CRABP2 promotes cell migration and invasion by activating PI3K/AKT and MAPK signalling pathways via upregulating LAMB3 in prostate cancer

Abstract Prostate cancer (PCa) has become a worldwide health burden among men. Previous studies have suggested that cellular retinoic acid binding protein 2 (CRABP2) significantly affects the regulation of cell proliferation, motility and apoptosis in multiple cancers; however, the effect of CRABP2...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2024-09, Vol.176 (4), p.313-324
Hauptverfasser:	Wang, Rui, Liao, Zhaoping, Liu, Chunhua, Yu, Shifang, Xiang, Kaihua, Wu, Ting, Feng, Jie, Ding, Senjuan, Yu, Tingao, Cheng, Gang, Li, Sanlian
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Cell adhesion & migration Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Gene expression Gene Expression Regulation, Neoplastic Humans Kalinin Kinases Laminin Male MAP kinase MAP Kinase Signaling System Mice Mice, Nude Neoplasm Invasiveness Phosphatidylinositol 3-Kinases - metabolism Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Retinoic acid Signal Transduction Up-Regulation
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