Sepsis Impairs IFN-γ Production in CD8 T Cells through Changes in Local Chromatin Landscape

Sepsis is a complex condition of inflammatory and immune dysregulation, triggered by severe infection. In survivors, chronic inflammation and immune dysregulation linger, facilitating the emergence of infections. CD8 dysfunction contributes to immunosuppression in sepsis survivors. We devised an ani...

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Veröffentlicht in:	The Journal of immunology (1950) 2024-09, Vol.213 (5), p.619-627
Hauptverfasser:	Cisneros-Segura, J Alejandro, Rodríguez-Rodríguez, Noé, Albarrán-Godínez, Adrián, García-González, H Benjamín, Rodríguez-Osorio, Carlos A, Valdés-Ferrer, Sergio Iván, Tapia-Urzúa, Gustavo, Recillas-Targa, Félix, Madera-Salcedo, Iris K, Rosetti, Florencia, Crispín, José C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals CD8-Positive T-Lymphocytes - immunology Chromatin - immunology Chromatin - metabolism Disease Models, Animal Interferon-gamma - immunology Listeria monocytogenes - immunology Listeriosis - immunology Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Sepsis - immunology
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