Sublobar resection for small-sized non-small cell lung cancer: A comprehensive comparison between subsegmentectomy, segmentectomy and wedge resection
Subsegmentectomy has been adopted for non-small cell lung cancer (NSCLC) for decades. This study aimed to compare the features between subsegmentectomy, segmentectomy and wedge resection for NSCLC. NSCLC patients who underwent subsegmentectomy, segmentectomy, or wedge resection between 2014 and 2019...
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| Veröffentlicht in: | European journal of surgical oncology 2024-09, Vol.50 (9), p.108541, Article 108541 |
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| creator | Li, Zhihua Xu, Wenzheng Zhao, Chen Pan, Xianglong Zhou, Shengzhe Wu, Weibing Chen, Liang |
| description | Subsegmentectomy has been adopted for non-small cell lung cancer (NSCLC) for decades. This study aimed to compare the features between subsegmentectomy, segmentectomy and wedge resection for NSCLC.
NSCLC patients who underwent subsegmentectomy, segmentectomy, or wedge resection between 2014 and 2019 were retrospectively screened. Demographic, radiomic, and perioperative characteristics between patients were compared. Further, log-rank test, univariate and multivariate Cox regression were used for prognostic evaluation.
There were 276, 670, and 494 patients undergoing subsegmentectomy, segmentectomy, and wedge resection, respectively. Patients with segmentectomy and subsegmentectomy had larger tumor sizes and greater distances to the pleura than those with wedge resection. Subsegmentectomy and segmentectomy were more likely to achieve adequate surgical margins than wedge resection (82.0 % vs. 79.5 % vs. 64.7 %, P |
| doi_str_mv | 10.1016/j.ejso.2024.108541 |
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NSCLC patients who underwent subsegmentectomy, segmentectomy, or wedge resection between 2014 and 2019 were retrospectively screened. Demographic, radiomic, and perioperative characteristics between patients were compared. Further, log-rank test, univariate and multivariate Cox regression were used for prognostic evaluation.
There were 276, 670, and 494 patients undergoing subsegmentectomy, segmentectomy, and wedge resection, respectively. Patients with segmentectomy and subsegmentectomy had larger tumor sizes and greater distances to the pleura than those with wedge resection. Subsegmentectomy and segmentectomy were more likely to achieve adequate surgical margins than wedge resection (82.0 % vs. 79.5 % vs. 64.7 %, P < 0.001), which was especially true for nodules away from the pleura (80.2 % vs. 81.4 % vs. 55.8 %, P < 0.001). In addition, anatomic resection allowed for more lymph node dissection and required less preoperative localization than wedge reception. Subsegmentectomy preserved about two subsegments than segmentectomy (P < 0.001). The incidence of prolonged air leakage after subsegmentectomy (3.3 %) and wedge (1.8 %) was similar (P = 0.308). Notably, 66.8 % of patients who underwent segmentectomy or subsegmentectomy were considered unsuitable for wedge. During the follow-up (55.1 months), no tumor recurrence or death occurred in patients undergoing subsegmentectomy. No significant recurrence-free survival (P = 0.140) or overall survival (P = 0.370) difference existed between these groups.
Subsegmentectomy could achieve more adequate surgical margins than wedge resection and showed superiority for deep nodules. Compared to segmentectomy, subsegmentectomy could preserve more lung parenchyma.</description><identifier>ISSN: 0748-7983</identifier><identifier>ISSN: 1532-2157</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2024.108541</identifier><identifier>PMID: 39029208</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - surgery ; Female ; Humans ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Margins of Excision ; Middle Aged ; Oncological outcomes ; Pneumonectomy - methods ; Retrospective Studies ; Segmentectomy ; Subsegmentectomy ; Surgical margin ; Survival Rate ; Tumor Burden ; Wedge resection</subject><ispartof>European journal of surgical oncology, 2024-09, Vol.50 (9), p.108541, Article 108541</ispartof><rights>2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology</rights><rights>Copyright © 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c237t-ad09e626878803dfab45c48834cd6df47328ea3348aaf6e575161dd181239e6c3</cites><orcidid>0000-0002-7985-4273</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0748798324005936$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39029208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhihua</creatorcontrib><creatorcontrib>Xu, Wenzheng</creatorcontrib><creatorcontrib>Zhao, Chen</creatorcontrib><creatorcontrib>Pan, Xianglong</creatorcontrib><creatorcontrib>Zhou, Shengzhe</creatorcontrib><creatorcontrib>Wu, Weibing</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><title>Sublobar resection for small-sized non-small cell lung cancer: A comprehensive comparison between subsegmentectomy, segmentectomy and wedge resection</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Subsegmentectomy has been adopted for non-small cell lung cancer (NSCLC) for decades. This study aimed to compare the features between subsegmentectomy, segmentectomy and wedge resection for NSCLC.
NSCLC patients who underwent subsegmentectomy, segmentectomy, or wedge resection between 2014 and 2019 were retrospectively screened. Demographic, radiomic, and perioperative characteristics between patients were compared. Further, log-rank test, univariate and multivariate Cox regression were used for prognostic evaluation.
There were 276, 670, and 494 patients undergoing subsegmentectomy, segmentectomy, and wedge resection, respectively. Patients with segmentectomy and subsegmentectomy had larger tumor sizes and greater distances to the pleura than those with wedge resection. Subsegmentectomy and segmentectomy were more likely to achieve adequate surgical margins than wedge resection (82.0 % vs. 79.5 % vs. 64.7 %, P < 0.001), which was especially true for nodules away from the pleura (80.2 % vs. 81.4 % vs. 55.8 %, P < 0.001). In addition, anatomic resection allowed for more lymph node dissection and required less preoperative localization than wedge reception. Subsegmentectomy preserved about two subsegments than segmentectomy (P < 0.001). The incidence of prolonged air leakage after subsegmentectomy (3.3 %) and wedge (1.8 %) was similar (P = 0.308). Notably, 66.8 % of patients who underwent segmentectomy or subsegmentectomy were considered unsuitable for wedge. During the follow-up (55.1 months), no tumor recurrence or death occurred in patients undergoing subsegmentectomy. No significant recurrence-free survival (P = 0.140) or overall survival (P = 0.370) difference existed between these groups.
Subsegmentectomy could achieve more adequate surgical margins than wedge resection and showed superiority for deep nodules. Compared to segmentectomy, subsegmentectomy could preserve more lung parenchyma.</description><subject>Aged</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Margins of Excision</subject><subject>Middle Aged</subject><subject>Oncological outcomes</subject><subject>Pneumonectomy - methods</subject><subject>Retrospective Studies</subject><subject>Segmentectomy</subject><subject>Subsegmentectomy</subject><subject>Surgical margin</subject><subject>Survival Rate</subject><subject>Tumor Burden</subject><subject>Wedge resection</subject><issn>0748-7983</issn><issn>1532-2157</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctOHDEQtKKgsJD8QA7IxxyYjR_z8KBcEAoPCYkD5Gx57J6NVzP24p4BwX_kf-NlCVEuuXSrrKqSu4qQz5wtOeP11_US1hiXgokyP6iq5O_IgldSFIJXzXuyYE2piqZVcp8cIK4ZY61s2g9kX7ZMtIKpBfl1O3dD7EyiCRDs5GOgfUwURzMMBfpncDTEULxgaiGPYQ4rak2wkE7oKbVx3CT4CQH9A7wgkzxmmw6mR4BAce4QViOEKfvH8emY_gOpCY4-glvB3y98JHu9GRA-ve5D8uP8-93ZZXF9c3F1dnpdWCGbqTCOtVCLWjVKMel605WVLZWSpXW168tGCgVGylIZ09dQNRWvuXNccSGz0MpD8mXnu0nxfgac9Ohxe6QJEGfUkimhpFR1laliR7UpIibo9Sb50aQnzZne1qHXeluH3tahd3Vk0dGr_9yN4N4kf_LPhG87AuQrHzwkjdZDjtb5lKPQLvr_-f8GeKWfNQ</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Li, Zhihua</creator><creator>Xu, Wenzheng</creator><creator>Zhao, Chen</creator><creator>Pan, Xianglong</creator><creator>Zhou, Shengzhe</creator><creator>Wu, Weibing</creator><creator>Chen, Liang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7985-4273</orcidid></search><sort><creationdate>202409</creationdate><title>Sublobar resection for small-sized non-small cell lung cancer: A comprehensive comparison between subsegmentectomy, segmentectomy and wedge resection</title><author>Li, Zhihua ; Xu, Wenzheng ; Zhao, Chen ; Pan, Xianglong ; Zhou, Shengzhe ; Wu, Weibing ; Chen, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c237t-ad09e626878803dfab45c48834cd6df47328ea3348aaf6e575161dd181239e6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Margins of Excision</topic><topic>Middle Aged</topic><topic>Oncological outcomes</topic><topic>Pneumonectomy - methods</topic><topic>Retrospective Studies</topic><topic>Segmentectomy</topic><topic>Subsegmentectomy</topic><topic>Surgical margin</topic><topic>Survival Rate</topic><topic>Tumor Burden</topic><topic>Wedge resection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhihua</creatorcontrib><creatorcontrib>Xu, Wenzheng</creatorcontrib><creatorcontrib>Zhao, Chen</creatorcontrib><creatorcontrib>Pan, Xianglong</creatorcontrib><creatorcontrib>Zhou, Shengzhe</creatorcontrib><creatorcontrib>Wu, Weibing</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhihua</au><au>Xu, Wenzheng</au><au>Zhao, Chen</au><au>Pan, Xianglong</au><au>Zhou, Shengzhe</au><au>Wu, Weibing</au><au>Chen, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sublobar resection for small-sized non-small cell lung cancer: A comprehensive comparison between subsegmentectomy, segmentectomy and wedge resection</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2024-09</date><risdate>2024</risdate><volume>50</volume><issue>9</issue><spage>108541</spage><pages>108541-</pages><artnum>108541</artnum><issn>0748-7983</issn><issn>1532-2157</issn><eissn>1532-2157</eissn><abstract>Subsegmentectomy has been adopted for non-small cell lung cancer (NSCLC) for decades. This study aimed to compare the features between subsegmentectomy, segmentectomy and wedge resection for NSCLC.
NSCLC patients who underwent subsegmentectomy, segmentectomy, or wedge resection between 2014 and 2019 were retrospectively screened. Demographic, radiomic, and perioperative characteristics between patients were compared. Further, log-rank test, univariate and multivariate Cox regression were used for prognostic evaluation.
There were 276, 670, and 494 patients undergoing subsegmentectomy, segmentectomy, and wedge resection, respectively. Patients with segmentectomy and subsegmentectomy had larger tumor sizes and greater distances to the pleura than those with wedge resection. Subsegmentectomy and segmentectomy were more likely to achieve adequate surgical margins than wedge resection (82.0 % vs. 79.5 % vs. 64.7 %, P < 0.001), which was especially true for nodules away from the pleura (80.2 % vs. 81.4 % vs. 55.8 %, P < 0.001). In addition, anatomic resection allowed for more lymph node dissection and required less preoperative localization than wedge reception. Subsegmentectomy preserved about two subsegments than segmentectomy (P < 0.001). The incidence of prolonged air leakage after subsegmentectomy (3.3 %) and wedge (1.8 %) was similar (P = 0.308). Notably, 66.8 % of patients who underwent segmentectomy or subsegmentectomy were considered unsuitable for wedge. During the follow-up (55.1 months), no tumor recurrence or death occurred in patients undergoing subsegmentectomy. No significant recurrence-free survival (P = 0.140) or overall survival (P = 0.370) difference existed between these groups.
Subsegmentectomy could achieve more adequate surgical margins than wedge resection and showed superiority for deep nodules. Compared to segmentectomy, subsegmentectomy could preserve more lung parenchyma.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39029208</pmid><doi>10.1016/j.ejso.2024.108541</doi><orcidid>https://orcid.org/0000-0002-7985-4273</orcidid></addata></record> |
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| subjects | Aged Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Female Humans Lung Neoplasms - pathology Lung Neoplasms - surgery Male Margins of Excision Middle Aged Oncological outcomes Pneumonectomy - methods Retrospective Studies Segmentectomy Subsegmentectomy Surgical margin Survival Rate Tumor Burden Wedge resection |
| title | Sublobar resection for small-sized non-small cell lung cancer: A comprehensive comparison between subsegmentectomy, segmentectomy and wedge resection |
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