Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells

Glioblastoma (GBM) is a highly aggressive brain tumor associated with poor patient survival. The current standard treatment involves invasive surgery, radiotherapy, and chemotherapy employing temozolomide (TMZ). Resistance to TMZ is, however, a major challenge. Previous work from our group has ident...

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Veröffentlicht in:	DNA repair 2024-09, Vol.141, p.103715, Article 103715
Hauptverfasser:	Latancia, Marcela Teatin, Leandro, Giovana da Silva, Bastos, André Uchimura, Moreno, Natália Cestari, Ariwoola, Abu-Bakr Adetayo, Martins, Davi Jardim, Ashton, Nicholas William, Ribeiro, Victória Chaves, Hoch, Nicolas Carlos, Rocha, Clarissa Ribeiro Reily, Woodgate, Roger, Menck, Carlos Frederico Martins
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Alkylating - pharmacology Antineoplastic Agents, Alkylating - therapeutic use Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Cell Line, Tumor Cell Survival - drug effects Chemotherapy resistance DNA Damage DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA polymerase DNA Polymerase iota DNA Repair DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Drug Resistance, Neoplasm Gene Knockout Techniques Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioma Humans Temozolomide Temozolomide - pharmacology Translesion synthesis Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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