Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy

Although metabolic disturbance is a characteristic of diabetic cardiomyopathy (DbCM), the detailed pathogenesis of DbCM remains unknown. We used a heart transplantation (HTx) cohort to explore the effect of diabetes mellitus on heart failure (HF) progression dependent of myocardium. Microscopic and...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2024-09, Vol.158, p.155977, Article 155977
Hauptverfasser:	Shu, Songren, Cui, Hao, Liu, Zirui, Zhang, Hang, Yang, Yicheng, Chen, Xiao, Zeng, Zhiwei, Du, Leilei, Fu, Mengxia, Yang, Ziang, Wang, Peizhi, Wang, Chuangshi, Gao, Huimin, Yang, Qiaoxi, Lin, Xiaojun, Yang, Tianshuo, Chen, Zhice, Wu, Sijin, Wang, Xiaohu, Zhao, Ruojin, Hu, Shengshou, Song, Jiangping
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Animals Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Diabetic Cardiomyopathies - metabolism Diabetic Cardiomyopathies - pathology Diabetic cardiomyopathy Female Heart Failure - etiology Heart Failure - metabolism Heart Transplantation Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lipid accumulation Lipid Metabolism - physiology Male Mice Mice, Inbred C57BL Middle Aged Mitochondria fission Mitochondrial Dynamics - physiology Muscle Proteins - genetics Muscle Proteins - metabolism Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology RCAN1
Online-Zugang:	Volltext
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