Hemagglutination Inhibition Antibody Titers as Mediators of Influenza Vaccine Efficacy Against Symptomatic Influenza A(H1N1), A(H3N2), and B/Victoria Virus Infections

The hemagglutination inhibition antibody (HAI) titer contributes only a part of vaccine-induced protection against influenza virus infections. Using causal mediation analysis, we quantified the proportion of vaccine efficacy mediated by postvaccination HAI titers. We conducted causal mediation analy...

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Veröffentlicht in:	The Journal of infectious diseases 2024-07, Vol.230 (1), p.152-160
Hauptverfasser:	Lim, Wey Wen, Feng, Shuo, Wong, Sook-San, Sullivan, Sheena G, Cowling, Benjamin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - blood Antibodies, Viral - immunology Child Child, Preschool Female Hemagglutination Inhibition Tests Humans Infant Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Influenza B virus - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Male Vaccine Efficacy Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology
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