Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)–Iridium(III) Imidazole–Phenanthroline Complexes with Aggregation-Induced Emission Properties
Organotin(IV) and iridium(III) complexes have shown good application potential in the field of anticancer; however, the aggregation-caused quenching (ACQ) effect induced by high concentration or dose has limited the research on their targeting and anticancer mechanism. Then, a series of aggregatio...
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| Veröffentlicht in: | Inorganic chemistry 2024-08, Vol.63 (31), p.14641-14655 |
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| container_title | Inorganic chemistry |
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| creator | Sun, Yiwei Liu, Jiayi Li, Qinyu Zhang, Xinru Cao, Ziwei Bu, Luoyi Cao, Shuying Liu, Xicheng Yuan, Xiang-Ai Liu, Zhe |
| description | Organotin(IV) and iridium(III) complexes have shown good application potential in the field of anticancer; however, the aggregation-caused quenching (ACQ) effect induced by high concentration or dose has limited the research on their targeting and anticancer mechanism. Then, a series of aggregation-induced emission (AIE)-activated butyltin(IV)–iridium(III) imidazole-phenanthroline complexes were prepared in this study. Complexes exhibited significant fluorescence improvement in the aggregated state because of the restricted intramolecular rotation (RIR), accompanied by an absolute fluorescence quantum yield of up to 29.2% (IrSn9). Complexes demonstrated potential in vitro antiproliferative and antimigration activity against A549 cells, following a lysosomal–mitochondrial apoptotic pathway. Nude mouse models further confirmed that complexes had favorable in vivo antitumor and antimigration activity in comparison to cisplatin. Therefore, butyltin(IV)–iridium(III) imidazole-phenanthroline complexes possess the potential as potential substitutes for platinum-based drugs. |
| doi_str_mv | 10.1021/acs.inorgchem.4c02160 |
| format | Article |
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Then, a series of aggregation-induced emission (AIE)-activated butyltin(IV)–iridium(III) imidazole-phenanthroline complexes were prepared in this study. Complexes exhibited significant fluorescence improvement in the aggregated state because of the restricted intramolecular rotation (RIR), accompanied by an absolute fluorescence quantum yield of up to 29.2% (IrSn9). Complexes demonstrated potential in vitro antiproliferative and antimigration activity against A549 cells, following a lysosomal–mitochondrial apoptotic pathway. Nude mouse models further confirmed that complexes had favorable in vivo antitumor and antimigration activity in comparison to cisplatin. Therefore, butyltin(IV)–iridium(III) imidazole-phenanthroline complexes possess the potential as potential substitutes for platinum-based drugs.</description><identifier>ISSN: 0020-1669</identifier><identifier>ISSN: 1520-510X</identifier><identifier>EISSN: 1520-510X</identifier><identifier>DOI: 10.1021/acs.inorgchem.4c02160</identifier><identifier>PMID: 39053139</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>A549 Cells ; Animals ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Cell Proliferation - drug effects ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Imidazoles - chemistry ; Imidazoles - pharmacology ; Iridium - chemistry ; Iridium - pharmacology ; Mice ; Mice, Nude ; Molecular Structure ; Organotin Compounds - chemical synthesis ; Organotin Compounds - chemistry ; Organotin Compounds - pharmacology ; Phenanthrolines - chemistry ; Phenanthrolines - pharmacology</subject><ispartof>Inorganic chemistry, 2024-08, Vol.63 (31), p.14641-14655</ispartof><rights>2024 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a229t-a26f20a0b610b06c9c9043f2552106153a6deb9d90c37fbfb21b1883dde0b1ee3</cites><orcidid>0000-0001-5796-4335 ; 0000-0002-7852-984X ; 0000-0002-5932-7206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.inorgchem.4c02160$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.inorgchem.4c02160$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39053139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Yiwei</creatorcontrib><creatorcontrib>Liu, Jiayi</creatorcontrib><creatorcontrib>Li, Qinyu</creatorcontrib><creatorcontrib>Zhang, Xinru</creatorcontrib><creatorcontrib>Cao, Ziwei</creatorcontrib><creatorcontrib>Bu, Luoyi</creatorcontrib><creatorcontrib>Cao, Shuying</creatorcontrib><creatorcontrib>Liu, Xicheng</creatorcontrib><creatorcontrib>Yuan, Xiang-Ai</creatorcontrib><creatorcontrib>Liu, Zhe</creatorcontrib><title>Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)–Iridium(III) Imidazole–Phenanthroline Complexes with Aggregation-Induced Emission Properties</title><title>Inorganic chemistry</title><addtitle>Inorg. Chem</addtitle><description>Organotin(IV) and iridium(III) complexes have shown good application potential in the field of anticancer; however, the aggregation-caused quenching (ACQ) effect induced by high concentration or dose has limited the research on their targeting and anticancer mechanism. Then, a series of aggregation-induced emission (AIE)-activated butyltin(IV)–iridium(III) imidazole-phenanthroline complexes were prepared in this study. Complexes exhibited significant fluorescence improvement in the aggregated state because of the restricted intramolecular rotation (RIR), accompanied by an absolute fluorescence quantum yield of up to 29.2% (IrSn9). Complexes demonstrated potential in vitro antiproliferative and antimigration activity against A549 cells, following a lysosomal–mitochondrial apoptotic pathway. Nude mouse models further confirmed that complexes had favorable in vivo antitumor and antimigration activity in comparison to cisplatin. Therefore, butyltin(IV)–iridium(III) imidazole-phenanthroline complexes possess the potential as potential substitutes for platinum-based drugs.</description><subject>A549 Cells</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Coordination Complexes - chemical synthesis</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination Complexes - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Humans</subject><subject>Imidazoles - chemistry</subject><subject>Imidazoles - pharmacology</subject><subject>Iridium - chemistry</subject><subject>Iridium - pharmacology</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Molecular Structure</subject><subject>Organotin Compounds - chemical synthesis</subject><subject>Organotin Compounds - chemistry</subject><subject>Organotin Compounds - pharmacology</subject><subject>Phenanthrolines - chemistry</subject><subject>Phenanthrolines - pharmacology</subject><issn>0020-1669</issn><issn>1520-510X</issn><issn>1520-510X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0EoqHwCCAv00XC9TjjxMsQFbBUiUpAxW7kse8krmbsYHsKZcU78BC8F0-Co4Ru2fjn3nOOr_UR8pLBnEHFXmuT5s6HuDU7HOYLU2oCHpEJqyuY1Qy-PCYTgHJmQsgz8iylWwCQfCGekjMuoeaMywn5_TGP1mGioaNrn53R3mCka5PdncuHhvL0xuUYqPb2eLkLtAuRvhnzfZ-dn6qbiz8_f6norBuHqVLqgqrBWf0j9Fga1zv02uddDL3zSDdh2Pf4vSR_c3lH19ttxK3OLviZ8nY0aOnl4FIqBXodwx7jYYzn5Emn-4QvTvs5-fz28tPm_ezqwzu1WV_NdFXJXFbRVaChFQxaEEYaCQveVXVdMRCs5lpYbKWVYPiya7u2Yi1brbi1CC1D5Odkeszdx_B1xJSbMovBvtcew5gaDqvFcslWbFmk9VFqYkgpYtfsoxt0vG8YNAdGTWHUPDBqToyK79XpibEd0D64_kEpAnYUHPy3YYy-_Pg_oX8BDSGmuw</recordid><startdate>20240805</startdate><enddate>20240805</enddate><creator>Sun, Yiwei</creator><creator>Liu, Jiayi</creator><creator>Li, Qinyu</creator><creator>Zhang, Xinru</creator><creator>Cao, Ziwei</creator><creator>Bu, Luoyi</creator><creator>Cao, Shuying</creator><creator>Liu, Xicheng</creator><creator>Yuan, Xiang-Ai</creator><creator>Liu, Zhe</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5796-4335</orcidid><orcidid>https://orcid.org/0000-0002-7852-984X</orcidid><orcidid>https://orcid.org/0000-0002-5932-7206</orcidid></search><sort><creationdate>20240805</creationdate><title>Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)–Iridium(III) Imidazole–Phenanthroline Complexes with Aggregation-Induced Emission Properties</title><author>Sun, Yiwei ; Liu, Jiayi ; Li, Qinyu ; Zhang, Xinru ; Cao, Ziwei ; Bu, Luoyi ; Cao, Shuying ; Liu, Xicheng ; Yuan, Xiang-Ai ; Liu, Zhe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a229t-a26f20a0b610b06c9c9043f2552106153a6deb9d90c37fbfb21b1883dde0b1ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>A549 Cells</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Coordination Complexes - chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination Complexes - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Humans</topic><topic>Imidazoles - chemistry</topic><topic>Imidazoles - pharmacology</topic><topic>Iridium - chemistry</topic><topic>Iridium - pharmacology</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Molecular Structure</topic><topic>Organotin Compounds - chemical synthesis</topic><topic>Organotin Compounds - chemistry</topic><topic>Organotin Compounds - pharmacology</topic><topic>Phenanthrolines - chemistry</topic><topic>Phenanthrolines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yiwei</creatorcontrib><creatorcontrib>Liu, Jiayi</creatorcontrib><creatorcontrib>Li, Qinyu</creatorcontrib><creatorcontrib>Zhang, Xinru</creatorcontrib><creatorcontrib>Cao, Ziwei</creatorcontrib><creatorcontrib>Bu, Luoyi</creatorcontrib><creatorcontrib>Cao, Shuying</creatorcontrib><creatorcontrib>Liu, Xicheng</creatorcontrib><creatorcontrib>Yuan, Xiang-Ai</creatorcontrib><creatorcontrib>Liu, Zhe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yiwei</au><au>Liu, Jiayi</au><au>Li, Qinyu</au><au>Zhang, Xinru</au><au>Cao, Ziwei</au><au>Bu, Luoyi</au><au>Cao, Shuying</au><au>Liu, Xicheng</au><au>Yuan, Xiang-Ai</au><au>Liu, Zhe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)–Iridium(III) Imidazole–Phenanthroline Complexes with Aggregation-Induced Emission Properties</atitle><jtitle>Inorganic chemistry</jtitle><addtitle>Inorg. Chem</addtitle><date>2024-08-05</date><risdate>2024</risdate><volume>63</volume><issue>31</issue><spage>14641</spage><epage>14655</epage><pages>14641-14655</pages><issn>0020-1669</issn><issn>1520-510X</issn><eissn>1520-510X</eissn><abstract>Organotin(IV) and iridium(III) complexes have shown good application potential in the field of anticancer; however, the aggregation-caused quenching (ACQ) effect induced by high concentration or dose has limited the research on their targeting and anticancer mechanism. Then, a series of aggregation-induced emission (AIE)-activated butyltin(IV)–iridium(III) imidazole-phenanthroline complexes were prepared in this study. Complexes exhibited significant fluorescence improvement in the aggregated state because of the restricted intramolecular rotation (RIR), accompanied by an absolute fluorescence quantum yield of up to 29.2% (IrSn9). Complexes demonstrated potential in vitro antiproliferative and antimigration activity against A549 cells, following a lysosomal–mitochondrial apoptotic pathway. Nude mouse models further confirmed that complexes had favorable in vivo antitumor and antimigration activity in comparison to cisplatin. Therefore, butyltin(IV)–iridium(III) imidazole-phenanthroline complexes possess the potential as potential substitutes for platinum-based drugs.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>39053139</pmid><doi>10.1021/acs.inorgchem.4c02160</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5796-4335</orcidid><orcidid>https://orcid.org/0000-0002-7852-984X</orcidid><orcidid>https://orcid.org/0000-0002-5932-7206</orcidid></addata></record> |
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| subjects | A549 Cells Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Proliferation - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Drug Screening Assays, Antitumor Humans Imidazoles - chemistry Imidazoles - pharmacology Iridium - chemistry Iridium - pharmacology Mice Mice, Nude Molecular Structure Organotin Compounds - chemical synthesis Organotin Compounds - chemistry Organotin Compounds - pharmacology Phenanthrolines - chemistry Phenanthrolines - pharmacology |
| title | Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)–Iridium(III) Imidazole–Phenanthroline Complexes with Aggregation-Induced Emission Properties |
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