Aurantiamide mitigates acute kidney injury by suppressing renal necroptosis and inflammation via GRPR-dependent mechanism

•GRPR is a newly discovered target for acute kidney injury.•Aurantiamide is a novel GRPR antagonist with high efficiency and safety in the treatment of AKI.•Aurantiamide protected kidney function and attenuated renal inflammation and necroptosis in two cell models and three mouse models.•We performe...

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Veröffentlicht in:	International immunopharmacology 2024-09, Vol.139, p.112745, Article 112745
Hauptverfasser:	He, Ruo-Bing, Li, Wei, Yao, Rui, Xu, Meng-Ying, Dong, Wei, Chen, Ying, Ni, Wei-Jian, Xie, Shuai-Shuai, Sun, Zheng-Hao, Li, Chao, Liu, Dong, Li, Shuang-Jian, Ji, Ming-Lu, Ru, Ya-Xin, Zhao, Tian, Zhu, Qi, Wen, Jia-Gen, Li, Jun, Jin, Juan, Yao, Ri-Sheng, Meng, Xiao-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney injury Aurantiamide GRPR Inflammation Necroptosis
Online-Zugang:	Volltext
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