Novel peptides derived from S. hispanica seeds induce selective cytotoxicity on human cancer cells
Cancer prevails as one of the major health concerns worldwide due to the consistent rise in incidence and lack of effective therapies. Previous studies identified the peptides KLKKNL, MLKSKR, and KKYRVF from Salvia hispanica seeds and stated their selective anticancer activity. Thus, this study aime...
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| Veröffentlicht in: | Food chemistry 2024-12, Vol.460 (Pt 1), p.140470, Article 140470 |
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| creator | Quintal Bojórquez, Nidia del Carmen Segura Campos, Maira Rubi |
| description | Cancer prevails as one of the major health concerns worldwide due to the consistent rise in incidence and lack of effective therapies. Previous studies identified the peptides KLKKNL, MLKSKR, and KKYRVF from Salvia hispanica seeds and stated their selective anticancer activity. Thus, this study aimed to determine the cell death pathway induced by these peptides on five cancer cell lines (MCF-7, Caco2, HepG2, DU145, and HeLa). Based on the results of this work, it is possible to suggest that KLKKNL primarily induces selective cancer cell death through the apoptotic pathway in the Caco2 and HeLa lines. On the other hand, the peptide KKYRVF reported the highest statistical (p |
| doi_str_mv | 10.1016/j.foodchem.2024.140470 |
| format | Article |
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[Display omitted]
•Cancer is one of the major health concerns worldwide with increasing incidence.•Anticancer peptides are promising therapeutic option due to specificity and efficacy.•KLKKNL, MLKSKR and KKYRVF identified from S. hispanica report anticancer properties.•KLKKNL primarily induces the apoptotic pathway in the Caco2 and HeLa cancer lines.•KKYRVF induces the necrotic pathway in the MCF-7, Caco2, HepG2 and DU145 lines.</description><identifier>ISSN: 0308-8146</identifier><identifier>ISSN: 1873-7072</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2024.140470</identifier><identifier>PMID: 39032303</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anticancer peptides ; Anticancer therapy ; antineoplastic activity ; apoptosis ; Bioactive compounds ; Cytotoxicity ; food chemistry ; humans ; neoplasm cells ; Nutraceuticals ; peptides ; Salvia hispanica</subject><ispartof>Food chemistry, 2024-12, Vol.460 (Pt 1), p.140470, Article 140470</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c278t-cc1f284507b05a6529dd5956e29907b359212746dfdf02a8233cf631edfcefe73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0308814624021204$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39032303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quintal Bojórquez, Nidia del Carmen</creatorcontrib><creatorcontrib>Segura Campos, Maira Rubi</creatorcontrib><title>Novel peptides derived from S. hispanica seeds induce selective cytotoxicity on human cancer cells</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>Cancer prevails as one of the major health concerns worldwide due to the consistent rise in incidence and lack of effective therapies. Previous studies identified the peptides KLKKNL, MLKSKR, and KKYRVF from Salvia hispanica seeds and stated their selective anticancer activity. Thus, this study aimed to determine the cell death pathway induced by these peptides on five cancer cell lines (MCF-7, Caco2, HepG2, DU145, and HeLa). Based on the results of this work, it is possible to suggest that KLKKNL primarily induces selective cancer cell death through the apoptotic pathway in the Caco2 and HeLa lines. On the other hand, the peptide KKYRVF reported the highest statistical (p < 0.05) selective cytotoxic effect on the MCF-7, Caco2, HepG2, and DU145 cancer cell lines by induction of the necrotic pathway. These findings offer some understanding of the selective anticancer effect of KLKKNL, MLKSKR, and KKYRVF.
[Display omitted]
•Cancer is one of the major health concerns worldwide with increasing incidence.•Anticancer peptides are promising therapeutic option due to specificity and efficacy.•KLKKNL, MLKSKR and KKYRVF identified from S. hispanica report anticancer properties.•KLKKNL primarily induces the apoptotic pathway in the Caco2 and HeLa cancer lines.•KKYRVF induces the necrotic pathway in the MCF-7, Caco2, HepG2 and DU145 lines.</description><subject>Anticancer peptides</subject><subject>Anticancer therapy</subject><subject>antineoplastic activity</subject><subject>apoptosis</subject><subject>Bioactive compounds</subject><subject>Cytotoxicity</subject><subject>food chemistry</subject><subject>humans</subject><subject>neoplasm cells</subject><subject>Nutraceuticals</subject><subject>peptides</subject><subject>Salvia hispanica</subject><issn>0308-8146</issn><issn>1873-7072</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkUFv1DAQhS1ERZeFv1D5yCVhbCexcwNVtEWq4ACcLa891nqVxMFOVuy_r1fbcu1pNKPvzYzeI-SGQc2AdZ8PtY_R2T2ONQfe1KyBRsIbsmFKikqC5G_JBgSoSrGmuybvcz4AAAem3pFr0YPgAsSG7H7EIw50xnkJDjN1mMIRHfUpjvRXTfchz2YK1tCM6DINk1stlmZAuxSS2tMSl_gv2LCcaJzofh3NRK2ZLCZqcRjyB3LlzZDx43Pdkj93337fPlSPP--_3359rCyXaqmsZZ6rpgW5g9Z0Le-da_u2Q973ZSbanjMum85554EbxYWwvhMMnbfoUYot-XTZO6f4d8W86DHk8wdmwrhmLVgrpFR9K15HQQnOWiiKLekuqE0x54RezymMJp00A32OQh_0SxT6HIW-RFGEN8831t2I7r_sxfsCfLkAWEw5Bkw624DFNxdSMVe7GF678QStFJ2c</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Quintal Bojórquez, Nidia del Carmen</creator><creator>Segura Campos, Maira Rubi</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20241201</creationdate><title>Novel peptides derived from S. hispanica seeds induce selective cytotoxicity on human cancer cells</title><author>Quintal Bojórquez, Nidia del Carmen ; Segura Campos, Maira Rubi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-cc1f284507b05a6529dd5956e29907b359212746dfdf02a8233cf631edfcefe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anticancer peptides</topic><topic>Anticancer therapy</topic><topic>antineoplastic activity</topic><topic>apoptosis</topic><topic>Bioactive compounds</topic><topic>Cytotoxicity</topic><topic>food chemistry</topic><topic>humans</topic><topic>neoplasm cells</topic><topic>Nutraceuticals</topic><topic>peptides</topic><topic>Salvia hispanica</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quintal Bojórquez, Nidia del Carmen</creatorcontrib><creatorcontrib>Segura Campos, Maira Rubi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quintal Bojórquez, Nidia del Carmen</au><au>Segura Campos, Maira Rubi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel peptides derived from S. hispanica seeds induce selective cytotoxicity on human cancer cells</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>460</volume><issue>Pt 1</issue><spage>140470</spage><pages>140470-</pages><artnum>140470</artnum><issn>0308-8146</issn><issn>1873-7072</issn><eissn>1873-7072</eissn><abstract>Cancer prevails as one of the major health concerns worldwide due to the consistent rise in incidence and lack of effective therapies. Previous studies identified the peptides KLKKNL, MLKSKR, and KKYRVF from Salvia hispanica seeds and stated their selective anticancer activity. Thus, this study aimed to determine the cell death pathway induced by these peptides on five cancer cell lines (MCF-7, Caco2, HepG2, DU145, and HeLa). Based on the results of this work, it is possible to suggest that KLKKNL primarily induces selective cancer cell death through the apoptotic pathway in the Caco2 and HeLa lines. On the other hand, the peptide KKYRVF reported the highest statistical (p < 0.05) selective cytotoxic effect on the MCF-7, Caco2, HepG2, and DU145 cancer cell lines by induction of the necrotic pathway. These findings offer some understanding of the selective anticancer effect of KLKKNL, MLKSKR, and KKYRVF.
[Display omitted]
•Cancer is one of the major health concerns worldwide with increasing incidence.•Anticancer peptides are promising therapeutic option due to specificity and efficacy.•KLKKNL, MLKSKR and KKYRVF identified from S. hispanica report anticancer properties.•KLKKNL primarily induces the apoptotic pathway in the Caco2 and HeLa cancer lines.•KKYRVF induces the necrotic pathway in the MCF-7, Caco2, HepG2 and DU145 lines.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39032303</pmid><doi>10.1016/j.foodchem.2024.140470</doi></addata></record> |
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| issn | 0308-8146 1873-7072 1873-7072 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Anticancer peptides Anticancer therapy antineoplastic activity apoptosis Bioactive compounds Cytotoxicity food chemistry humans neoplasm cells Nutraceuticals peptides Salvia hispanica |
| title | Novel peptides derived from S. hispanica seeds induce selective cytotoxicity on human cancer cells |
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