Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells
Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated t...
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| Veröffentlicht in: | The Journal of infectious diseases 2024-07, Vol.230 (1), p.e43-e47 |
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| container_title | The Journal of infectious diseases |
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| creator | van Teijlingen, Nienke H van Smoorenburg, Marleen Y Sarrami-Forooshani, Ramin Zijlstra-Willems, Esther M van Hamme, John L Borgdorff, Hanneke van de Wijgert, Janneke H H M van Leeuwen, Elisabeth van der Post, Joris A M Strijbis, Karin Ribeiro, Carla M S Geijtenbeek, Teunis B H |
| description | Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis-enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment. |
| doi_str_mv | 10.1093/infdis/jiae166 |
| format | Article |
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Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis-enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment.</description><identifier>ISSN: 0022-1899</identifier><identifier>ISSN: 1537-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiae166</identifier><identifier>PMID: 39052703</identifier><language>eng</language><publisher>United States</publisher><subject>CD4-Positive T-Lymphocytes - immunology ; Disease Susceptibility ; Dysbiosis - microbiology ; Female ; HIV Infections - immunology ; HIV Infections - microbiology ; HIV Infections - virology ; HIV-1 ; Humans ; Microbiota ; Prevotella - isolation & purification ; Vagina - immunology ; Vagina - microbiology ; Vagina - virology ; Virus Internalization</subject><ispartof>The Journal of infectious diseases, 2024-07, Vol.230 (1), p.e43-e47</ispartof><rights>The Author(s) 2024. 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Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis-enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment.</description><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Disease Susceptibility</subject><subject>Dysbiosis - microbiology</subject><subject>Female</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - microbiology</subject><subject>HIV Infections - virology</subject><subject>HIV-1</subject><subject>Humans</subject><subject>Microbiota</subject><subject>Prevotella - isolation & purification</subject><subject>Vagina - immunology</subject><subject>Vagina - microbiology</subject><subject>Vagina - virology</subject><subject>Virus Internalization</subject><issn>0022-1899</issn><issn>1537-6613</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctKxDAUhoMoOl62LiVLQeokTSdpljpeYUDBUZclTU_0SJuOTSr0OXxhKzO6Opvv_PwXQo45O-dMiyl6V2GYfqABLuUWmfCZUImUXGyTCWNpmvBc6z2yH8IHYywTUu2SPaHZLFVMTMj3YwdfbYS6NjRi03rwAQO9NDZCh4ZehNBaNBEq-orxnb6YN_SmpldDKLH9Ra_9u_EW6F3fGE_vm6b3bQUOLYK3A33Brg90OayAcvrUBwuriCXWGAf64P715lfZGV3S-WgkHJIdZ-oAR5t7QJ5vrpfzu2TxcHs_v1gkNk1ZTKStIM-Nc6mWYyArJGinUi6dcpZllRRlKYyzVS7LPFUy005oC6WCkudgjDggp2vdVdd-9hBi0eDob6zCQ9uHQrA8U4oLPRvR8zVquzaEDlyx6rAx3VBwVvwOUayHKDZDjA8nG-2-bKD6x_-aFz8ii4kv</recordid><startdate>20240725</startdate><enddate>20240725</enddate><creator>van Teijlingen, Nienke H</creator><creator>van Smoorenburg, Marleen Y</creator><creator>Sarrami-Forooshani, Ramin</creator><creator>Zijlstra-Willems, Esther M</creator><creator>van Hamme, John L</creator><creator>Borgdorff, Hanneke</creator><creator>van de Wijgert, Janneke H H M</creator><creator>van Leeuwen, Elisabeth</creator><creator>van der Post, Joris A M</creator><creator>Strijbis, Karin</creator><creator>Ribeiro, Carla M S</creator><creator>Geijtenbeek, Teunis B H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5710-2839</orcidid><orcidid>https://orcid.org/0000-0003-2728-4560</orcidid><orcidid>https://orcid.org/0000-0003-2413-0136</orcidid><orcidid>https://orcid.org/0000-0003-3311-2116</orcidid><orcidid>https://orcid.org/0000-0002-6999-9145</orcidid><orcidid>https://orcid.org/0000-0001-9167-7137</orcidid><orcidid>https://orcid.org/0000-0003-0765-9441</orcidid><orcidid>https://orcid.org/0000-0003-2463-9127</orcidid><orcidid>https://orcid.org/0000-0003-4277-9377</orcidid><orcidid>https://orcid.org/0000-0002-5693-1619</orcidid><orcidid>https://orcid.org/0000-0002-5682-4143</orcidid></search><sort><creationdate>20240725</creationdate><title>Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells</title><author>van Teijlingen, Nienke H ; 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| ispartof | The Journal of infectious diseases, 2024-07, Vol.230 (1), p.e43-e47 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | CD4-Positive T-Lymphocytes - immunology Disease Susceptibility Dysbiosis - microbiology Female HIV Infections - immunology HIV Infections - microbiology HIV Infections - virology HIV-1 Humans Microbiota Prevotella - isolation & purification Vagina - immunology Vagina - microbiology Vagina - virology Virus Internalization |
| title | Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells |
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