Circulating CD8 + LGALS9 + T Cell Population Exhibiting Low Cytotoxic Characteristics are Decreased in Patients with Systemic Lupus Erythematosus
LGALS9, also known as Galectin-9 and a member of the β-galactosidase family, plays a crucial role in immune regulation. However, its expression and function in CD8 T cells, as well as its association with cytotoxic T lymphocytes (CTL), remain unclear. This study aims to investigate LGALS9 expression...
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| Veröffentlicht in: | Immunologic research 2024-12, Vol.72 (6), p.1238-1246 |
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| creator | Li, Qi Wang, Guochong Yuan, Zihang Kang, Rui Li, Yaxin Bahabayi, Ayibaota Xiong, Ziqi Zhang, Zhonghui Liu, Chen |
| description | LGALS9, also known as Galectin-9 and a member of the β-galactosidase family, plays a crucial role in immune regulation. However, its expression and function in CD8 T cells, as well as its association with cytotoxic T lymphocytes (CTL), remain unclear. This study aims to investigate LGALS9 expression patterns in human circulating CD8 T lymphocytes and elucidate its clinical significance in Systemic Lupus Erythematosus (SLE). Blood samples from 56 healthy controls and 50 new-onset SLE patients were collected. Flow cytometry was utilized to analyze LGALS9 expression in circulating CD8 T lymphocytes via intracellular staining. Compared to LGALS9 + CD8 + T cells, LGALS9-CD8 + T cells showed increased secretion of Granzyme B (GZMB) and Perforin, along with elevated expression levels of GPR56, CX3CR1, KLRD1, KLRF1, PD1, and CD29. A higher proportion of Tn (naive T cells) and TCM (central memory T cells) showed LGALS9 positivity, compared to TEM (effector memory T cells) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA). Clinically, the downregulation of LGALS9 expression was significant in SLE patients. LGALS9 + CD8 + T cells exhibited an Area Under the Curve (AUC) of 0.6916, while CX3CR1 + in LGALS9 + CD8 + T cells had an AUC of 0.6478, and KLRF1 + had an AUC of 0.6419, for distinguishing SLE from healthy individuals. In conclusion, CD8 + LGALS9 + T cells display characteristics of low cytotoxicity, and their reduction is evident in SLE patients, potentially implicating them in SLE pathogenesis and providing diagnostic assistance. |
| doi_str_mv | 10.1007/s12026-024-09522-4 |
| format | Article |
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However, its expression and function in CD8 T cells, as well as its association with cytotoxic T lymphocytes (CTL), remain unclear. This study aims to investigate LGALS9 expression patterns in human circulating CD8 T lymphocytes and elucidate its clinical significance in Systemic Lupus Erythematosus (SLE). Blood samples from 56 healthy controls and 50 new-onset SLE patients were collected. Flow cytometry was utilized to analyze LGALS9 expression in circulating CD8 T lymphocytes via intracellular staining. Compared to LGALS9 + CD8 + T cells, LGALS9-CD8 + T cells showed increased secretion of Granzyme B (GZMB) and Perforin, along with elevated expression levels of GPR56, CX3CR1, KLRD1, KLRF1, PD1, and CD29. A higher proportion of Tn (naive T cells) and TCM (central memory T cells) showed LGALS9 positivity, compared to TEM (effector memory T cells) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA). Clinically, the downregulation of LGALS9 expression was significant in SLE patients. LGALS9 + CD8 + T cells exhibited an Area Under the Curve (AUC) of 0.6916, while CX3CR1 + in LGALS9 + CD8 + T cells had an AUC of 0.6478, and KLRF1 + had an AUC of 0.6419, for distinguishing SLE from healthy individuals. In conclusion, CD8 + LGALS9 + T cells display characteristics of low cytotoxicity, and their reduction is evident in SLE patients, potentially implicating them in SLE pathogenesis and providing diagnostic assistance.</description><identifier>ISSN: 0257-277X</identifier><identifier>ISSN: 1559-0755</identifier><identifier>EISSN: 1559-0755</identifier><identifier>DOI: 10.1007/s12026-024-09522-4</identifier><identifier>PMID: 39046608</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Allergology ; Biomedical and Life Sciences ; Biomedicine ; CD29 antigen ; CD45RA antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Cell differentiation ; CX3CR1 protein ; Cytotoxicity ; Cytotoxicity, Immunologic ; Effector cells ; family ; Female ; Flow cytometry ; Galectin-9 ; galectins ; Galectins - metabolism ; Granzyme B ; Granzymes - metabolism ; Humans ; Immunological memory ; Immunology ; Immunoregulation ; Internal Medicine ; Lupus ; lupus erythematosus ; Lupus Erythematosus, Systemic - immunology ; Lymphocytes ; Lymphocytes T ; Male ; Medicine/Public Health ; memory ; Memory cells ; Middle Aged ; pathogenesis ; PD-1 protein ; Perforin ; Perforin - metabolism ; secretion ; Systemic lupus erythematosus ; T-lymphocytes ; T-Lymphocytes, Cytotoxic - immunology ; Young Adult ; β-Galactosidase</subject><ispartof>Immunologic research, 2024-12, Vol.72 (6), p.1238-1246</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Dec 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-e67617df0581aa453485f7292985711129799b7e9019658dd9b6fc368eb3bcc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12026-024-09522-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12026-024-09522-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39046608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Wang, Guochong</creatorcontrib><creatorcontrib>Yuan, Zihang</creatorcontrib><creatorcontrib>Kang, Rui</creatorcontrib><creatorcontrib>Li, Yaxin</creatorcontrib><creatorcontrib>Bahabayi, Ayibaota</creatorcontrib><creatorcontrib>Xiong, Ziqi</creatorcontrib><creatorcontrib>Zhang, Zhonghui</creatorcontrib><creatorcontrib>Liu, Chen</creatorcontrib><title>Circulating CD8 + LGALS9 + T Cell Population Exhibiting Low Cytotoxic Characteristics are Decreased in Patients with Systemic Lupus Erythematosus</title><title>Immunologic research</title><addtitle>Immunol Res</addtitle><addtitle>Immunol Res</addtitle><description>LGALS9, also known as Galectin-9 and a member of the β-galactosidase family, plays a crucial role in immune regulation. However, its expression and function in CD8 T cells, as well as its association with cytotoxic T lymphocytes (CTL), remain unclear. This study aims to investigate LGALS9 expression patterns in human circulating CD8 T lymphocytes and elucidate its clinical significance in Systemic Lupus Erythematosus (SLE). Blood samples from 56 healthy controls and 50 new-onset SLE patients were collected. Flow cytometry was utilized to analyze LGALS9 expression in circulating CD8 T lymphocytes via intracellular staining. Compared to LGALS9 + CD8 + T cells, LGALS9-CD8 + T cells showed increased secretion of Granzyme B (GZMB) and Perforin, along with elevated expression levels of GPR56, CX3CR1, KLRD1, KLRF1, PD1, and CD29. A higher proportion of Tn (naive T cells) and TCM (central memory T cells) showed LGALS9 positivity, compared to TEM (effector memory T cells) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA). Clinically, the downregulation of LGALS9 expression was significant in SLE patients. LGALS9 + CD8 + T cells exhibited an Area Under the Curve (AUC) of 0.6916, while CX3CR1 + in LGALS9 + CD8 + T cells had an AUC of 0.6478, and KLRF1 + had an AUC of 0.6419, for distinguishing SLE from healthy individuals. In conclusion, CD8 + LGALS9 + T cells display characteristics of low cytotoxicity, and their reduction is evident in SLE patients, potentially implicating them in SLE pathogenesis and providing diagnostic assistance.</description><subject>Adult</subject><subject>Allergology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CD29 antigen</subject><subject>CD45RA antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cell differentiation</subject><subject>CX3CR1 protein</subject><subject>Cytotoxicity</subject><subject>Cytotoxicity, Immunologic</subject><subject>Effector cells</subject><subject>family</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Galectin-9</subject><subject>galectins</subject><subject>Galectins - metabolism</subject><subject>Granzyme B</subject><subject>Granzymes - metabolism</subject><subject>Humans</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Immunoregulation</subject><subject>Internal Medicine</subject><subject>Lupus</subject><subject>lupus erythematosus</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine/Public Health</subject><subject>memory</subject><subject>Memory cells</subject><subject>Middle Aged</subject><subject>pathogenesis</subject><subject>PD-1 protein</subject><subject>Perforin</subject><subject>Perforin - metabolism</subject><subject>secretion</subject><subject>Systemic lupus erythematosus</subject><subject>T-lymphocytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Young Adult</subject><subject>β-Galactosidase</subject><issn>0257-277X</issn><issn>1559-0755</issn><issn>1559-0755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFDEYhwex2LX6BTxIwIsgo2_-J8cyXasw0EIreBsymUw3ZWdmTTK0e_PqR_Dr-UlMd1cFD3oIIeT5PS8vv6J4geEtBpDvIiZARAmElaA5ISV7VCww57oEyfnjYgGEy5JI-fm4eBrjLQAWjNEnxTHVwIQAtSi-Vz7YeW2SH29QdaZ-fP32Jp_6_LS-0ofHNarceo0up80OnEa0vF_51u8y9XSHqm2a0nTvLapWJhibXPAxeRuRCQ6dORucia5DfkSXWeDGFNGdTyt0tY3JDTlXz5s5omXYppUbTJriHJ8VR71ZR_f8cJ8Un94vr6sPZX1x_rE6rUtLlE6lE1Jg2fXAFTaGccoU7yXRRCsuMcZES61b6TRgLbjqOt2K3lKhXEtba4GeFK_33k2Yvswupmbw0eaFzeimOTYUc0aowpz8HwXFgGIiaEZf_YXeTnMY8yJZyEAqoPAwm-wpG6YYg-ubTfCDCdsGQ_PQcbPvuMkdN7uOG5ZDLw_quR1c9zvyq9QM0D0Q89d448Kf2f_Q_gQ6pbSX</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Li, Qi</creator><creator>Wang, Guochong</creator><creator>Yuan, Zihang</creator><creator>Kang, Rui</creator><creator>Li, Yaxin</creator><creator>Bahabayi, Ayibaota</creator><creator>Xiong, Ziqi</creator><creator>Zhang, Zhonghui</creator><creator>Liu, Chen</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20241201</creationdate><title>Circulating CD8 + LGALS9 + T Cell Population Exhibiting Low Cytotoxic Characteristics are Decreased in Patients with Systemic Lupus Erythematosus</title><author>Li, Qi ; Wang, Guochong ; Yuan, Zihang ; Kang, Rui ; Li, Yaxin ; Bahabayi, Ayibaota ; Xiong, Ziqi ; Zhang, Zhonghui ; Liu, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-e67617df0581aa453485f7292985711129799b7e9019658dd9b6fc368eb3bcc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Allergology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CD29 antigen</topic><topic>CD45RA antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cell differentiation</topic><topic>CX3CR1 protein</topic><topic>Cytotoxicity</topic><topic>Cytotoxicity, Immunologic</topic><topic>Effector cells</topic><topic>family</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Galectin-9</topic><topic>galectins</topic><topic>Galectins - metabolism</topic><topic>Granzyme B</topic><topic>Granzymes - metabolism</topic><topic>Humans</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Immunoregulation</topic><topic>Internal Medicine</topic><topic>Lupus</topic><topic>lupus erythematosus</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medicine/Public Health</topic><topic>memory</topic><topic>Memory cells</topic><topic>Middle Aged</topic><topic>pathogenesis</topic><topic>PD-1 protein</topic><topic>Perforin</topic><topic>Perforin - metabolism</topic><topic>secretion</topic><topic>Systemic lupus erythematosus</topic><topic>T-lymphocytes</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Young Adult</topic><topic>β-Galactosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Wang, Guochong</creatorcontrib><creatorcontrib>Yuan, Zihang</creatorcontrib><creatorcontrib>Kang, Rui</creatorcontrib><creatorcontrib>Li, Yaxin</creatorcontrib><creatorcontrib>Bahabayi, Ayibaota</creatorcontrib><creatorcontrib>Xiong, Ziqi</creatorcontrib><creatorcontrib>Zhang, Zhonghui</creatorcontrib><creatorcontrib>Liu, Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Immunologic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qi</au><au>Wang, Guochong</au><au>Yuan, Zihang</au><au>Kang, Rui</au><au>Li, Yaxin</au><au>Bahabayi, Ayibaota</au><au>Xiong, Ziqi</au><au>Zhang, Zhonghui</au><au>Liu, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating CD8 + LGALS9 + T Cell Population Exhibiting Low Cytotoxic Characteristics are Decreased in Patients with Systemic Lupus Erythematosus</atitle><jtitle>Immunologic research</jtitle><stitle>Immunol Res</stitle><addtitle>Immunol Res</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>72</volume><issue>6</issue><spage>1238</spage><epage>1246</epage><pages>1238-1246</pages><issn>0257-277X</issn><issn>1559-0755</issn><eissn>1559-0755</eissn><abstract>LGALS9, also known as Galectin-9 and a member of the β-galactosidase family, plays a crucial role in immune regulation. However, its expression and function in CD8 T cells, as well as its association with cytotoxic T lymphocytes (CTL), remain unclear. This study aims to investigate LGALS9 expression patterns in human circulating CD8 T lymphocytes and elucidate its clinical significance in Systemic Lupus Erythematosus (SLE). Blood samples from 56 healthy controls and 50 new-onset SLE patients were collected. Flow cytometry was utilized to analyze LGALS9 expression in circulating CD8 T lymphocytes via intracellular staining. Compared to LGALS9 + CD8 + T cells, LGALS9-CD8 + T cells showed increased secretion of Granzyme B (GZMB) and Perforin, along with elevated expression levels of GPR56, CX3CR1, KLRD1, KLRF1, PD1, and CD29. A higher proportion of Tn (naive T cells) and TCM (central memory T cells) showed LGALS9 positivity, compared to TEM (effector memory T cells) and TEMRA (terminally differentiated effector memory T cells re-expressing CD45RA). Clinically, the downregulation of LGALS9 expression was significant in SLE patients. LGALS9 + CD8 + T cells exhibited an Area Under the Curve (AUC) of 0.6916, while CX3CR1 + in LGALS9 + CD8 + T cells had an AUC of 0.6478, and KLRF1 + had an AUC of 0.6419, for distinguishing SLE from healthy individuals. In conclusion, CD8 + LGALS9 + T cells display characteristics of low cytotoxicity, and their reduction is evident in SLE patients, potentially implicating them in SLE pathogenesis and providing diagnostic assistance.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39046608</pmid><doi>10.1007/s12026-024-09522-4</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Allergology Biomedical and Life Sciences Biomedicine CD29 antigen CD45RA antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell differentiation CX3CR1 protein Cytotoxicity Cytotoxicity, Immunologic Effector cells family Female Flow cytometry Galectin-9 galectins Galectins - metabolism Granzyme B Granzymes - metabolism Humans Immunological memory Immunology Immunoregulation Internal Medicine Lupus lupus erythematosus Lupus Erythematosus, Systemic - immunology Lymphocytes Lymphocytes T Male Medicine/Public Health memory Memory cells Middle Aged pathogenesis PD-1 protein Perforin Perforin - metabolism secretion Systemic lupus erythematosus T-lymphocytes T-Lymphocytes, Cytotoxic - immunology Young Adult β-Galactosidase |
| title | Circulating CD8 + LGALS9 + T Cell Population Exhibiting Low Cytotoxic Characteristics are Decreased in Patients with Systemic Lupus Erythematosus |
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