A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System
Oligodendrocyte precursor cells (OPCs) are a heterogeneous multipotent population in the central nervous system (CNS) that appear during embryogenesis and persist as resident cells in the adult brain parenchyma. OPCs could generate oligodendrocytes to participate in myelination. Recent advances have...
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| Veröffentlicht in: | Neuroscience bulletin 2024-10, Vol.40 (10), p.1573-1589 |
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| creator | Ma, Zexuan Zhang, Wei Wang, Chenmeng Su, Yixun Yi, Chenju Niu, Jianqin |
| description | Oligodendrocyte precursor cells (OPCs) are a heterogeneous multipotent population in the central nervous system (CNS) that appear during embryogenesis and persist as resident cells in the adult brain parenchyma. OPCs could generate oligodendrocytes to participate in myelination. Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells, the myelin-independent roles of OPCs, and the regulatory mechanism of OPC development. In this review, we will explore the updated knowledge on OPC identity, their multifaceted roles in the CNS in health and diseases, as well as the regulatory mechanisms that are involved in their developmental stages, which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology. |
| doi_str_mv | 10.1007/s12264-024-01261-8 |
| format | Article |
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OPCs could generate oligodendrocytes to participate in myelination. Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells, the myelin-independent roles of OPCs, and the regulatory mechanism of OPC development. In this review, we will explore the updated knowledge on OPC identity, their multifaceted roles in the CNS in health and diseases, as well as the regulatory mechanisms that are involved in their developmental stages, which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.</description><identifier>ISSN: 1673-7067</identifier><identifier>ISSN: 1995-8218</identifier><identifier>EISSN: 1995-8218</identifier><identifier>DOI: 10.1007/s12264-024-01261-8</identifier><identifier>PMID: 39042298</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Anatomy ; Anesthesiology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Differentiation - physiology ; Central Nervous System - cytology ; Central Nervous System - physiology ; Human Physiology ; Humans ; Myelin Sheath - physiology ; Neurology ; Neurosciences ; Oligodendrocyte Precursor Cells - cytology ; Oligodendrocyte Precursor Cells - physiology ; Oligodendroglia - physiology ; Pain Medicine ; Review</subject><ispartof>Neuroscience bulletin, 2024-10, Vol.40 (10), p.1573-1589</ispartof><rights>Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 2024. 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| ispartof | Neuroscience bulletin, 2024-10, Vol.40 (10), p.1573-1589 |
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| subjects | Anatomy Anesthesiology Animals Biomedical and Life Sciences Biomedicine Cell Differentiation - physiology Central Nervous System - cytology Central Nervous System - physiology Human Physiology Humans Myelin Sheath - physiology Neurology Neurosciences Oligodendrocyte Precursor Cells - cytology Oligodendrocyte Precursor Cells - physiology Oligodendroglia - physiology Pain Medicine Review |
| title | A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System |
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