Efficient Synthesis of a C2‐Symmetric 2,2′‐Bipyridine‐α,α′‐1‐t–butyl‐diol Ligand by Stereoselective Double Hydrogen Transfer to a 2,2′‐Bipyridine‐diketone

An efficient and practical method was developed for the synthesis of C2‐symmetric 2,2′‐bipyridine‐α,α′‐1‐t‐butyl‐diol ligands. The disclosed synthesis involves the Ullmann homocoupling of a keto bromo‐pyridine under NiCl2/Zn/PPh3 conditions, followed by the stereoselective double hydrogen transfer t...

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Veröffentlicht in:	Chemistry : a European journal 2024-10, Vol.30 (56), p.e202402449-n/a
Hauptverfasser:	Bouzid, Stéphany, Marcoux, Antony, Ollevier, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric catalysis Catalysts Chemical synthesis Chiral ligand Diketones Enantioselectivity Hydrogen Hydrogen transfer Ligands Nickel chloride Noyori-Ikariya catalyst Stereoselective reduction Stereoselectivity
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