Nrf2 affects DNA damage repair and cell apoptosis through regulating HR and the intrinsic Caspase-dependent apoptosis pathway in TK6 cells exposed to hydroquinone

Hydroquinone (HQ) is one of benzene metabolites that can cause oxidative stress damage and Homologous recombination repair (HR). A good deal of reactive oxygen species (ROS) generated by oxidative stress can trigger apoptotic signaling pathways. The nuclear factor erythroid 2-related factor 2 (Nrf2)...

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Veröffentlicht in:	Toxicology in vitro 2024-10, Vol.100, p.105901, Article 105901
Hauptverfasser:	Chen, Lin, Guo, Pu, Zhai, Lu, Yu, Lingxue, Zhu, Delong, Hu, Xiaoyi, Li, Zhuanzhuan, Chen, Yuting, Sun, Qian, Sun, Lei, Luo, Hao, Tang, Huanwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Caspase 9 - metabolism Caspase-9 Cell apoptosis Cell Line DNA Damage DNA Repair - drug effects Humans Hydroquinone Hydroquinones - toxicity NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 P53 Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Rad51 Recombinase - genetics Rad51 Recombinase - metabolism
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