Unlocking milk thistle’s anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress

[Display omitted] •Silychristin, silybin, and isosilybin were the silymarin components in MT extract.•MT extract topical application attenuated IMQ-induced psoriasis in mice.•Psoriasis was reduced by MT via PI3K/AKT/mTOR molecular cascade inhibition.•MT extract suppressed KEAP1/NF-κB and augmented N...

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Veröffentlicht in:	International immunopharmacology 2024-09, Vol.139, p.112781, Article 112781
Hauptverfasser:	Kamel, Nada M., El-Sayed, Sarah S., El-Said, Yasmin A.M., El-Kersh, Dina M., Hashem, Mona M., Mohamed, Sarah S.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Milk thistle mTOR NRF2 Psoriasis Silymarin
Online-Zugang:	Volltext
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