Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity

Pseudomonas aeruginosa causes life-threatening infections especially in hospitalized patients and shows an increasing resistance to established antibiotics. A process known as quorum sensing (QS) enables the pathogen to collectively adapt to various environmental conditions. Disrupting this cell-to-...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-10, Vol.276, p.116685, Article 116685
Hauptverfasser:	Abdelsamie, Ahmed S., Hamed, Mostafa M., Schütz, Christian, Röhrig, Teresa, Kany, Andreas M., Schmelz, Stefan, Blankenfeldt, Wulf, Hirsch, Anna K.H., Hartmann, Rolf W., Empting, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Dose-Response Relationship, Drug Drug Discovery Humans Microbial Sensitivity Tests Molecular Structure Pseudomonas aeruginosa - drug effects Quorum Sensing - drug effects Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology
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