Geriatric nutritional risk index as a predictor for surgical site infection in malignant musculoskeletal tumours of the trunk

Surgical site infection (SSI) is common in surgery for malignant musculoskeletal tumours, specifically those arising from the trunk. In this study, we investigated the risk factors for SSI after resection of musculoskeletal tumours of the trunk. This retrospective observational study included 125 pa...

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Veröffentlicht in:	Japanese journal of clinical oncology 2024-11, Vol.54 (11), p.1158-1164
Hauptverfasser:	Shiraishi, Sakura, Fujiwara, Toshifumi, Nabeshima, Akira, Iida, Keiichiro, Endo, Makoto, Matsumoto, Yoshihiro, Oda, Yoshinao, Nakashima, Yasuharu
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Schlagworte:	Adult Aged Aged, 80 and over Bone Neoplasms - surgery Female Geriatric Assessment Humans Incidence Male Middle Aged Muscle Neoplasms - pathology Muscle Neoplasms - surgery Nutrition Assessment Nutritional Status Retrospective Studies Risk Factors Surgical Wound Infection - epidemiology Surgical Wound Infection - etiology Torso
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container_title	Japanese journal of clinical oncology
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creator	Shiraishi, Sakura Fujiwara, Toshifumi Nabeshima, Akira Iida, Keiichiro Endo, Makoto Matsumoto, Yoshihiro Oda, Yoshinao Nakashima, Yasuharu
description	Surgical site infection (SSI) is common in surgery for malignant musculoskeletal tumours, specifically those arising from the trunk. In this study, we investigated the risk factors for SSI after resection of musculoskeletal tumours of the trunk. This retrospective observational study included 125 patients (72 males, 53 females) with musculoskeletal tumours of the trunk in our hospital from 1 April 2008 to 31 August 2023. The incidence of SSI and its risk factors were investigated. SSI was observed in 26% (32/125), and the median time to SSI was 22 days. On multivariate analysis, the following were identified as risk factors for SSI: tumours arising caudal to Jacoby's line (hazard ratio [HR] 4.04; P = .0107), soft tissue reconstruction (HR 3.43; P = .0131), and low Geriatric Nutritional Risk Index (GNRI) (HR 0.96; P = .0304). Patients were classified into two risk categories based on GNRI scores: the risk group (GNRI ≤98) and no risk group (>98). The risk group showed a significantly lower overall noninfection survival rate (P = .023). Tumours arising caudal to Jacoby line, soft tissue reconstruction, and lower GNRI were risk factors for SSI. Preoperative and postoperative nutritional interventions should be considered to improve GNRI.
doi_str_mv	10.1093/jjco/hyae095
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In this study, we investigated the risk factors for SSI after resection of musculoskeletal tumours of the trunk. This retrospective observational study included 125 patients (72 males, 53 females) with musculoskeletal tumours of the trunk in our hospital from 1 April 2008 to 31 August 2023. The incidence of SSI and its risk factors were investigated. SSI was observed in 26% (32/125), and the median time to SSI was 22 days. On multivariate analysis, the following were identified as risk factors for SSI: tumours arising caudal to Jacoby's line (hazard ratio [HR] 4.04; P = .0107), soft tissue reconstruction (HR 3.43; P = .0131), and low Geriatric Nutritional Risk Index (GNRI) (HR 0.96; P = .0304). Patients were classified into two risk categories based on GNRI scores: the risk group (GNRI ≤98) and no risk group (>98). The risk group showed a significantly lower overall noninfection survival rate (P = .023). Tumours arising caudal to Jacoby line, soft tissue reconstruction, and lower GNRI were risk factors for SSI. Preoperative and postoperative nutritional interventions should be considered to improve GNRI.</description><identifier>ISSN: 1465-3621</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyae095</identifier><identifier>PMID: 39037963</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms - surgery ; Female ; Geriatric Assessment ; Humans ; Incidence ; Male ; Middle Aged ; Muscle Neoplasms - pathology ; Muscle Neoplasms - surgery ; Nutrition Assessment ; Nutritional Status ; Retrospective Studies ; Risk Factors ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - etiology ; Torso</subject><ispartof>Japanese journal of clinical oncology, 2024-11, Vol.54 (11), p.1158-1164</ispartof><rights>The Author(s) 2024. Published by Oxford University Press. 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In this study, we investigated the risk factors for SSI after resection of musculoskeletal tumours of the trunk. This retrospective observational study included 125 patients (72 males, 53 females) with musculoskeletal tumours of the trunk in our hospital from 1 April 2008 to 31 August 2023. The incidence of SSI and its risk factors were investigated. SSI was observed in 26% (32/125), and the median time to SSI was 22 days. On multivariate analysis, the following were identified as risk factors for SSI: tumours arising caudal to Jacoby's line (hazard ratio [HR] 4.04; P = .0107), soft tissue reconstruction (HR 3.43; P = .0131), and low Geriatric Nutritional Risk Index (GNRI) (HR 0.96; P = .0304). Patients were classified into two risk categories based on GNRI scores: the risk group (GNRI ≤98) and no risk group (>98). The risk group showed a significantly lower overall noninfection survival rate (P = .023). Tumours arising caudal to Jacoby line, soft tissue reconstruction, and lower GNRI were risk factors for SSI. Preoperative and postoperative nutritional interventions should be considered to improve GNRI.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Neoplasms - surgery</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Neoplasms - pathology</subject><subject>Muscle Neoplasms - surgery</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgical Wound Infection - epidemiology</subject><subject>Surgical Wound Infection - etiology</subject><subject>Torso</subject><issn>1465-3621</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkD1PwzAURS0EolDYmJFHBkLtOrHrEVVQkCqxwBy59nPrNomLPyQ68N9J1YIYnu4dzrvDQeiGkgdKJBut19qPVjsFRFYn6IKWvCoYH9PTf32ALmNcE0KqSSnO0YBJwoTk7AJ9zyA4lYLTuMt9JOc71eDg4ga7zsAXVhErvA1gnE4-YNtfzGHpdI9Fl6DHLOj9X99wqxq37FSXcJujzo2PG2gg9WzKrc8hYm9xWgFOIXebK3RmVRPh-phD9PH89D59KeZvs9fp47zQVExSwSs6NrbkTHDOQS2EMgvOCWghQEqjLaPSWs2BUFYyaiql5UIZy8oSuDKCDdHdYXcb_GeGmOrWRQ1NozrwOdaMTBgXpJKTHr0_oDr4GAPYehtcq8KupqTeC6_3wuuj8B6_PS7nRQvmD_41zH4A23SBmw</recordid><startdate>20241102</startdate><enddate>20241102</enddate><creator>Shiraishi, Sakura</creator><creator>Fujiwara, Toshifumi</creator><creator>Nabeshima, Akira</creator><creator>Iida, Keiichiro</creator><creator>Endo, Makoto</creator><creator>Matsumoto, Yoshihiro</creator><creator>Oda, Yoshinao</creator><creator>Nakashima, Yasuharu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0000-9471-1708</orcidid><orcidid>https://orcid.org/0000-0003-1720-407X</orcidid><orcidid>https://orcid.org/0000-0002-7956-2190</orcidid><orcidid>https://orcid.org/0000-0002-0039-2855</orcidid></search><sort><creationdate>20241102</creationdate><title>Geriatric nutritional risk index as a predictor for surgical site infection in malignant musculoskeletal tumours of the trunk</title><author>Shiraishi, Sakura ; 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In this study, we investigated the risk factors for SSI after resection of musculoskeletal tumours of the trunk. This retrospective observational study included 125 patients (72 males, 53 females) with musculoskeletal tumours of the trunk in our hospital from 1 April 2008 to 31 August 2023. The incidence of SSI and its risk factors were investigated. SSI was observed in 26% (32/125), and the median time to SSI was 22 days. On multivariate analysis, the following were identified as risk factors for SSI: tumours arising caudal to Jacoby's line (hazard ratio [HR] 4.04; P = .0107), soft tissue reconstruction (HR 3.43; P = .0131), and low Geriatric Nutritional Risk Index (GNRI) (HR 0.96; P = .0304). Patients were classified into two risk categories based on GNRI scores: the risk group (GNRI ≤98) and no risk group (>98). The risk group showed a significantly lower overall noninfection survival rate (P = .023). 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source	MEDLINE; Oxford University Press Journals All Titles (1996-Current)
subjects	Adult Aged Aged, 80 and over Bone Neoplasms - surgery Female Geriatric Assessment Humans Incidence Male Middle Aged Muscle Neoplasms - pathology Muscle Neoplasms - surgery Nutrition Assessment Nutritional Status Retrospective Studies Risk Factors Surgical Wound Infection - epidemiology Surgical Wound Infection - etiology Torso
title	Geriatric nutritional risk index as a predictor for surgical site infection in malignant musculoskeletal tumours of the trunk
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