Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults
The addition of blinatumomab to consolidation chemotherapy in adults with B-cell precursor acute lymphoblastic leukemia who had minimal residual disease–negative status after treatment improved overall and relapse-free survival.
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| Veröffentlicht in: | The New England journal of medicine 2024-07, Vol.391 (4), p.320-333 |
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| container_title | The New England journal of medicine |
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| creator | Litzow, Mark R. Sun, Zhuoxin Mattison, Ryan J. Paietta, Elisabeth M. Roberts, Kathryn G. Zhang, Yanming Racevskis, Janis Lazarus, Hillard M. Rowe, Jacob M. Arber, Daniel A. Wieduwilt, Matthew J. Liedtke, Michaela Bergeron, Julie Wood, Brent L. Zhao, Yaqi Wu, Gang Chang, Ti-Cheng Zhang, Wenchao Pratz, Keith W. Dinner, Shira N. Frey, Noelle Gore, Steven D. Bhatnagar, Bhavana Atallah, Ehab L. Uy, Geoffrey L. Jeyakumar, Deepa Lin, Tara L. Willman, Cheryl L. DeAngelo, Daniel J. Patel, Shejal B. Elliott, Michelle A. Advani, Anjali S. Tzachanis, Dimitrios Vachhani, Pankit Bhave, Rupali R. Sharon, Elad Little, Richard F. Erba, Harry P. Stone, Richard M. Luger, Selina M. Mullighan, Charles G. Tallman, Martin S. |
| description | The addition of blinatumomab to consolidation chemotherapy in adults with B-cell precursor acute lymphoblastic leukemia who had minimal residual disease–negative status after treatment improved overall and relapse-free survival. |
| doi_str_mv | 10.1056/NEJMoa2312948 |
| format | Article |
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S.</creatorcontrib><title>Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>The addition of blinatumomab to consolidation chemotherapy in adults with B-cell precursor acute lymphoblastic leukemia who had minimal residual disease–negative status after treatment improved overall and relapse-free survival.</description><subject>Acute lymphoblastic leukemia</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Antibodies, Bispecific - administration & dosage</subject><subject>Antibodies, Bispecific - adverse effects</subject><subject>Antibodies, Bispecific - therapeutic use</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bone marrow</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Consolidation Chemotherapy</subject><subject>Data collection</subject><subject>Disease-Free Survival</subject><subject>FDA approval</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Hematology</subject><subject>Humans</subject><subject>Induction Chemotherapy</subject><subject>Induction therapy</subject><subject>Kaplan-Meier Estimate</subject><subject>Leukemia</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Neoplasm, Residual</subject><subject>Oncology</subject><subject>Pediatrics</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology</subject><subject>Recurrence</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Remission Induction</subject><subject>Survival Analysis</subject><subject>Targeted cancer therapy</subject><subject>Transplants & implants</subject><subject>Treatments in Oncology</subject><subject>Young 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titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Litzow, Mark R.</au><au>Sun, Zhuoxin</au><au>Mattison, Ryan J.</au><au>Paietta, Elisabeth M.</au><au>Roberts, Kathryn G.</au><au>Zhang, Yanming</au><au>Racevskis, Janis</au><au>Lazarus, Hillard M.</au><au>Rowe, Jacob M.</au><au>Arber, Daniel A.</au><au>Wieduwilt, Matthew J.</au><au>Liedtke, Michaela</au><au>Bergeron, Julie</au><au>Wood, Brent L.</au><au>Zhao, Yaqi</au><au>Wu, Gang</au><au>Chang, Ti-Cheng</au><au>Zhang, Wenchao</au><au>Pratz, Keith W.</au><au>Dinner, Shira N.</au><au>Frey, Noelle</au><au>Gore, Steven D.</au><au>Bhatnagar, Bhavana</au><au>Atallah, Ehab L.</au><au>Uy, Geoffrey L.</au><au>Jeyakumar, Deepa</au><au>Lin, Tara L.</au><au>Willman, Cheryl L.</au><au>DeAngelo, Daniel J.</au><au>Patel, Shejal B.</au><au>Elliott, Michelle A.</au><au>Advani, Anjali S.</au><au>Tzachanis, Dimitrios</au><au>Vachhani, Pankit</au><au>Bhave, Rupali R.</au><au>Sharon, Elad</au><au>Little, Richard F.</au><au>Erba, Harry P.</au><au>Stone, Richard M.</au><au>Luger, Selina M.</au><au>Mullighan, Charles G.</au><au>Tallman, Martin S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2024-07-25</date><risdate>2024</risdate><volume>391</volume><issue>4</issue><spage>320</spage><epage>333</epage><pages>320-333</pages><issn>0028-4793</issn><issn>1533-4406</issn><eissn>1533-4406</eissn><abstract>The addition of blinatumomab to consolidation chemotherapy in adults with B-cell precursor acute lymphoblastic leukemia who had minimal residual disease–negative status after treatment improved overall and relapse-free survival.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>39047240</pmid><doi>10.1056/NEJMoa2312948</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1871-1850</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2024-07, Vol.391 (4), p.320-333 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3084766131 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Acute lymphoblastic leukemia Adult Age Aged Antibodies, Bispecific - administration & dosage Antibodies, Bispecific - adverse effects Antibodies, Bispecific - therapeutic use Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bone marrow Cancer therapies Chemotherapy Clinical trials Consolidation Chemotherapy Data collection Disease-Free Survival FDA approval Female Flow cytometry Hematology Humans Induction Chemotherapy Induction therapy Kaplan-Meier Estimate Leukemia Lymphatic leukemia Lymphocytes B Lymphocytes T Lymphoma Male Medical prognosis Middle Aged Monoclonal antibodies Neoplasm, Residual Oncology Pediatrics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Recurrence Remission Remission (Medicine) Remission Induction Survival Analysis Targeted cancer therapy Transplants & implants Treatments in Oncology Young adults |
| title | Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults |
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