Iron scavenging and myeloid cell polarization

As a main source of erythrocyte degradation products, the process of hemolysis is a key determinant in skewing proinflammatory signatures in myeloid cells.Hemolytic products such as heme and iron can elicit proinflammatory effects, activating endothelial tissues and innate immunity.Iron plays an imp...

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Veröffentlicht in:	Trends in immunology 2024-08, Vol.45 (8), p.625-638
Hauptverfasser:	Ludwig, Natalie, Cucinelli, Stefania, Hametner, Simon, Muckenthaler, Martina U., Schirmer, Lucas
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Sickle Cell - immunology Anemia, Sickle Cell - metabolism Animals Cell Polarity hemolysis Homeostasis Humans Immunity, Innate Inflammation - immunology Inflammation - metabolism Iron - metabolism macrophages Mice multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Myeloid Cells - immunology Myeloid Cells - metabolism Neoplasms - immunology Neoplasms - metabolism neuroinflammation sickle cell disease tumor microenvironment
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