SPECT myocardial perfusion imaging for the evaluation of left ventricular mechanical dyssynchrony in obese patients
Objective Left ventricular dyssynchrony (LVD), the loss of coordinated contraction in the left ventricle, is an early sign of heart failure. LVD can be assessed using phase analysis techniques with gated single‐photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). This stud...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical ultrasound 2024-10, Vol.52 (8), p.1037-1043 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1043 |
|---|---|
| container_issue | 8 |
| container_start_page | 1037 |
| container_title | Journal of clinical ultrasound |
| container_volume | 52 |
| creator | Caliskan, Billur Inanir, Mehmet |
| description | Objective
Left ventricular dyssynchrony (LVD), the loss of coordinated contraction in the left ventricle, is an early sign of heart failure. LVD can be assessed using phase analysis techniques with gated single‐photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). This study aimed to investigate the impact of obesity on LVD through phase analysis.
Methods
We retrospectively enrolled 152 obese patients and 80 age‐ and sex‐matched nonobese patients who showed normal myocardial perfusion and normal left ventricular ejection fraction (LVEF) on MPI. Phase standard deviation (PSD) and phase histogram bandwidth (PBW), as phase analysis parameters, were compared between patients with and without obesity.
Results
Although PSD values were within the normal range (cut‐off value >23) for both groups, the PSD values of obese patients were higher than those of the nonobese (20.49 ± 8.66 vs. 14.81 ± 4.93; p |
| doi_str_mv | 10.1002/jcu.23752 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3082959160</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3082959160</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2432-c3974ef88aafdc301a49250f5858db589dbbbb5780d4991b07c290b6ddf2d7d03</originalsourceid><addsrcrecordid>eNp10U1L7DAUBuAgV3T8WPgHLoG70UX1JJlMm6UMfiIoqOuQ5sPJ0DZj0ir992YcvQvBbM4iT17CeRE6InBKAOjZUg-nlJWcbqEJAVEWAGL2B03yIAUtOdlFeyktAWDGOd9Bu0wAI5yLCUqPDxfzJ9yOQatovGrwykY3JB867Fv14rsX7ELE_cJi-6aaQfXrq-BwY12P32zXR6-HRkXcWr1Qndc5w4wpjZ1exNCN2Gde22TxKr_NPh2gbaeaZA-_5j56vrx4ml8Xd_dXN_Pzu0LTKaOFZqKcWldVSjmjGRA1FZSD4xWvTM0rYep8eFmBmQpBaig1FVDPjHHUlAbYPjre5K5ieB1s6mXrk7ZNozobhiQZVFRwQWZr-u8HXYYhdvl3khHCgBLBRFYnG6VjSClaJ1cxLymOkoBcNyFzE_KziWz_fiUOdWvNf_m9-gzONuDdN3b8PUnezp83kR9flpO3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3113021939</pqid></control><display><type>article</type><title>SPECT myocardial perfusion imaging for the evaluation of left ventricular mechanical dyssynchrony in obese patients</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Caliskan, Billur ; Inanir, Mehmet</creator><creatorcontrib>Caliskan, Billur ; Inanir, Mehmet</creatorcontrib><description>Objective
Left ventricular dyssynchrony (LVD), the loss of coordinated contraction in the left ventricle, is an early sign of heart failure. LVD can be assessed using phase analysis techniques with gated single‐photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). This study aimed to investigate the impact of obesity on LVD through phase analysis.
Methods
We retrospectively enrolled 152 obese patients and 80 age‐ and sex‐matched nonobese patients who showed normal myocardial perfusion and normal left ventricular ejection fraction (LVEF) on MPI. Phase standard deviation (PSD) and phase histogram bandwidth (PBW), as phase analysis parameters, were compared between patients with and without obesity.
Results
Although PSD values were within the normal range (cut‐off value >23) for both groups, the PSD values of obese patients were higher than those of the nonobese (20.49 ± 8.66 vs. 14.81 ± 4.93; p < 0.05). PBW values of obese patients were statistically significantly higher than those of the nonobese (57.03 ± 23.17 vs. 41.40 ± 9.96; p < 0.05). The PBW values of obese patients exceeded the normal limits (cut‐off value >49). A weak positive correlation was observed between body mass index (BMI) and PBW values in obese patients (r = 0.181, p < 0.05). In patients of normal weight, no correlations were found between BMI and phase analysis parameters.
Conclusion
LVD may develop in obese patients, even when myocardial perfusion and ejection fraction are preserved. The use of phase analysis with gated SPECT could be an additional finding improving the early detection of left ventricular dyssynchrony in obese patients.
In our study, we found that the phase analysis parameters, indicative of left ventricular dyssynchrony, were higher in obese patients compared with normal‐weight individuals, even when myocardial perfusion and ejection fraction are preserved. The use of phase analysis with gated SPECT is beneficial for the early detection of LVD in obese patients.</description><identifier>ISSN: 0091-2751</identifier><identifier>ISSN: 1097-0096</identifier><identifier>EISSN: 1097-0096</identifier><identifier>DOI: 10.1002/jcu.23752</identifier><identifier>PMID: 39031559</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aged ; Body mass index ; Body size ; Computed tomography ; Congestive heart failure ; Ejection fraction ; Emission analysis ; Failure analysis ; Female ; gated SPECT ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; Impact analysis ; left ventricular dyssynchrony ; Male ; Medical imaging ; Middle Aged ; Myocardial Perfusion Imaging - methods ; Obesity ; Obesity - complications ; Obesity - physiopathology ; Parameters ; Perfusion ; phase analysis ; Photon emission ; Retrospective Studies ; Single photon emission computed tomography ; Tomography, Emission-Computed, Single-Photon - methods ; Ventricle ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Journal of clinical ultrasound, 2024-10, Vol.52 (8), p.1037-1043</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2432-c3974ef88aafdc301a49250f5858db589dbbbb5780d4991b07c290b6ddf2d7d03</cites><orcidid>0000-0003-1719-5994</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcu.23752$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcu.23752$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39031559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caliskan, Billur</creatorcontrib><creatorcontrib>Inanir, Mehmet</creatorcontrib><title>SPECT myocardial perfusion imaging for the evaluation of left ventricular mechanical dyssynchrony in obese patients</title><title>Journal of clinical ultrasound</title><addtitle>J Clin Ultrasound</addtitle><description>Objective
Left ventricular dyssynchrony (LVD), the loss of coordinated contraction in the left ventricle, is an early sign of heart failure. LVD can be assessed using phase analysis techniques with gated single‐photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). This study aimed to investigate the impact of obesity on LVD through phase analysis.
Methods
We retrospectively enrolled 152 obese patients and 80 age‐ and sex‐matched nonobese patients who showed normal myocardial perfusion and normal left ventricular ejection fraction (LVEF) on MPI. Phase standard deviation (PSD) and phase histogram bandwidth (PBW), as phase analysis parameters, were compared between patients with and without obesity.
Results
Although PSD values were within the normal range (cut‐off value >23) for both groups, the PSD values of obese patients were higher than those of the nonobese (20.49 ± 8.66 vs. 14.81 ± 4.93; p < 0.05). PBW values of obese patients were statistically significantly higher than those of the nonobese (57.03 ± 23.17 vs. 41.40 ± 9.96; p < 0.05). The PBW values of obese patients exceeded the normal limits (cut‐off value >49). A weak positive correlation was observed between body mass index (BMI) and PBW values in obese patients (r = 0.181, p < 0.05). In patients of normal weight, no correlations were found between BMI and phase analysis parameters.
Conclusion
LVD may develop in obese patients, even when myocardial perfusion and ejection fraction are preserved. The use of phase analysis with gated SPECT could be an additional finding improving the early detection of left ventricular dyssynchrony in obese patients.
In our study, we found that the phase analysis parameters, indicative of left ventricular dyssynchrony, were higher in obese patients compared with normal‐weight individuals, even when myocardial perfusion and ejection fraction are preserved. The use of phase analysis with gated SPECT is beneficial for the early detection of LVD in obese patients.</description><subject>Aged</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Computed tomography</subject><subject>Congestive heart failure</subject><subject>Ejection fraction</subject><subject>Emission analysis</subject><subject>Failure analysis</subject><subject>Female</subject><subject>gated SPECT</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Impact analysis</subject><subject>left ventricular dyssynchrony</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Parameters</subject><subject>Perfusion</subject><subject>phase analysis</subject><subject>Photon emission</subject><subject>Retrospective Studies</subject><subject>Single photon emission computed tomography</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0091-2751</issn><issn>1097-0096</issn><issn>1097-0096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1L7DAUBuAgV3T8WPgHLoG70UX1JJlMm6UMfiIoqOuQ5sPJ0DZj0ir992YcvQvBbM4iT17CeRE6InBKAOjZUg-nlJWcbqEJAVEWAGL2B03yIAUtOdlFeyktAWDGOd9Bu0wAI5yLCUqPDxfzJ9yOQatovGrwykY3JB867Fv14rsX7ELE_cJi-6aaQfXrq-BwY12P32zXR6-HRkXcWr1Qndc5w4wpjZ1exNCN2Gde22TxKr_NPh2gbaeaZA-_5j56vrx4ml8Xd_dXN_Pzu0LTKaOFZqKcWldVSjmjGRA1FZSD4xWvTM0rYep8eFmBmQpBaig1FVDPjHHUlAbYPjre5K5ieB1s6mXrk7ZNozobhiQZVFRwQWZr-u8HXYYhdvl3khHCgBLBRFYnG6VjSClaJ1cxLymOkoBcNyFzE_KziWz_fiUOdWvNf_m9-gzONuDdN3b8PUnezp83kR9flpO3</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Caliskan, Billur</creator><creator>Inanir, Mehmet</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1719-5994</orcidid></search><sort><creationdate>202410</creationdate><title>SPECT myocardial perfusion imaging for the evaluation of left ventricular mechanical dyssynchrony in obese patients</title><author>Caliskan, Billur ; Inanir, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2432-c3974ef88aafdc301a49250f5858db589dbbbb5780d4991b07c290b6ddf2d7d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Computed tomography</topic><topic>Congestive heart failure</topic><topic>Ejection fraction</topic><topic>Emission analysis</topic><topic>Failure analysis</topic><topic>Female</topic><topic>gated SPECT</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Impact analysis</topic><topic>left ventricular dyssynchrony</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Parameters</topic><topic>Perfusion</topic><topic>phase analysis</topic><topic>Photon emission</topic><topic>Retrospective Studies</topic><topic>Single photon emission computed tomography</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caliskan, Billur</creatorcontrib><creatorcontrib>Inanir, Mehmet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caliskan, Billur</au><au>Inanir, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SPECT myocardial perfusion imaging for the evaluation of left ventricular mechanical dyssynchrony in obese patients</atitle><jtitle>Journal of clinical ultrasound</jtitle><addtitle>J Clin Ultrasound</addtitle><date>2024-10</date><risdate>2024</risdate><volume>52</volume><issue>8</issue><spage>1037</spage><epage>1043</epage><pages>1037-1043</pages><issn>0091-2751</issn><issn>1097-0096</issn><eissn>1097-0096</eissn><abstract>Objective
Left ventricular dyssynchrony (LVD), the loss of coordinated contraction in the left ventricle, is an early sign of heart failure. LVD can be assessed using phase analysis techniques with gated single‐photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). This study aimed to investigate the impact of obesity on LVD through phase analysis.
Methods
We retrospectively enrolled 152 obese patients and 80 age‐ and sex‐matched nonobese patients who showed normal myocardial perfusion and normal left ventricular ejection fraction (LVEF) on MPI. Phase standard deviation (PSD) and phase histogram bandwidth (PBW), as phase analysis parameters, were compared between patients with and without obesity.
Results
Although PSD values were within the normal range (cut‐off value >23) for both groups, the PSD values of obese patients were higher than those of the nonobese (20.49 ± 8.66 vs. 14.81 ± 4.93; p < 0.05). PBW values of obese patients were statistically significantly higher than those of the nonobese (57.03 ± 23.17 vs. 41.40 ± 9.96; p < 0.05). The PBW values of obese patients exceeded the normal limits (cut‐off value >49). A weak positive correlation was observed between body mass index (BMI) and PBW values in obese patients (r = 0.181, p < 0.05). In patients of normal weight, no correlations were found between BMI and phase analysis parameters.
Conclusion
LVD may develop in obese patients, even when myocardial perfusion and ejection fraction are preserved. The use of phase analysis with gated SPECT could be an additional finding improving the early detection of left ventricular dyssynchrony in obese patients.
In our study, we found that the phase analysis parameters, indicative of left ventricular dyssynchrony, were higher in obese patients compared with normal‐weight individuals, even when myocardial perfusion and ejection fraction are preserved. The use of phase analysis with gated SPECT is beneficial for the early detection of LVD in obese patients.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>39031559</pmid><doi>10.1002/jcu.23752</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1719-5994</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-2751 |
| ispartof | Journal of clinical ultrasound, 2024-10, Vol.52 (8), p.1037-1043 |
| issn | 0091-2751 1097-0096 1097-0096 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3082959160 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aged Body mass index Body size Computed tomography Congestive heart failure Ejection fraction Emission analysis Failure analysis Female gated SPECT Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Impact analysis left ventricular dyssynchrony Male Medical imaging Middle Aged Myocardial Perfusion Imaging - methods Obesity Obesity - complications Obesity - physiopathology Parameters Perfusion phase analysis Photon emission Retrospective Studies Single photon emission computed tomography Tomography, Emission-Computed, Single-Photon - methods Ventricle Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | SPECT myocardial perfusion imaging for the evaluation of left ventricular mechanical dyssynchrony in obese patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T06%3A14%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SPECT%20myocardial%20perfusion%20imaging%20for%20the%20evaluation%20of%20left%20ventricular%20mechanical%20dyssynchrony%20in%20obese%20patients&rft.jtitle=Journal%20of%20clinical%20ultrasound&rft.au=Caliskan,%20Billur&rft.date=2024-10&rft.volume=52&rft.issue=8&rft.spage=1037&rft.epage=1043&rft.pages=1037-1043&rft.issn=0091-2751&rft.eissn=1097-0096&rft_id=info:doi/10.1002/jcu.23752&rft_dat=%3Cproquest_cross%3E3082959160%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3113021939&rft_id=info:pmid/39031559&rfr_iscdi=true |