Antithrombotic properties of Tafamidis: An additional protective effect for transthyretin amyloid cardiomyopathy patients

Tafamidis is a molecular chaperone that stabilizes the transthyretin (TTR) homo-tetramer, preventing its dissociation and consequent deposition as amyloid fibrils in organ tissues. Tafamidis reduces mortality and the incidence of hospitalization for cardiovascular causes in patients with TTR amyloid...

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Veröffentlicht in:	Vascular pharmacology 2024-09, Vol.156, p.107411, Article 107411
Hauptverfasser:	Ministrini, Stefano, Niederberger, Rebecca, Akhmedov, Alexander, Beer, Georgia, Puspitasari, Yustina M., Franzini, Maria, Vergaro, Giuseppe, Cannie, Douglas E., Elliott, Perry, Kahr, Peter C., Hock, Christoph, Kobza, Richard, Toggweiler, Stefan, Lüscher, Thomas F., Camici, Giovanni G., Stämpfli, Simon F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amyloid Neuropathies, Familial - drug therapy Amyloid Neuropathies, Familial - genetics Amyloid Neuropathies, Familial - metabolism Amyloid Neuropathies, Familial - pathology Aorta - drug effects Aorta - metabolism Aorta - pathology Arterial thrombosis Benzoxazoles - pharmacology Cardiac amyloidosis Cardiomyopathies - drug therapy Cardiomyopathies - genetics Cardiomyopathies - metabolism Cardiomyopathies - pathology Cardiomyopathies - prevention & control Cells, Cultured Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial function Female Fibrinolytic Agents - pharmacology Humans Male Middle Aged Phosphorylation Pleiotropic effects Prealbumin - genetics Prealbumin - metabolism Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Tafamidis Thromboplastin - genetics Thromboplastin - metabolism Tumor Necrosis Factor-alpha - metabolism
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