustu...
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| Veröffentlicht in: | Journal of clinical medicine 2024-07, Vol.13 (14), p.4052 |
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| creator | Yesilirmak, Nilufer Saritas, Ozge Kurt, Busra Neselioglu, Salim Aktas, Akin Erel, Ozcan |
| description | The aim of this study was to compare thiol/disulfide homeostasis and clinical parameters of rosacea patients across skin subtypes of the disease and healthy controls.
This prospective study included 90 rosacea patients with different skin subtypes (phymatous, erythematotelangiectatic and papulopustular) and ocular involvement and 30 healthy controls. Plasma native thiol (NT), total thiol (TT) and disulfide levels of the patients and controls were measured using an automated spectrophotometric method, and disulfide/native thiol ratio (DNTR), disulfide/total thiol ratio (DTTR) and native thiol/total thiol ratio (NTTR) were calculated. Tear breakup time (TBUT), meiboscore, Schirmer, ocular surface disease index (OSDI) and rosacea-specific quality of life scale (RosaQoL) were measured clinically.
Disulfide, DNTR and DTTR were significantly higher, and NT, TT and NTTR were significantly lower in the rosacea patients compared to the controls (
< 0.001). TBUT and Schirmer were significantly lower, and meiboscore and OSDI were significantly higher in the patients compared to the controls (
< 0.01). According to the skin subtypes, disulfide, DNTR and DTTR were significantly higher, and NTTR was significantly lower in the erythematotelangiectatic subtype compared to the other subtypes (
< 0.002). TBUT was significantly lower, and RosaQol was significantly higher in the erythematotelangiectatic subtype (
< 0.0083). Strong correlations were found between DNTR and TBUT and between DNTR and Meiboscore in all subtypes (
< 0.005), while there were strong correlations between DNTR and OSDI and between DNTR and RosaQol only in the erythematotelangiectatic and papulopustular subtypes (
< 0.05).
The thiol/disulfide homeostasis shifted towards disulfides, an indicator of oxidative stress in rosacea, and this was more pronounced in the erythematotelangiectatic subtype. The impairment in TBUT and RosaQol was also more prominent in the erythematotelangiectatic subtype and strongly associated with the DNTR. |
| doi_str_mv | 10.3390/jcm13144052 |
| format | Article |
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This prospective study included 90 rosacea patients with different skin subtypes (phymatous, erythematotelangiectatic and papulopustular) and ocular involvement and 30 healthy controls. Plasma native thiol (NT), total thiol (TT) and disulfide levels of the patients and controls were measured using an automated spectrophotometric method, and disulfide/native thiol ratio (DNTR), disulfide/total thiol ratio (DTTR) and native thiol/total thiol ratio (NTTR) were calculated. Tear breakup time (TBUT), meiboscore, Schirmer, ocular surface disease index (OSDI) and rosacea-specific quality of life scale (RosaQoL) were measured clinically.
Disulfide, DNTR and DTTR were significantly higher, and NT, TT and NTTR were significantly lower in the rosacea patients compared to the controls (
< 0.001). TBUT and Schirmer were significantly lower, and meiboscore and OSDI were significantly higher in the patients compared to the controls (
< 0.01). According to the skin subtypes, disulfide, DNTR and DTTR were significantly higher, and NTTR was significantly lower in the erythematotelangiectatic subtype compared to the other subtypes (
< 0.002). TBUT was significantly lower, and RosaQol was significantly higher in the erythematotelangiectatic subtype (
< 0.0083). Strong correlations were found between DNTR and TBUT and between DNTR and Meiboscore in all subtypes (
< 0.005), while there were strong correlations between DNTR and OSDI and between DNTR and RosaQol only in the erythematotelangiectatic and papulopustular subtypes (
< 0.05).
The thiol/disulfide homeostasis shifted towards disulfides, an indicator of oxidative stress in rosacea, and this was more pronounced in the erythematotelangiectatic subtype. The impairment in TBUT and RosaQol was also more prominent in the erythematotelangiectatic subtype and strongly associated with the DNTR.]]></description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13144052</identifier><identifier>PMID: 39064093</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Automation ; Chemical bonds ; Disease ; Gender ; Homeostasis ; Hydrogen ; Oxidative stress ; Pathogenesis ; Quality of life ; Questionnaires ; Rosacea</subject><ispartof>Journal of clinical medicine, 2024-07, Vol.13 (14), p.4052</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c205t-19454bd36d7ee703b11bbb5d4841dd775b0c648e099aa56828ac496b07d98da3</cites><orcidid>0000-0002-2996-3236 ; 0000-0002-8632-2873</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39064093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yesilirmak, Nilufer</creatorcontrib><creatorcontrib>Saritas, Ozge</creatorcontrib><creatorcontrib>Kurt, Busra</creatorcontrib><creatorcontrib>Neselioglu, Salim</creatorcontrib><creatorcontrib>Aktas, Akin</creatorcontrib><creatorcontrib>Erel, Ozcan</creatorcontrib><title>Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description><![CDATA[The aim of this study was to compare thiol/disulfide homeostasis and clinical parameters of rosacea patients across skin subtypes of the disease and healthy controls.
This prospective study included 90 rosacea patients with different skin subtypes (phymatous, erythematotelangiectatic and papulopustular) and ocular involvement and 30 healthy controls. Plasma native thiol (NT), total thiol (TT) and disulfide levels of the patients and controls were measured using an automated spectrophotometric method, and disulfide/native thiol ratio (DNTR), disulfide/total thiol ratio (DTTR) and native thiol/total thiol ratio (NTTR) were calculated. Tear breakup time (TBUT), meiboscore, Schirmer, ocular surface disease index (OSDI) and rosacea-specific quality of life scale (RosaQoL) were measured clinically.
Disulfide, DNTR and DTTR were significantly higher, and NT, TT and NTTR were significantly lower in the rosacea patients compared to the controls (
< 0.001). TBUT and Schirmer were significantly lower, and meiboscore and OSDI were significantly higher in the patients compared to the controls (
< 0.01). According to the skin subtypes, disulfide, DNTR and DTTR were significantly higher, and NTTR was significantly lower in the erythematotelangiectatic subtype compared to the other subtypes (
< 0.002). TBUT was significantly lower, and RosaQol was significantly higher in the erythematotelangiectatic subtype (
< 0.0083). Strong correlations were found between DNTR and TBUT and between DNTR and Meiboscore in all subtypes (
< 0.005), while there were strong correlations between DNTR and OSDI and between DNTR and RosaQol only in the erythematotelangiectatic and papulopustular subtypes (
< 0.05).
The thiol/disulfide homeostasis shifted towards disulfides, an indicator of oxidative stress in rosacea, and this was more pronounced in the erythematotelangiectatic subtype. The impairment in TBUT and RosaQol was also more prominent in the erythematotelangiectatic subtype and strongly associated with the DNTR.]]></description><subject>Automation</subject><subject>Chemical bonds</subject><subject>Disease</subject><subject>Gender</subject><subject>Homeostasis</subject><subject>Hydrogen</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Rosacea</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkctLBDEMxosoKron71LwIsi67bQz0x5lfYKg6N6Hvla7zrRr0xH87634QMwlIfzykeRD6ICSU8Ykma3MQBnlnNTVBtqtSNtOCRNs80-9gyYAK1JCCF7RdhvtlMmGE8l2EdyENwfZP6nsY8BxiRfPPvazcw9jv_TW4es4uAhZgQesgsXz3gdvVI_vVVKDyy4B9gE_RFDGqdLN3oUM-MyYmKwPTzhH_PhSkMdR5_e1g320tVQ9uMl33kOLy4vF_Hp6e3d1Mz-7nZqK1HlKJa-5tqyxrXMtYZpSrXVtueDU2ratNTENF45IqVTdiEoow2WjSWulsIrtoeMv2XWKr2M5shs8GNf3Krg4QseIqCmVhNUFPfqHruKYQlnuk-KyanhFCnXyRZkUAZJbduvkB5XeO0q6Tze6P24U-vBbc9SDs7_sz-_ZBzjghOw</recordid><startdate>20240711</startdate><enddate>20240711</enddate><creator>Yesilirmak, Nilufer</creator><creator>Saritas, Ozge</creator><creator>Kurt, Busra</creator><creator>Neselioglu, Salim</creator><creator>Aktas, Akin</creator><creator>Erel, Ozcan</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2996-3236</orcidid><orcidid>https://orcid.org/0000-0002-8632-2873</orcidid></search><sort><creationdate>20240711</creationdate><title>Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes</title><author>Yesilirmak, Nilufer ; Saritas, Ozge ; Kurt, Busra ; Neselioglu, Salim ; Aktas, Akin ; Erel, Ozcan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c205t-19454bd36d7ee703b11bbb5d4841dd775b0c648e099aa56828ac496b07d98da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Automation</topic><topic>Chemical bonds</topic><topic>Disease</topic><topic>Gender</topic><topic>Homeostasis</topic><topic>Hydrogen</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Rosacea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yesilirmak, Nilufer</creatorcontrib><creatorcontrib>Saritas, Ozge</creatorcontrib><creatorcontrib>Kurt, Busra</creatorcontrib><creatorcontrib>Neselioglu, Salim</creatorcontrib><creatorcontrib>Aktas, Akin</creatorcontrib><creatorcontrib>Erel, Ozcan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yesilirmak, Nilufer</au><au>Saritas, Ozge</au><au>Kurt, Busra</au><au>Neselioglu, Salim</au><au>Aktas, Akin</au><au>Erel, Ozcan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-07-11</date><risdate>2024</risdate><volume>13</volume><issue>14</issue><spage>4052</spage><pages>4052-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract><![CDATA[The aim of this study was to compare thiol/disulfide homeostasis and clinical parameters of rosacea patients across skin subtypes of the disease and healthy controls.
This prospective study included 90 rosacea patients with different skin subtypes (phymatous, erythematotelangiectatic and papulopustular) and ocular involvement and 30 healthy controls. Plasma native thiol (NT), total thiol (TT) and disulfide levels of the patients and controls were measured using an automated spectrophotometric method, and disulfide/native thiol ratio (DNTR), disulfide/total thiol ratio (DTTR) and native thiol/total thiol ratio (NTTR) were calculated. Tear breakup time (TBUT), meiboscore, Schirmer, ocular surface disease index (OSDI) and rosacea-specific quality of life scale (RosaQoL) were measured clinically.
Disulfide, DNTR and DTTR were significantly higher, and NT, TT and NTTR were significantly lower in the rosacea patients compared to the controls (
< 0.001). TBUT and Schirmer were significantly lower, and meiboscore and OSDI were significantly higher in the patients compared to the controls (
< 0.01). According to the skin subtypes, disulfide, DNTR and DTTR were significantly higher, and NTTR was significantly lower in the erythematotelangiectatic subtype compared to the other subtypes (
< 0.002). TBUT was significantly lower, and RosaQol was significantly higher in the erythematotelangiectatic subtype (
< 0.0083). Strong correlations were found between DNTR and TBUT and between DNTR and Meiboscore in all subtypes (
< 0.005), while there were strong correlations between DNTR and OSDI and between DNTR and RosaQol only in the erythematotelangiectatic and papulopustular subtypes (
< 0.05).
The thiol/disulfide homeostasis shifted towards disulfides, an indicator of oxidative stress in rosacea, and this was more pronounced in the erythematotelangiectatic subtype. The impairment in TBUT and RosaQol was also more prominent in the erythematotelangiectatic subtype and strongly associated with the DNTR.]]></abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39064093</pmid><doi>10.3390/jcm13144052</doi><orcidid>https://orcid.org/0000-0002-2996-3236</orcidid><orcidid>https://orcid.org/0000-0002-8632-2873</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Automation Chemical bonds Disease Gender Homeostasis Hydrogen Oxidative stress Pathogenesis Quality of life Questionnaires Rosacea |
| title | Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes |
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