A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults
Background Non-steroidal anti-inflammatory drugs (NSAIDs) possess analgesic and anti-inflammatory properties by inhibiting cyclooxygenase (COX) enzymes. Conflicting evidence exists on whether NSAIDs influence signaling related to muscle adaptations and exercise with some research finding a reduction...
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| Veröffentlicht in: | European journal of applied physiology 2024-12, Vol.124 (12), p.3607-3617 |
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| creator | Roberts, Brandon M. Geddis, Alyssa V. Sczuroski, Cara E. Reynoso, Marinaliz Hughes, Julie M. Gwin, Jess A. Staab, Jeffery S. |
| description | Background
Non-steroidal anti-inflammatory drugs (NSAIDs) possess analgesic and anti-inflammatory properties by inhibiting cyclooxygenase (COX) enzymes. Conflicting evidence exists on whether NSAIDs influence signaling related to muscle adaptations and exercise with some research finding a reduction in muscle protein synthesis signaling via the AKT-mTOR pathway, changes in satellite cell signaling, reductions in muscle protein degradation, and reductions in cell proliferation. In this study, we determined if a single maximal dose of flurbiprofen (FLU), celecoxib (CEL), ibuprofen (IBU), or a placebo (PLA) affects the short-term muscle signaling responses to plyometric exercise.
Methods
This was a block randomized, double-masked, crossover design, where 12 participants performed four plyometric exercise bouts consisting of 10 sets of 10 plyometric jumps at 40% 1RM. Two hours before exercise, participants consumed a single dose of celecoxib (CEL 200 mg), IBU (800 mg), FLU (100 mg) or PLA with food. Muscle biopsy samples were collected before and 3-h after exercise from the vastus lateralis. Data were analyzed using a repeated measures (RM) ANOVA, ANOVA, or a Friedman test. Significance was considered at
p
0.05). We also found no treatment effects on AKT-mTOR signaling or MAPK signaling measured through the phosphorylation status of mTORS2441, mTORS2448, RPS6 235/236, RPS 240/244, 4EBP1, ERK1/2, p38 T180/182 normalized to their respective total abundance (all,
p
> 0.05). However, we did find a significant difference between MNK1 T197/202 in PLA compared to FLU (
p
|
| doi_str_mv | 10.1007/s00421-024-05565-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3084032109</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3084032109</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-b5bba453429b0984f3421e3cdf545e5e90214e81d69d62c0fe54fd2d3a4026a83</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxiMEoqXwAhyQJS4cNjD-lybHqgKKVKmX9mw59mQ3lRMvdiztPgzvykBKkXroyaOZ33zWN19VvefwmQOcf8kASvAahKpB60bX-kV1ypXs6kaK85ePNe9Oqjc53wNAK3j7ujqRHSgFEk6rXxcsj_M24IZN9jBONjAfM7I4MIcBXTyM_YaNfdmnOOC8YTGxIZTUj2uDaMxsjgtL6ItDtuyQTSW7gCS8nW0IJE_DvI8z6S6R7cMxTrik0TE8YHIjtceZHWMhcIc2LLsjs76EJb-tXg02ZHz38J5Vd9--3l5e1dc3339cXlzXTuhmqXvd91ZpqUTXQ9eqgSqO0vlBK40aOxBcYct90_lGOBhQq8ELL60C0dhWnlWfVl0y9bNgXsw0ZvIf7IyxZCOhpXMJDh2hH5-g97Ek8kkUFx1oKZQgSqyUSzHnhIPZJzpuOhoO5k94Zg3PUHjmb3hG09KHB-nST-gfV_6lRYBcgUyjeYvp_9_PyP4G7Dimwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3129053242</pqid></control><display><type>article</type><title>A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults</title><source>MEDLINE</source><source>SpringerLink_现刊</source><creator>Roberts, Brandon M. ; Geddis, Alyssa V. ; Sczuroski, Cara E. ; Reynoso, Marinaliz ; Hughes, Julie M. ; Gwin, Jess A. ; Staab, Jeffery S.</creator><creatorcontrib>Roberts, Brandon M. ; Geddis, Alyssa V. ; Sczuroski, Cara E. ; Reynoso, Marinaliz ; Hughes, Julie M. ; Gwin, Jess A. ; Staab, Jeffery S.</creatorcontrib><description>Background
Non-steroidal anti-inflammatory drugs (NSAIDs) possess analgesic and anti-inflammatory properties by inhibiting cyclooxygenase (COX) enzymes. Conflicting evidence exists on whether NSAIDs influence signaling related to muscle adaptations and exercise with some research finding a reduction in muscle protein synthesis signaling via the AKT-mTOR pathway, changes in satellite cell signaling, reductions in muscle protein degradation, and reductions in cell proliferation. In this study, we determined if a single maximal dose of flurbiprofen (FLU), celecoxib (CEL), ibuprofen (IBU), or a placebo (PLA) affects the short-term muscle signaling responses to plyometric exercise.
Methods
This was a block randomized, double-masked, crossover design, where 12 participants performed four plyometric exercise bouts consisting of 10 sets of 10 plyometric jumps at 40% 1RM. Two hours before exercise, participants consumed a single dose of celecoxib (CEL 200 mg), IBU (800 mg), FLU (100 mg) or PLA with food. Muscle biopsy samples were collected before and 3-h after exercise from the vastus lateralis. Data were analyzed using a repeated measures (RM) ANOVA, ANOVA, or a Friedman test. Significance was considered at
p
< 0.05.
Results
We found no treatment effects on the mRNA expression of
PTSG1, PTSG2, MYC, TBP, RPLOP, MYOD1, Pax7, MYOG
,
Atrogin-1
, or
MURF1
(all,
p
> 0.05). We also found no treatment effects on AKT-mTOR signaling or MAPK signaling measured through the phosphorylation status of mTORS2441, mTORS2448, RPS6 235/236, RPS 240/244, 4EBP1, ERK1/2, p38 T180/182 normalized to their respective total abundance (all,
p
> 0.05). However, we did find a significant difference between MNK1 T197/202 in PLA compared to FLU (
p
< .05).
Conclusion
A single, maximal dose of IBU, CEL, or FLU taken prior to exercise did not affect the signaling of muscle protein synthesis, protein degradation, or ribosome biogenesis three hours after a plyometric training bout.</description><identifier>ISSN: 1439-6319</identifier><identifier>ISSN: 1439-6327</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-024-05565-5</identifier><identifier>PMID: 39044030</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; AKT protein ; Analgesics ; Anti-inflammatory agents ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Biomedical and Life Sciences ; Biomedicine ; Biopsy ; Celecoxib ; Celecoxib - administration & dosage ; Celecoxib - pharmacology ; Cell proliferation ; Cell signaling ; Cross-Over Studies ; Double-Blind Method ; Exercise - physiology ; Extracellular signal-regulated kinase ; Female ; Flurbiprofen ; Flurbiprofen - administration & dosage ; Flurbiprofen - pharmacology ; Gene expression ; Human Physiology ; Humans ; Ibuprofen ; Ibuprofen - administration & dosage ; Ibuprofen - pharmacology ; Inflammation ; Influenza ; Male ; MAP kinase ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Myc protein ; Nonsteroidal anti-inflammatory drugs ; Occupational Medicine/Industrial Medicine ; Original Article ; Phospholipase A ; Phosphorylation ; Prostaglandin endoperoxide synthase ; Protein biosynthesis ; Protein synthesis ; Proteins ; Satellite cells ; Signal transduction ; Signal Transduction - drug effects ; Sports Medicine ; TOR protein ; Young Adult</subject><ispartof>European journal of applied physiology, 2024-12, Vol.124 (12), p.3607-3617</ispartof><rights>This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024</rights><rights>2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.</rights><rights>This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-b5bba453429b0984f3421e3cdf545e5e90214e81d69d62c0fe54fd2d3a4026a83</cites><orcidid>0000-0003-0395-6967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-024-05565-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-024-05565-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39044030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, Brandon M.</creatorcontrib><creatorcontrib>Geddis, Alyssa V.</creatorcontrib><creatorcontrib>Sczuroski, Cara E.</creatorcontrib><creatorcontrib>Reynoso, Marinaliz</creatorcontrib><creatorcontrib>Hughes, Julie M.</creatorcontrib><creatorcontrib>Gwin, Jess A.</creatorcontrib><creatorcontrib>Staab, Jeffery S.</creatorcontrib><title>A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Background
Non-steroidal anti-inflammatory drugs (NSAIDs) possess analgesic and anti-inflammatory properties by inhibiting cyclooxygenase (COX) enzymes. Conflicting evidence exists on whether NSAIDs influence signaling related to muscle adaptations and exercise with some research finding a reduction in muscle protein synthesis signaling via the AKT-mTOR pathway, changes in satellite cell signaling, reductions in muscle protein degradation, and reductions in cell proliferation. In this study, we determined if a single maximal dose of flurbiprofen (FLU), celecoxib (CEL), ibuprofen (IBU), or a placebo (PLA) affects the short-term muscle signaling responses to plyometric exercise.
Methods
This was a block randomized, double-masked, crossover design, where 12 participants performed four plyometric exercise bouts consisting of 10 sets of 10 plyometric jumps at 40% 1RM. Two hours before exercise, participants consumed a single dose of celecoxib (CEL 200 mg), IBU (800 mg), FLU (100 mg) or PLA with food. Muscle biopsy samples were collected before and 3-h after exercise from the vastus lateralis. Data were analyzed using a repeated measures (RM) ANOVA, ANOVA, or a Friedman test. Significance was considered at
p
< 0.05.
Results
We found no treatment effects on the mRNA expression of
PTSG1, PTSG2, MYC, TBP, RPLOP, MYOD1, Pax7, MYOG
,
Atrogin-1
, or
MURF1
(all,
p
> 0.05). We also found no treatment effects on AKT-mTOR signaling or MAPK signaling measured through the phosphorylation status of mTORS2441, mTORS2448, RPS6 235/236, RPS 240/244, 4EBP1, ERK1/2, p38 T180/182 normalized to their respective total abundance (all,
p
> 0.05). However, we did find a significant difference between MNK1 T197/202 in PLA compared to FLU (
p
< .05).
Conclusion
A single, maximal dose of IBU, CEL, or FLU taken prior to exercise did not affect the signaling of muscle protein synthesis, protein degradation, or ribosome biogenesis three hours after a plyometric training bout.</description><subject>Adult</subject><subject>AKT protein</subject><subject>Analgesics</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopsy</subject><subject>Celecoxib</subject><subject>Celecoxib - administration & dosage</subject><subject>Celecoxib - pharmacology</subject><subject>Cell proliferation</subject><subject>Cell signaling</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Exercise - physiology</subject><subject>Extracellular signal-regulated kinase</subject><subject>Female</subject><subject>Flurbiprofen</subject><subject>Flurbiprofen - administration & dosage</subject><subject>Flurbiprofen - pharmacology</subject><subject>Gene expression</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Ibuprofen</subject><subject>Ibuprofen - administration & dosage</subject><subject>Ibuprofen - pharmacology</subject><subject>Inflammation</subject><subject>Influenza</subject><subject>Male</subject><subject>MAP kinase</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Myc protein</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Phospholipase A</subject><subject>Phosphorylation</subject><subject>Prostaglandin endoperoxide synthase</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Satellite cells</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Sports Medicine</subject><subject>TOR protein</subject><subject>Young Adult</subject><issn>1439-6319</issn><issn>1439-6327</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEoqXwAhyQJS4cNjD-lybHqgKKVKmX9mw59mQ3lRMvdiztPgzvykBKkXroyaOZ33zWN19VvefwmQOcf8kASvAahKpB60bX-kV1ypXs6kaK85ePNe9Oqjc53wNAK3j7ujqRHSgFEk6rXxcsj_M24IZN9jBONjAfM7I4MIcBXTyM_YaNfdmnOOC8YTGxIZTUj2uDaMxsjgtL6ItDtuyQTSW7gCS8nW0IJE_DvI8z6S6R7cMxTrik0TE8YHIjtceZHWMhcIc2LLsjs76EJb-tXg02ZHz38J5Vd9--3l5e1dc3339cXlzXTuhmqXvd91ZpqUTXQ9eqgSqO0vlBK40aOxBcYct90_lGOBhQq8ELL60C0dhWnlWfVl0y9bNgXsw0ZvIf7IyxZCOhpXMJDh2hH5-g97Ek8kkUFx1oKZQgSqyUSzHnhIPZJzpuOhoO5k94Zg3PUHjmb3hG09KHB-nST-gfV_6lRYBcgUyjeYvp_9_PyP4G7Dimwg</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Roberts, Brandon M.</creator><creator>Geddis, Alyssa V.</creator><creator>Sczuroski, Cara E.</creator><creator>Reynoso, Marinaliz</creator><creator>Hughes, Julie M.</creator><creator>Gwin, Jess A.</creator><creator>Staab, Jeffery S.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0395-6967</orcidid></search><sort><creationdate>20241201</creationdate><title>A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults</title><author>Roberts, Brandon M. ; Geddis, Alyssa V. ; Sczuroski, Cara E. ; Reynoso, Marinaliz ; Hughes, Julie M. ; Gwin, Jess A. ; Staab, Jeffery S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-b5bba453429b0984f3421e3cdf545e5e90214e81d69d62c0fe54fd2d3a4026a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>AKT protein</topic><topic>Analgesics</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biopsy</topic><topic>Celecoxib</topic><topic>Celecoxib - administration & dosage</topic><topic>Celecoxib - pharmacology</topic><topic>Cell proliferation</topic><topic>Cell signaling</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Exercise - physiology</topic><topic>Extracellular signal-regulated kinase</topic><topic>Female</topic><topic>Flurbiprofen</topic><topic>Flurbiprofen - administration & dosage</topic><topic>Flurbiprofen - pharmacology</topic><topic>Gene expression</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Ibuprofen</topic><topic>Ibuprofen - administration & dosage</topic><topic>Ibuprofen - pharmacology</topic><topic>Inflammation</topic><topic>Influenza</topic><topic>Male</topic><topic>MAP kinase</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Myc protein</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Phospholipase A</topic><topic>Phosphorylation</topic><topic>Prostaglandin endoperoxide synthase</topic><topic>Protein biosynthesis</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Satellite cells</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Sports Medicine</topic><topic>TOR protein</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, Brandon M.</creatorcontrib><creatorcontrib>Geddis, Alyssa V.</creatorcontrib><creatorcontrib>Sczuroski, Cara E.</creatorcontrib><creatorcontrib>Reynoso, Marinaliz</creatorcontrib><creatorcontrib>Hughes, Julie M.</creatorcontrib><creatorcontrib>Gwin, Jess A.</creatorcontrib><creatorcontrib>Staab, Jeffery S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, Brandon M.</au><au>Geddis, Alyssa V.</au><au>Sczuroski, Cara E.</au><au>Reynoso, Marinaliz</au><au>Hughes, Julie M.</au><au>Gwin, Jess A.</au><au>Staab, Jeffery S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>124</volume><issue>12</issue><spage>3607</spage><epage>3617</epage><pages>3607-3617</pages><issn>1439-6319</issn><issn>1439-6327</issn><eissn>1439-6327</eissn><abstract>Background
Non-steroidal anti-inflammatory drugs (NSAIDs) possess analgesic and anti-inflammatory properties by inhibiting cyclooxygenase (COX) enzymes. Conflicting evidence exists on whether NSAIDs influence signaling related to muscle adaptations and exercise with some research finding a reduction in muscle protein synthesis signaling via the AKT-mTOR pathway, changes in satellite cell signaling, reductions in muscle protein degradation, and reductions in cell proliferation. In this study, we determined if a single maximal dose of flurbiprofen (FLU), celecoxib (CEL), ibuprofen (IBU), or a placebo (PLA) affects the short-term muscle signaling responses to plyometric exercise.
Methods
This was a block randomized, double-masked, crossover design, where 12 participants performed four plyometric exercise bouts consisting of 10 sets of 10 plyometric jumps at 40% 1RM. Two hours before exercise, participants consumed a single dose of celecoxib (CEL 200 mg), IBU (800 mg), FLU (100 mg) or PLA with food. Muscle biopsy samples were collected before and 3-h after exercise from the vastus lateralis. Data were analyzed using a repeated measures (RM) ANOVA, ANOVA, or a Friedman test. Significance was considered at
p
< 0.05.
Results
We found no treatment effects on the mRNA expression of
PTSG1, PTSG2, MYC, TBP, RPLOP, MYOD1, Pax7, MYOG
,
Atrogin-1
, or
MURF1
(all,
p
> 0.05). We also found no treatment effects on AKT-mTOR signaling or MAPK signaling measured through the phosphorylation status of mTORS2441, mTORS2448, RPS6 235/236, RPS 240/244, 4EBP1, ERK1/2, p38 T180/182 normalized to their respective total abundance (all,
p
> 0.05). However, we did find a significant difference between MNK1 T197/202 in PLA compared to FLU (
p
< .05).
Conclusion
A single, maximal dose of IBU, CEL, or FLU taken prior to exercise did not affect the signaling of muscle protein synthesis, protein degradation, or ribosome biogenesis three hours after a plyometric training bout.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39044030</pmid><doi>10.1007/s00421-024-05565-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0395-6967</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2024-12, Vol.124 (12), p.3607-3617 |
| issn | 1439-6319 1439-6327 1439-6327 |
| language | eng |
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| subjects | Adult AKT protein Analgesics Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biomedical and Life Sciences Biomedicine Biopsy Celecoxib Celecoxib - administration & dosage Celecoxib - pharmacology Cell proliferation Cell signaling Cross-Over Studies Double-Blind Method Exercise - physiology Extracellular signal-regulated kinase Female Flurbiprofen Flurbiprofen - administration & dosage Flurbiprofen - pharmacology Gene expression Human Physiology Humans Ibuprofen Ibuprofen - administration & dosage Ibuprofen - pharmacology Inflammation Influenza Male MAP kinase Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Myc protein Nonsteroidal anti-inflammatory drugs Occupational Medicine/Industrial Medicine Original Article Phospholipase A Phosphorylation Prostaglandin endoperoxide synthase Protein biosynthesis Protein synthesis Proteins Satellite cells Signal transduction Signal Transduction - drug effects Sports Medicine TOR protein Young Adult |
| title | A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults |
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