Mitochondrial Control of Proteasomal Psmb5 Drives the Differentiation of Tissue‐Resident Memory T Cells in Patients with Rheumatoid Arthritis

Objective To explore T cell‐intrinsic mechanisms underpinning the mal‐differentiation of tissue‐resident memory T (Trm) cells in patients with rheumatoid arthritis (RA). Methods Circulating T cells from patient with RA and healthy individuals were used for Trm cell differentiation. The role of Hobit...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2024-12, Vol.76 (12), p.1743-1757
Hauptverfasser:	Wu, Tong, Su, Danhua, Zhang, Lei, Liu, Ting, Wang, Qianliang, Yan, Chenchu, Liu, Mengdi, Ji, Huiyan, Lei, Jiaxin, Zheng, Ming, Wen, Zhenke
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoimmune diseases CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Differentiation Chimeras Chromatin Differentiation (biology) Gene regulation Gene silencing Humans Immunological memory Immunoprecipitation Lymphocytes Lymphocytes T Male Memory cells Memory T Cells - immunology Mitochondria Mitochondria - metabolism Polymerase chain reaction Proteasome Endopeptidase Complex - metabolism Proteasomes Protein deficiency Rheumatoid arthritis Synovitis
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