Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition

Ferroptosis, a distinctive form of programmed cell death, has been implicated in numerous pathological conditions, and its inhibition is considered a promising therapeutic strategy. Currently, there is a scarcity of efficient antagonists for directly regulating intracellular ferrous iron. Ferritinop...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-08, Vol.67 (15), p.12521-12533
Hauptverfasser:	Ji, Jian’ai, Jin, Yuhui, Ma, Sinan, Zhu, Yuxuan, Bi, Xinyu, You, Qidong, Jiang, Zhengyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Discovery Ferroptosis - drug effects Humans Iron - metabolism Male Mice Mice, Inbred C57BL Nuclear Receptor Coactivators - antagonists & inhibitors Nuclear Receptor Coactivators - metabolism Peptides - chemistry Peptides - drug effects Peptides - metabolism
Online-Zugang:	Volltext
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