CD4+ T cell‐associated cytokines induce a chronic pro‐inflammatory phenotype in induced pluripotent stem cell‐derived midbrain astrocytes

Astrocytes are mediators of homeostasis but contribute to neuroinflammation in Parkinson's disease (PD). Mounting evidence suggests involvement of peripheral immune cells in PD pathogenesis. Therefore, this study aimed to determine the potential role of peripheral immune secreted cytokines in m...

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Veröffentlicht in:	Glia 2024-11, Vol.72 (11), p.2142-2154
Hauptverfasser:	MacMahon Copas, Adina N., McComish, Sarah F., Petrasca, Andreea, McCormack, Rachel, Ivers, Daniel, Stricker, Anna, Fletcher, Jean M., Caldwell, Maeve A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Astrocytes - drug effects Astrocytes - metabolism CD4 antigen CD4-Positive T-Lymphocytes - metabolism Cells, Cultured Chronic exposure Culture Media, Conditioned - pharmacology CXCL10 protein Cytokines Cytokines - metabolism Exposure Gene expression Helper cells Homeostasis Humans Immune system induced pluripotent stem cells Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Interleukin 6 Interleukin-17 - metabolism Interleukin-17 - pharmacology Lymphocytes Lymphocytes T Mesencephalon Mesencephalon - cytology Mesencephalon - metabolism Movement disorders Neurodegenerative diseases neuroinflammation NF-κB protein Parkinson's disease Pathogenesis Phenotype Phenotypes Pluripotency reactive astrocytes Reactivity Stem cells Synergistic effect Translocation Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
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