The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner
The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long-term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2024-07, Vol.121 (31), p.e2407472121 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 31 |
| container_start_page | e2407472121 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 121 |
| creator | Mahmood, Niaz Choi, Jung-Hyun Wu, Pei You Dooling, Sean W Watkins, Trent A Huang, Ziying Lipman, Jesse Zhao, Hanjie Yang, Anqi Silversmith, Jake Inglebert, Yanis Koumenis, Constantinos Sharma, Vijendra Lacaille, Jean-Claude Sossin, Wayne S Khoutorsky, Arkady McKinney, R Anne Costa-Mattioli, Mauro Sonenberg, Nahum |
| description | The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long-term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), a key downstream effector of the ISR, in various neuronal and non-neuronal cell types. We found that the removal of ATF4 from forebrain excitatory neurons (but not from inhibitory neurons, cholinergic neurons, or astrocytes) enhances LTM formation. Furthermore, the deletion of ATF4 in excitatory neurons lowers the threshold for the induction of long-term potentiation, a cellular model for LTM. Transcriptomic and proteomic analyses revealed that ATF4 deletion in excitatory neurons leads to upregulation of components of oxidative phosphorylation pathways, which are critical for ATP production. Thus, we conclude that ATF4 functions as a memory repressor selectively within excitatory neurons. |
| doi_str_mv | 10.1073/pnas.2407472121 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_3084766172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3087390175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1804-bbe9ed2bd3878d42265fb7d57df6a333dbd38931b1f343ed9fdd3098c4ced6dd3</originalsourceid><addsrcrecordid>eNpdkc1P3DAQxa2qCJYt594qS730Ehh_JI5PFUIFVkJCgkXqzXLiyRKU2Kmdpdr_vomAbctpRprfPM2bR8hnBqcMlDgbvE2nXIKSijPOPpAFA82yQmr4SBYAXGWl5PKIHKf0BAA6L-GQHAkNUoEoF-Tn-hHp6v6OuvDbpzGi7elo4wZHer6-lDTiEDElTLQLfpONGHvaYx_ijraeWlpj19FxN2CWBqzbpq1pb73H-IkcNLZLePJal-Th8sf64jq7ub1aXZzfZDUrQWZVhRodr5woVekk50XeVMrlyjWFFUK4eaIFq1gjpECnG-cE6LKWNbpi6pfk-4vusK16dDX6MdrODLHtbdyZYFvz_8S3j2YTng1jXOcwiS7Jt1eFGH5tMY2mb9Psy3oM22QElFIVBVN8Qr--Q5_CNvrJ30yp6a1M5RN19kLVMaQUsdlfw8DMsZk5NvM3tmnjy78m9vxbTuIPlB2UiQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3087390175</pqid></control><display><type>article</type><title>The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Mahmood, Niaz ; Choi, Jung-Hyun ; Wu, Pei You ; Dooling, Sean W ; Watkins, Trent A ; Huang, Ziying ; Lipman, Jesse ; Zhao, Hanjie ; Yang, Anqi ; Silversmith, Jake ; Inglebert, Yanis ; Koumenis, Constantinos ; Sharma, Vijendra ; Lacaille, Jean-Claude ; Sossin, Wayne S ; Khoutorsky, Arkady ; McKinney, R Anne ; Costa-Mattioli, Mauro ; Sonenberg, Nahum</creator><creatorcontrib>Mahmood, Niaz ; Choi, Jung-Hyun ; Wu, Pei You ; Dooling, Sean W ; Watkins, Trent A ; Huang, Ziying ; Lipman, Jesse ; Zhao, Hanjie ; Yang, Anqi ; Silversmith, Jake ; Inglebert, Yanis ; Koumenis, Constantinos ; Sharma, Vijendra ; Lacaille, Jean-Claude ; Sossin, Wayne S ; Khoutorsky, Arkady ; McKinney, R Anne ; Costa-Mattioli, Mauro ; Sonenberg, Nahum</creatorcontrib><description>The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long-term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), a key downstream effector of the ISR, in various neuronal and non-neuronal cell types. We found that the removal of ATF4 from forebrain excitatory neurons (but not from inhibitory neurons, cholinergic neurons, or astrocytes) enhances LTM formation. Furthermore, the deletion of ATF4 in excitatory neurons lowers the threshold for the induction of long-term potentiation, a cellular model for LTM. Transcriptomic and proteomic analyses revealed that ATF4 deletion in excitatory neurons leads to upregulation of components of oxidative phosphorylation pathways, which are critical for ATP production. Thus, we conclude that ATF4 functions as a memory repressor selectively within excitatory neurons.</description><identifier>ISSN: 0027-8424</identifier><identifier>ISSN: 1091-6490</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.2407472121</identifier><identifier>PMID: 39047038</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Activating transcription factor 4 ; Activating Transcription Factor 4 - genetics ; Activating Transcription Factor 4 - metabolism ; Animals ; Astrocytes ; Astrocytes - metabolism ; Biological Sciences ; Cellular stress response ; Cholinergics ; Clonal deletion ; Deletion ; Forebrain ; Gene deletion ; Homeostasis ; Long term memory ; Long-Term Potentiation ; Male ; Memory ; Memory, Long-Term - physiology ; Mice ; Mice, Knockout ; Neurons ; Neurons - metabolism ; Oxidative phosphorylation ; Phosphorylation ; Prosencephalon - metabolism ; Proteomics ; Transcriptomics</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2024-07, Vol.121 (31), p.e2407472121</ispartof><rights>Copyright National Academy of Sciences Jul 30, 2024</rights><rights>Copyright © 2024 the Author(s). Published by PNAS. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1804-bbe9ed2bd3878d42265fb7d57df6a333dbd38931b1f343ed9fdd3098c4ced6dd3</cites><orcidid>0000-0002-6828-6901 ; 0000-0003-1927-9315 ; 0000-0003-4056-0574 ; 0000-0002-8992-4992 ; 0000-0002-4707-8759 ; 0000-0002-9732-4663 ; 0000-0001-6723-3712</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295034/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295034/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39047038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmood, Niaz</creatorcontrib><creatorcontrib>Choi, Jung-Hyun</creatorcontrib><creatorcontrib>Wu, Pei You</creatorcontrib><creatorcontrib>Dooling, Sean W</creatorcontrib><creatorcontrib>Watkins, Trent A</creatorcontrib><creatorcontrib>Huang, Ziying</creatorcontrib><creatorcontrib>Lipman, Jesse</creatorcontrib><creatorcontrib>Zhao, Hanjie</creatorcontrib><creatorcontrib>Yang, Anqi</creatorcontrib><creatorcontrib>Silversmith, Jake</creatorcontrib><creatorcontrib>Inglebert, Yanis</creatorcontrib><creatorcontrib>Koumenis, Constantinos</creatorcontrib><creatorcontrib>Sharma, Vijendra</creatorcontrib><creatorcontrib>Lacaille, Jean-Claude</creatorcontrib><creatorcontrib>Sossin, Wayne S</creatorcontrib><creatorcontrib>Khoutorsky, Arkady</creatorcontrib><creatorcontrib>McKinney, R Anne</creatorcontrib><creatorcontrib>Costa-Mattioli, Mauro</creatorcontrib><creatorcontrib>Sonenberg, Nahum</creatorcontrib><title>The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long-term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), a key downstream effector of the ISR, in various neuronal and non-neuronal cell types. We found that the removal of ATF4 from forebrain excitatory neurons (but not from inhibitory neurons, cholinergic neurons, or astrocytes) enhances LTM formation. Furthermore, the deletion of ATF4 in excitatory neurons lowers the threshold for the induction of long-term potentiation, a cellular model for LTM. Transcriptomic and proteomic analyses revealed that ATF4 deletion in excitatory neurons leads to upregulation of components of oxidative phosphorylation pathways, which are critical for ATP production. Thus, we conclude that ATF4 functions as a memory repressor selectively within excitatory neurons.</description><subject>Activating transcription factor 4</subject><subject>Activating Transcription Factor 4 - genetics</subject><subject>Activating Transcription Factor 4 - metabolism</subject><subject>Animals</subject><subject>Astrocytes</subject><subject>Astrocytes - metabolism</subject><subject>Biological Sciences</subject><subject>Cellular stress response</subject><subject>Cholinergics</subject><subject>Clonal deletion</subject><subject>Deletion</subject><subject>Forebrain</subject><subject>Gene deletion</subject><subject>Homeostasis</subject><subject>Long term memory</subject><subject>Long-Term Potentiation</subject><subject>Male</subject><subject>Memory</subject><subject>Memory, Long-Term - physiology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Oxidative phosphorylation</subject><subject>Phosphorylation</subject><subject>Prosencephalon - metabolism</subject><subject>Proteomics</subject><subject>Transcriptomics</subject><issn>0027-8424</issn><issn>1091-6490</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1P3DAQxa2qCJYt594qS730Ehh_JI5PFUIFVkJCgkXqzXLiyRKU2Kmdpdr_vomAbctpRprfPM2bR8hnBqcMlDgbvE2nXIKSijPOPpAFA82yQmr4SBYAXGWl5PKIHKf0BAA6L-GQHAkNUoEoF-Tn-hHp6v6OuvDbpzGi7elo4wZHer6-lDTiEDElTLQLfpONGHvaYx_ijraeWlpj19FxN2CWBqzbpq1pb73H-IkcNLZLePJal-Th8sf64jq7ub1aXZzfZDUrQWZVhRodr5woVekk50XeVMrlyjWFFUK4eaIFq1gjpECnG-cE6LKWNbpi6pfk-4vusK16dDX6MdrODLHtbdyZYFvz_8S3j2YTng1jXOcwiS7Jt1eFGH5tMY2mb9Psy3oM22QElFIVBVN8Qr--Q5_CNvrJ30yp6a1M5RN19kLVMaQUsdlfw8DMsZk5NvM3tmnjy78m9vxbTuIPlB2UiQ</recordid><startdate>20240730</startdate><enddate>20240730</enddate><creator>Mahmood, Niaz</creator><creator>Choi, Jung-Hyun</creator><creator>Wu, Pei You</creator><creator>Dooling, Sean W</creator><creator>Watkins, Trent A</creator><creator>Huang, Ziying</creator><creator>Lipman, Jesse</creator><creator>Zhao, Hanjie</creator><creator>Yang, Anqi</creator><creator>Silversmith, Jake</creator><creator>Inglebert, Yanis</creator><creator>Koumenis, Constantinos</creator><creator>Sharma, Vijendra</creator><creator>Lacaille, Jean-Claude</creator><creator>Sossin, Wayne S</creator><creator>Khoutorsky, Arkady</creator><creator>McKinney, R Anne</creator><creator>Costa-Mattioli, Mauro</creator><creator>Sonenberg, Nahum</creator><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6828-6901</orcidid><orcidid>https://orcid.org/0000-0003-1927-9315</orcidid><orcidid>https://orcid.org/0000-0003-4056-0574</orcidid><orcidid>https://orcid.org/0000-0002-8992-4992</orcidid><orcidid>https://orcid.org/0000-0002-4707-8759</orcidid><orcidid>https://orcid.org/0000-0002-9732-4663</orcidid><orcidid>https://orcid.org/0000-0001-6723-3712</orcidid></search><sort><creationdate>20240730</creationdate><title>The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner</title><author>Mahmood, Niaz ; Choi, Jung-Hyun ; Wu, Pei You ; Dooling, Sean W ; Watkins, Trent A ; Huang, Ziying ; Lipman, Jesse ; Zhao, Hanjie ; Yang, Anqi ; Silversmith, Jake ; Inglebert, Yanis ; Koumenis, Constantinos ; Sharma, Vijendra ; Lacaille, Jean-Claude ; Sossin, Wayne S ; Khoutorsky, Arkady ; McKinney, R Anne ; Costa-Mattioli, Mauro ; Sonenberg, Nahum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1804-bbe9ed2bd3878d42265fb7d57df6a333dbd38931b1f343ed9fdd3098c4ced6dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Activating transcription factor 4</topic><topic>Activating Transcription Factor 4 - genetics</topic><topic>Activating Transcription Factor 4 - metabolism</topic><topic>Animals</topic><topic>Astrocytes</topic><topic>Astrocytes - metabolism</topic><topic>Biological Sciences</topic><topic>Cellular stress response</topic><topic>Cholinergics</topic><topic>Clonal deletion</topic><topic>Deletion</topic><topic>Forebrain</topic><topic>Gene deletion</topic><topic>Homeostasis</topic><topic>Long term memory</topic><topic>Long-Term Potentiation</topic><topic>Male</topic><topic>Memory</topic><topic>Memory, Long-Term - physiology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Oxidative phosphorylation</topic><topic>Phosphorylation</topic><topic>Prosencephalon - metabolism</topic><topic>Proteomics</topic><topic>Transcriptomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahmood, Niaz</creatorcontrib><creatorcontrib>Choi, Jung-Hyun</creatorcontrib><creatorcontrib>Wu, Pei You</creatorcontrib><creatorcontrib>Dooling, Sean W</creatorcontrib><creatorcontrib>Watkins, Trent A</creatorcontrib><creatorcontrib>Huang, Ziying</creatorcontrib><creatorcontrib>Lipman, Jesse</creatorcontrib><creatorcontrib>Zhao, Hanjie</creatorcontrib><creatorcontrib>Yang, Anqi</creatorcontrib><creatorcontrib>Silversmith, Jake</creatorcontrib><creatorcontrib>Inglebert, Yanis</creatorcontrib><creatorcontrib>Koumenis, Constantinos</creatorcontrib><creatorcontrib>Sharma, Vijendra</creatorcontrib><creatorcontrib>Lacaille, Jean-Claude</creatorcontrib><creatorcontrib>Sossin, Wayne S</creatorcontrib><creatorcontrib>Khoutorsky, Arkady</creatorcontrib><creatorcontrib>McKinney, R Anne</creatorcontrib><creatorcontrib>Costa-Mattioli, Mauro</creatorcontrib><creatorcontrib>Sonenberg, Nahum</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmood, Niaz</au><au>Choi, Jung-Hyun</au><au>Wu, Pei You</au><au>Dooling, Sean W</au><au>Watkins, Trent A</au><au>Huang, Ziying</au><au>Lipman, Jesse</au><au>Zhao, Hanjie</au><au>Yang, Anqi</au><au>Silversmith, Jake</au><au>Inglebert, Yanis</au><au>Koumenis, Constantinos</au><au>Sharma, Vijendra</au><au>Lacaille, Jean-Claude</au><au>Sossin, Wayne S</au><au>Khoutorsky, Arkady</au><au>McKinney, R Anne</au><au>Costa-Mattioli, Mauro</au><au>Sonenberg, Nahum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2024-07-30</date><risdate>2024</risdate><volume>121</volume><issue>31</issue><spage>e2407472121</spage><pages>e2407472121-</pages><issn>0027-8424</issn><issn>1091-6490</issn><eissn>1091-6490</eissn><abstract>The integrated stress response (ISR), a pivotal protein homeostasis network, plays a critical role in the formation of long-term memory (LTM). The precise mechanism by which the ISR controls LTM is not well understood. Here, we report insights into how the ISR modulates the mnemonic process by using targeted deletion of the activating transcription factor 4 (ATF4), a key downstream effector of the ISR, in various neuronal and non-neuronal cell types. We found that the removal of ATF4 from forebrain excitatory neurons (but not from inhibitory neurons, cholinergic neurons, or astrocytes) enhances LTM formation. Furthermore, the deletion of ATF4 in excitatory neurons lowers the threshold for the induction of long-term potentiation, a cellular model for LTM. Transcriptomic and proteomic analyses revealed that ATF4 deletion in excitatory neurons leads to upregulation of components of oxidative phosphorylation pathways, which are critical for ATP production. Thus, we conclude that ATF4 functions as a memory repressor selectively within excitatory neurons.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>39047038</pmid><doi>10.1073/pnas.2407472121</doi><orcidid>https://orcid.org/0000-0002-6828-6901</orcidid><orcidid>https://orcid.org/0000-0003-1927-9315</orcidid><orcidid>https://orcid.org/0000-0003-4056-0574</orcidid><orcidid>https://orcid.org/0000-0002-8992-4992</orcidid><orcidid>https://orcid.org/0000-0002-4707-8759</orcidid><orcidid>https://orcid.org/0000-0002-9732-4663</orcidid><orcidid>https://orcid.org/0000-0001-6723-3712</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2024-07, Vol.121 (31), p.e2407472121 |
| issn | 0027-8424 1091-6490 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3084766172 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Activating transcription factor 4 Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Animals Astrocytes Astrocytes - metabolism Biological Sciences Cellular stress response Cholinergics Clonal deletion Deletion Forebrain Gene deletion Homeostasis Long term memory Long-Term Potentiation Male Memory Memory, Long-Term - physiology Mice Mice, Knockout Neurons Neurons - metabolism Oxidative phosphorylation Phosphorylation Prosencephalon - metabolism Proteomics Transcriptomics |
| title | The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T11%3A05%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20ISR%20downstream%20target%20ATF4%20represses%20long-term%20memory%20in%20a%20cell%20type-specific%20manner&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Mahmood,%20Niaz&rft.date=2024-07-30&rft.volume=121&rft.issue=31&rft.spage=e2407472121&rft.pages=e2407472121-&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.2407472121&rft_dat=%3Cproquest_pubme%3E3087390175%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3087390175&rft_id=info:pmid/39047038&rfr_iscdi=true |