Altered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation

•A non-human primate model of maternal immune activation (MIA) and neurodevelopment.•Offspring previously shown to have reduced frontal volumes and cognitive impairments.•Here, prefrontal n-acetylaspartate (NAA) is elevated across childhood and adolescence.•Elevated NAA correlates with less impaired...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2024-10, Vol.121, p.280-290
Hauptverfasser:	Maddock, Richard J., Vlasova, Roza M., Chen, Shuai, Iosif, Ana-Maria, Bennett, Jeffrey, Tanase, Costin, Ryan, Amy M., Murai, Takeshi, Hogrefe, Casey E., Schumann, Cynthia D., Geschwind, Daniel H., Van de Water, Judy, Amaral, David G., Lesh, Tyler A., Styner, Martin A., Kimberley McAllister, A., Carter, Cameron S., Bauman, Melissa D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Animals Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Brain - metabolism Childhood Choline - metabolism Creatine - metabolism Disease Models, Animal Female Gestational immune activation Glutamic Acid - metabolism Glutathione - metabolism Inositol - metabolism Longitudinal Studies Macaca mulatta Macaque Magnetic resonance spectroscopy Male Myo-inositol N-acetylaspartate Poly I-C - pharmacology Prefrontal Prefrontal Cortex - metabolism Pregnancy Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - metabolism Resilience Taurine - metabolism
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