Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module

Small cell lung cancer (SCLC) is a recalcitrant malignancy with dismal prognosis due to rapid relapse after an initial treatment response. More effective treatments for SCLC are desperately needed. Our previous studies showed that cell migration-inducing hyaluronan binding protein (CEMIP) functional...

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Veröffentlicht in:	Acta pharmacologica Sinica 2024-12, Vol.45 (12), p.2657-2671
Hauptverfasser:	Shen, Xiao-ju, Wei, Hui-lan, Mo, Xiao-cheng, Mo, Xiao-xiang, Li, Li, He, Jing-chuan, Wei, Xin-yu, Qin, Xiao-jun, Xing, Shang-ping, Luo, Zhuo, Chen, Zhi-quan, Yang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cell Line, Tumor Cell Proliferation - drug effects Cisplatin - pharmacology Cisplatin - therapeutic use Drug Resistance, Neoplasm - drug effects Etoposide - pharmacology Humans Immunology Internal Medicine Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical Microbiology Mice Mice, Inbred BALB C Mice, Nude Pharmacology/Toxicology Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - metabolism Small Cell Lung Carcinoma - pathology src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism Transcription Factors - metabolism Vaccine Xenograft Model Antitumor Assays YAP-Signaling Proteins - metabolism
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