Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, and miR‐548a‐3p as Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation
ABSTRACT Background There are currently no laboratory tests that can accurately predict the likelihood of developing acute graft‐versus‐host disease (aGVHD), a patient's response to treatment, or their survival chance. This research aimed to establish circulating miRNAs as diagnostic, prognosti...
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| Veröffentlicht in: | Clinical transplantation 2024-06, Vol.38 (6), p.e15371-n/a |
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| creator | Izadifard, Marzieh Ahmadvand, Mohammad Pashaiefar, Hossein Alimoghadam, Kamran Kasaeian, Amir Barkhordar, Maryam Seghatoleslami, Ghazal Vaezi, Mohammad Ghavamzadeh, Ardeshir Yaghmaie, Marjan |
| description | ABSTRACT
Background
There are currently no laboratory tests that can accurately predict the likelihood of developing acute graft‐versus‐host disease (aGVHD), a patient's response to treatment, or their survival chance. This research aimed to establish circulating miRNAs as diagnostic, prognostic, or predictive biomarkers of aGVHD.
Methods
In a prospective cohort, we studied the incidence of cutaneous aGVHD in AML patients undergoing allo‐HSCT at Shariati Hospital in Tehran, Iran during 2020–2023. Patients with cutaneous aGVHD were labeled as the case group, while patients without cutaneous aGVHD were selected as the control group. Accordingly, the expression levels of six significant miRNAs (miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, miR‐548a‐3p) were evaluated by quantitative reverse transcription–polymerase chain reaction (RTqPCR) in three different time‐points: before transplantation, on day 14 and day 21 after transplantation.
Results
The levels of plasma miR‐455‐3p, miR‐5787, miR‐638, and miR‐3613‐5p were significantly downregulated, while miR‐548a‐3p, and miR‐6511b‐5p were significantly upregulated in individuals with cutaneous aGVHD in comparison to patients without GVHD. Additionally, the possibility for great diagnostic accuracy for cutaneous aGVHD was revealed by ROC curve analysis of differentially expressed miRNAs (DEMs).
Conclusion
The study findings encourage us to hypothesize that the aforementioned miRNAs may contribute to the predominance of aGVHD, particularly low‐grade cutaneous aGVHD. |
| doi_str_mv | 10.1111/ctr.15371 |
| format | Article |
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Background
There are currently no laboratory tests that can accurately predict the likelihood of developing acute graft‐versus‐host disease (aGVHD), a patient's response to treatment, or their survival chance. This research aimed to establish circulating miRNAs as diagnostic, prognostic, or predictive biomarkers of aGVHD.
Methods
In a prospective cohort, we studied the incidence of cutaneous aGVHD in AML patients undergoing allo‐HSCT at Shariati Hospital in Tehran, Iran during 2020–2023. Patients with cutaneous aGVHD were labeled as the case group, while patients without cutaneous aGVHD were selected as the control group. Accordingly, the expression levels of six significant miRNAs (miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, miR‐548a‐3p) were evaluated by quantitative reverse transcription–polymerase chain reaction (RTqPCR) in three different time‐points: before transplantation, on day 14 and day 21 after transplantation.
Results
The levels of plasma miR‐455‐3p, miR‐5787, miR‐638, and miR‐3613‐5p were significantly downregulated, while miR‐548a‐3p, and miR‐6511b‐5p were significantly upregulated in individuals with cutaneous aGVHD in comparison to patients without GVHD. Additionally, the possibility for great diagnostic accuracy for cutaneous aGVHD was revealed by ROC curve analysis of differentially expressed miRNAs (DEMs).
Conclusion
The study findings encourage us to hypothesize that the aforementioned miRNAs may contribute to the predominance of aGVHD, particularly low‐grade cutaneous aGVHD.</description><identifier>ISSN: 0902-0063</identifier><identifier>ISSN: 1399-0012</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/ctr.15371</identifier><identifier>PMID: 39031894</identifier><language>eng</language><publisher>Denmark</publisher><subject>acute myeloid leukemia ; Adolescent ; Adult ; Biomarkers - blood ; Case-Control Studies ; circulating miRNAs ; cutaneous aGVHD ; diagnostic ; Female ; Follow-Up Studies ; Graft vs Host Disease - blood ; Graft vs Host Disease - diagnosis ; Graft vs Host Disease - etiology ; hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Leukemia, Myeloid, Acute - blood ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - therapy ; Male ; MicroRNAs - blood ; MicroRNAs - genetics ; Middle Aged ; non‐invasive biomarkers ; Prognosis ; Prospective Studies ; Skin Diseases - blood ; Skin Diseases - diagnosis ; Skin Diseases - etiology ; Transplantation, Homologous ; Young Adult</subject><ispartof>Clinical transplantation, 2024-06, Vol.38 (6), p.e15371-n/a</ispartof><rights>2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2151-2108fd91a41d0dbc5ad5aca9810ac5f5c3142da8931805ed8f8e3b27498222513</cites><orcidid>0000-0002-8121-2819 ; 0000-0002-3186-5491 ; 0000-0001-5587-0191 ; 0000-0002-3965-0460 ; 0009-0005-4058-1094 ; 0000-0001-7745-9360 ; 0000-0002-3849-6545 ; 0009-0006-3014-3776 ; 0000-0003-0673-4841 ; 0000-0003-2018-9368</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fctr.15371$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fctr.15371$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39031894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izadifard, Marzieh</creatorcontrib><creatorcontrib>Ahmadvand, Mohammad</creatorcontrib><creatorcontrib>Pashaiefar, Hossein</creatorcontrib><creatorcontrib>Alimoghadam, Kamran</creatorcontrib><creatorcontrib>Kasaeian, Amir</creatorcontrib><creatorcontrib>Barkhordar, Maryam</creatorcontrib><creatorcontrib>Seghatoleslami, Ghazal</creatorcontrib><creatorcontrib>Vaezi, Mohammad</creatorcontrib><creatorcontrib>Ghavamzadeh, Ardeshir</creatorcontrib><creatorcontrib>Yaghmaie, Marjan</creatorcontrib><title>Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, and miR‐548a‐3p as Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>ABSTRACT
Background
There are currently no laboratory tests that can accurately predict the likelihood of developing acute graft‐versus‐host disease (aGVHD), a patient's response to treatment, or their survival chance. This research aimed to establish circulating miRNAs as diagnostic, prognostic, or predictive biomarkers of aGVHD.
Methods
In a prospective cohort, we studied the incidence of cutaneous aGVHD in AML patients undergoing allo‐HSCT at Shariati Hospital in Tehran, Iran during 2020–2023. Patients with cutaneous aGVHD were labeled as the case group, while patients without cutaneous aGVHD were selected as the control group. Accordingly, the expression levels of six significant miRNAs (miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, miR‐548a‐3p) were evaluated by quantitative reverse transcription–polymerase chain reaction (RTqPCR) in three different time‐points: before transplantation, on day 14 and day 21 after transplantation.
Results
The levels of plasma miR‐455‐3p, miR‐5787, miR‐638, and miR‐3613‐5p were significantly downregulated, while miR‐548a‐3p, and miR‐6511b‐5p were significantly upregulated in individuals with cutaneous aGVHD in comparison to patients without GVHD. Additionally, the possibility for great diagnostic accuracy for cutaneous aGVHD was revealed by ROC curve analysis of differentially expressed miRNAs (DEMs).
Conclusion
The study findings encourage us to hypothesize that the aforementioned miRNAs may contribute to the predominance of aGVHD, particularly low‐grade cutaneous aGVHD.</description><subject>acute myeloid leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>circulating miRNAs</subject><subject>cutaneous aGVHD</subject><subject>diagnostic</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft vs Host Disease - blood</subject><subject>Graft vs Host Disease - diagnosis</subject><subject>Graft vs Host Disease - etiology</subject><subject>hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - blood</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Male</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>non‐invasive biomarkers</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Skin Diseases - blood</subject><subject>Skin Diseases - diagnosis</subject><subject>Skin Diseases - etiology</subject><subject>Transplantation, Homologous</subject><subject>Young Adult</subject><issn>0902-0063</issn><issn>1399-0012</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Uk1v1DAQDQhEl8KBC0fkI0jd1h9x1j4uKe0iVVCVhWs06zhbQ2KnttOqt_6E9i_2l-BtupU44Mu8eXp6euOZLHtH8D5J70BFv084m5Hn2YQwKacYE_oim2CJacIF28leh_A7sQUp-Ktsh0nMiJD55Nn7QwNr64IJyDWoHCJY7YaA5mqIGh17aOL9zd0v7cMQEli4ENGhCRqCRstz74b1OSqNV0ML0dg1Om0hdIA6c3Z_c1swsbeFnJBVqrzfMqwg7B8i53xDP_V8JmZ7CGy97XMBDwIEAZ16F3qtornU6Juzxl5C2ODPxnXg_6S86Mi1rbvahJonsNZWG4UWuoPoemd0TN2PqDtU6rZFSw829C3YmOZw9k32soE26LePdTf7efRlWS6mJ9-Pv5bzk6mihJMpJVg0tSSQkxrXK8Wh5qBACoJB8YYrRnJag5DptzHXtWiEZis6y6WglHLCdrOPo2_v3cWgQ6w6E1QKNK6hYlhQyZOdSNJPo1Sl0YPXTdV7k2a9rgiuNmdQpTOoHs4gaT882g6rTtdPyu3ek-BgFFyZVl__36kql2ej5V-gkseV</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Izadifard, Marzieh</creator><creator>Ahmadvand, Mohammad</creator><creator>Pashaiefar, Hossein</creator><creator>Alimoghadam, Kamran</creator><creator>Kasaeian, Amir</creator><creator>Barkhordar, Maryam</creator><creator>Seghatoleslami, Ghazal</creator><creator>Vaezi, Mohammad</creator><creator>Ghavamzadeh, Ardeshir</creator><creator>Yaghmaie, Marjan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8121-2819</orcidid><orcidid>https://orcid.org/0000-0002-3186-5491</orcidid><orcidid>https://orcid.org/0000-0001-5587-0191</orcidid><orcidid>https://orcid.org/0000-0002-3965-0460</orcidid><orcidid>https://orcid.org/0009-0005-4058-1094</orcidid><orcidid>https://orcid.org/0000-0001-7745-9360</orcidid><orcidid>https://orcid.org/0000-0002-3849-6545</orcidid><orcidid>https://orcid.org/0009-0006-3014-3776</orcidid><orcidid>https://orcid.org/0000-0003-0673-4841</orcidid><orcidid>https://orcid.org/0000-0003-2018-9368</orcidid></search><sort><creationdate>202406</creationdate><title>Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, and miR‐548a‐3p as Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation</title><author>Izadifard, Marzieh ; Ahmadvand, Mohammad ; Pashaiefar, Hossein ; Alimoghadam, Kamran ; Kasaeian, Amir ; Barkhordar, Maryam ; Seghatoleslami, Ghazal ; Vaezi, Mohammad ; Ghavamzadeh, Ardeshir ; Yaghmaie, Marjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2151-2108fd91a41d0dbc5ad5aca9810ac5f5c3142da8931805ed8f8e3b27498222513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>acute myeloid leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>circulating miRNAs</topic><topic>cutaneous aGVHD</topic><topic>diagnostic</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft vs Host Disease - blood</topic><topic>Graft vs Host Disease - diagnosis</topic><topic>Graft vs Host Disease - etiology</topic><topic>hematopoietic stem cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - blood</topic><topic>Leukemia, Myeloid, Acute - diagnosis</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Male</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>non‐invasive biomarkers</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Skin Diseases - blood</topic><topic>Skin Diseases - diagnosis</topic><topic>Skin Diseases - etiology</topic><topic>Transplantation, Homologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Izadifard, Marzieh</creatorcontrib><creatorcontrib>Ahmadvand, Mohammad</creatorcontrib><creatorcontrib>Pashaiefar, Hossein</creatorcontrib><creatorcontrib>Alimoghadam, Kamran</creatorcontrib><creatorcontrib>Kasaeian, Amir</creatorcontrib><creatorcontrib>Barkhordar, Maryam</creatorcontrib><creatorcontrib>Seghatoleslami, Ghazal</creatorcontrib><creatorcontrib>Vaezi, Mohammad</creatorcontrib><creatorcontrib>Ghavamzadeh, Ardeshir</creatorcontrib><creatorcontrib>Yaghmaie, Marjan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izadifard, Marzieh</au><au>Ahmadvand, Mohammad</au><au>Pashaiefar, Hossein</au><au>Alimoghadam, Kamran</au><au>Kasaeian, Amir</au><au>Barkhordar, Maryam</au><au>Seghatoleslami, Ghazal</au><au>Vaezi, Mohammad</au><au>Ghavamzadeh, Ardeshir</au><au>Yaghmaie, Marjan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, and miR‐548a‐3p as Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2024-06</date><risdate>2024</risdate><volume>38</volume><issue>6</issue><spage>e15371</spage><epage>n/a</epage><pages>e15371-n/a</pages><issn>0902-0063</issn><issn>1399-0012</issn><eissn>1399-0012</eissn><abstract>ABSTRACT
Background
There are currently no laboratory tests that can accurately predict the likelihood of developing acute graft‐versus‐host disease (aGVHD), a patient's response to treatment, or their survival chance. This research aimed to establish circulating miRNAs as diagnostic, prognostic, or predictive biomarkers of aGVHD.
Methods
In a prospective cohort, we studied the incidence of cutaneous aGVHD in AML patients undergoing allo‐HSCT at Shariati Hospital in Tehran, Iran during 2020–2023. Patients with cutaneous aGVHD were labeled as the case group, while patients without cutaneous aGVHD were selected as the control group. Accordingly, the expression levels of six significant miRNAs (miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, miR‐548a‐3p) were evaluated by quantitative reverse transcription–polymerase chain reaction (RTqPCR) in three different time‐points: before transplantation, on day 14 and day 21 after transplantation.
Results
The levels of plasma miR‐455‐3p, miR‐5787, miR‐638, and miR‐3613‐5p were significantly downregulated, while miR‐548a‐3p, and miR‐6511b‐5p were significantly upregulated in individuals with cutaneous aGVHD in comparison to patients without GVHD. Additionally, the possibility for great diagnostic accuracy for cutaneous aGVHD was revealed by ROC curve analysis of differentially expressed miRNAs (DEMs).
Conclusion
The study findings encourage us to hypothesize that the aforementioned miRNAs may contribute to the predominance of aGVHD, particularly low‐grade cutaneous aGVHD.</abstract><cop>Denmark</cop><pmid>39031894</pmid><doi>10.1111/ctr.15371</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8121-2819</orcidid><orcidid>https://orcid.org/0000-0002-3186-5491</orcidid><orcidid>https://orcid.org/0000-0001-5587-0191</orcidid><orcidid>https://orcid.org/0000-0002-3965-0460</orcidid><orcidid>https://orcid.org/0009-0005-4058-1094</orcidid><orcidid>https://orcid.org/0000-0001-7745-9360</orcidid><orcidid>https://orcid.org/0000-0002-3849-6545</orcidid><orcidid>https://orcid.org/0009-0006-3014-3776</orcidid><orcidid>https://orcid.org/0000-0003-0673-4841</orcidid><orcidid>https://orcid.org/0000-0003-2018-9368</orcidid></addata></record> |
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| ispartof | Clinical transplantation, 2024-06, Vol.38 (6), p.e15371-n/a |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acute myeloid leukemia Adolescent Adult Biomarkers - blood Case-Control Studies circulating miRNAs cutaneous aGVHD diagnostic Female Follow-Up Studies Graft vs Host Disease - blood Graft vs Host Disease - diagnosis Graft vs Host Disease - etiology hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Humans Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - therapy Male MicroRNAs - blood MicroRNAs - genetics Middle Aged non‐invasive biomarkers Prognosis Prospective Studies Skin Diseases - blood Skin Diseases - diagnosis Skin Diseases - etiology Transplantation, Homologous Young Adult |
| title | Diagnosis of Cutaneous Acute Graft‑Versus‑Host Disease Through Circulating Plasma miR‐638, miR‐6511b‐5p, miR‐3613‐5p, miR‐455‐3p, miR‐5787, and miR‐548a‐3p as Prospective Noninvasive Biomarkers Following Allogeneic Hematopoietic Stem Cell Transplantation |
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