Risk and survival of patients with non-small cell lung cancer and pre-existing autoimmune disorders receiving immune checkpoint blockade therapy: Survival analysis with inverse probability weighting from a nationwide, multi-institutional, retrospective study (NEJ047)

•NSCLC diagnosis within 1 year of AID diagnosis increases risk of AID flares.•The safety profiles of combination immunotherapy monotherapy were comparable.•After inverse probability weighting, ICB versus without ICB prolonged survival.•These results support the use of ICB in patients with NSCLC and...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2024-08, Vol.194, p.107894, Article 107894
Hauptverfasser:	Asao, Tetsuhiko, Shukuya, Takehito, Uemura, Kohei, Kitadai, Rui, Yamamoto, Gaku, Mouri, Atsuto, Tamaoka, Meiyo, Imai, Ryosuke, Tsukita, Yoko, Isobe, Kazutoshi, Watanabe, Satoshi, Kamimura, Mitsuhiro, Morita, Ryo, Kudo, Keita, Inomata, Minehiko, Tateishi, Kazunari, Kakinuma, Kazutaka, Yoshioka, Hiroshige, Namba, Yukiko, Sumiyoshi, Issei, Nakagawa, Taku, Watanabe, Kana, Kobayashi, Kunihiko, Takahashi, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Autoimmune Diseases - complications Autoimmune Diseases - drug therapy Autoimmune Diseases - mortality Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - mortality Female Humans Immune checkpoint blockade Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - therapeutic use Inverse probability weighting Japan - epidemiology Lung Neoplasms - drug therapy Lung Neoplasms - mortality Male Middle Aged Non-small cell lung cancer Pre-existing autoimmune disorders Retrospective Studies Survival Analysis Survival Rate
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