Computational identification of potential tau tubulin kinase 1 (TTBK1) inhibitors: a structural analog approach

Abnormal deposition or aggregation of protein alpha-synuclein and tau in the brain leads to neurodegenerative disorders. Excessive hyperphosphorylation of tau protein and aggregations destroys the microtubule structure resulting in neurofibrillary tangles in neurons and affecting cytoskeleton struct...

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