Boosting immunity: synergistic antiviral effects of luteolin, vitamin C, magnesium and zinc against SARS-CoV-2 3CLpro

SARS-CoV-2 was first discovered in 2019 and has disseminated throughout the globe to pandemic levels, imposing significant health and economic burdens. Although vaccines against SARS-CoV-2 have been developed, their long-term efficacy and specificity have not been determined, and antiviral drugs rem...

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Veröffentlicht in:	Bioscience reports 2024-08, Vol.44 (8)
Hauptverfasser:	Ferreira, Juliana C, Fadl, Samar, Cardoso, Thyago H S, Andrade, Bruno Silva, Melo, Tarcisio S, Silva, Edson Mario de Andrade, Agarwal, Anupriya, Turville, Stuart J, Saksena, Nitin K, Rabeh, Wael M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral activity Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Ascorbic acid Ascorbic Acid - pharmacology Biological effects Chymotrypsin Clinical trials Cluster analysis Competition Coronavirus 3C Proteases - antagonists & inhibitors Coronavirus 3C Proteases - metabolism COVID-19 COVID-19 - immunology COVID-19 - virology COVID-19 Drug Treatment Disease transmission Drug Synergism Effectiveness FDA approval Flavonoids Humans Immune system Immunity (Disease) Infections Libraries Luteolin - pharmacology Magnesium Magnesium - pharmacology Metal ions Middle East respiratory syndrome Molecular docking Molecular Docking Simulation Molecular dynamics Molecular Dynamics Simulation Pandemics Peptides Pharmacology Phytochemicals Plants (botany) Protease Proteins Respiratory diseases SARS-CoV-2 - drug effects SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Stability Stability analysis Thermodynamics Viral diseases Viral infections Viruses Vitamin C Zinc Zinc - chemistry Zinc - pharmacology
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