Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9

This study investigated the intervention effect of slow-velocity eccentric-only resistance training on type 2 diabetic mellitus (T2DM) patients based on the role of matrix metalloproteinase-2 and -9 (MMP-2 and -9) in regulating extracellular matrix homeostasis. 50 T2DM patients were randomly divided...

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Veröffentlicht in:	Medicine (Baltimore) 2024-07, Vol.103 (29), p.e38855
Hauptverfasser:	Qian, Zhao, Ping, Liu, Dongming, Xu, Xuelin, Zhang
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Sprache:	eng
Schlagworte:	Adult Blood Glucose - analysis Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - therapy Female Glycated Hemoglobin - analysis Humans Insulin - blood Insulin Resistance - physiology Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Middle Aged Muscle Strength - physiology Resistance Training - methods
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creator	Qian, Zhao Ping, Liu Dongming, Xu Xuelin, Zhang
description	This study investigated the intervention effect of slow-velocity eccentric-only resistance training on type 2 diabetic mellitus (T2DM) patients based on the role of matrix metalloproteinase-2 and -9 (MMP-2 and -9) in regulating extracellular matrix homeostasis. 50 T2DM patients were randomly divided into the slow-velocity eccentric-only resistance training group (E) and control group (C). The E group performed eccentric-only resistance training 3 times a week, every other day for 10 weeks, while the C group did not. Blood samples were collected before and after training, and subjects were tested for changes in clinical parameters, insulin resistance indices [fasting insulin, homeostatic model assessment insulin resistance (HOMA-IR)], MMP-2 and -9, and hydroxyproline, and muscle strength (12-RM), respectively. After 10 weeks of training, the E group showed significant decreases in fasting glucose (P
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The E group performed eccentric-only resistance training 3 times a week, every other day for 10 weeks, while the C group did not. Blood samples were collected before and after training, and subjects were tested for changes in clinical parameters, insulin resistance indices [fasting insulin, homeostatic model assessment insulin resistance (HOMA-IR)], MMP-2 and -9, and hydroxyproline, and muscle strength (12-RM), respectively. After 10 weeks of training, the E group showed significant decreases in fasting glucose (P < .05), insulin (P < .05), insulin resistance indices (P < .05), hemoglobin A1c (HbA1c) (P < .01), triglycerides (P = .06) and MMP-2 (P < .05), while total cholesterol (P < .05), MMP-9 (P < .05), hydroxyproline (P < .01), Creatine Kinase (CK) (P < .05), and muscle strength (P < .001) significantly increased. There were no significant changes in the count of neutrophil, lymphocyte and platelet, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). Compared with the C group, the E group showed a trend of a significant decrease in triglyceride (P < .05), lymphocyte count (P < .05), fasting glucose (P = .07), and plasma MMP-2 (P < .05), while MMP-9 (P < .05), hydroxyproline (P < .001), and muscle strength (P < .01) significantly increased. However, no significant changes were observed in insulin and insulin resistance indices, HbA1c, total cholesterol, HDL-c, LDL-c, CK, and other inflammatory indicators. Slow-velocity eccentric-only resistance training was beneficial for T2DM, but the potential role of MMP-2 and -9 in regulating extracellular matrix homeostasis is very different in T2DM patients.]]></description><identifier>ISSN: 0025-7974</identifier><identifier>ISSN: 1536-5964</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000038855</identifier><identifier>PMID: 39029066</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Blood Glucose - analysis ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - therapy ; Female ; Glycated Hemoglobin - analysis ; Humans ; Insulin - blood ; Insulin Resistance - physiology ; Male ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 9 - blood ; Middle Aged ; Muscle Strength - physiology ; Resistance Training - methods</subject><ispartof>Medicine (Baltimore), 2024-07, Vol.103 (29), p.e38855</ispartof><rights>Copyright © 2024 the Author(s). 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The E group performed eccentric-only resistance training 3 times a week, every other day for 10 weeks, while the C group did not. Blood samples were collected before and after training, and subjects were tested for changes in clinical parameters, insulin resistance indices [fasting insulin, homeostatic model assessment insulin resistance (HOMA-IR)], MMP-2 and -9, and hydroxyproline, and muscle strength (12-RM), respectively. After 10 weeks of training, the E group showed significant decreases in fasting glucose (P < .05), insulin (P < .05), insulin resistance indices (P < .05), hemoglobin A1c (HbA1c) (P < .01), triglycerides (P = .06) and MMP-2 (P < .05), while total cholesterol (P < .05), MMP-9 (P < .05), hydroxyproline (P < .01), Creatine Kinase (CK) (P < .05), and muscle strength (P < .001) significantly increased. There were no significant changes in the count of neutrophil, lymphocyte and platelet, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). Compared with the C group, the E group showed a trend of a significant decrease in triglyceride (P < .05), lymphocyte count (P < .05), fasting glucose (P = .07), and plasma MMP-2 (P < .05), while MMP-9 (P < .05), hydroxyproline (P < .001), and muscle strength (P < .01) significantly increased. However, no significant changes were observed in insulin and insulin resistance indices, HbA1c, total cholesterol, HDL-c, LDL-c, CK, and other inflammatory indicators. Slow-velocity eccentric-only resistance training was beneficial for T2DM, but the potential role of MMP-2 and -9 in regulating extracellular matrix homeostasis is very different in T2DM patients.]]></description><subject>Adult</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Female</subject><subject>Glycated Hemoglobin - analysis</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Middle Aged</subject><subject>Muscle Strength - physiology</subject><subject>Resistance Training - methods</subject><issn>0025-7974</issn><issn>1536-5964</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtKxDAQhoMo7rr6BILk0ptoTm2TS1mPsIuCel3SZLpEerJJV_oIvrUVT-DcDAPzf3P4ETpm9IxRnZ2vL8_oXwilkmQHzVkiUpLoVO6iOaU8IZnO5AwdhPBCKRMZl_toJjTlmqbpHL0_Vu0b2ULVWh9HDNZCE3tvSdtUI-4h-BBNYwHH3vjGNxvs665vtxBwGOsutnXAbYnj2AHm2HlTQPQW11BVPg4Bdyb6iRhw8UnbDNVUT5CuMqE2eL1-IBybxmGiD9FeaaoAR995gZ6vr56Wt2R1f3O3vFgRywWNhBspCycLCZDxBCRPrXOsLDOumaKJ0Mo6qZUzJVNOscTY0gqwkmdSuCwtxQKdfnGnM14HCDGvfbDTvqaBdgi5oIorIeTEWiDx1Wr7NoQeyrzrfW36MWc0__QgX1_m_z2YVCffA4aiBver-Xm6-ACuEYPr</recordid><startdate>20240719</startdate><enddate>20240719</enddate><creator>Qian, Zhao</creator><creator>Ping, Liu</creator><creator>Dongming, Xu</creator><creator>Xuelin, Zhang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6681-7804</orcidid></search><sort><creationdate>20240719</creationdate><title>Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9</title><author>Qian, Zhao ; Ping, Liu ; Dongming, Xu ; Xuelin, Zhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c230t-2a44bd4b4ee725e426cdd1ff7291805398cd498daf18d815acfc3ec42743d76f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Female</topic><topic>Glycated Hemoglobin - analysis</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - blood</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Middle Aged</topic><topic>Muscle Strength - physiology</topic><topic>Resistance Training - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qian, Zhao</creatorcontrib><creatorcontrib>Ping, Liu</creatorcontrib><creatorcontrib>Dongming, Xu</creatorcontrib><creatorcontrib>Xuelin, Zhang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qian, Zhao</au><au>Ping, Liu</au><au>Dongming, Xu</au><au>Xuelin, Zhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2024-07-19</date><risdate>2024</risdate><volume>103</volume><issue>29</issue><spage>e38855</spage><pages>e38855-</pages><issn>0025-7974</issn><issn>1536-5964</issn><eissn>1536-5964</eissn><abstract><![CDATA[This study investigated the intervention effect of slow-velocity eccentric-only resistance training on type 2 diabetic mellitus (T2DM) patients based on the role of matrix metalloproteinase-2 and -9 (MMP-2 and -9) in regulating extracellular matrix homeostasis. 50 T2DM patients were randomly divided into the slow-velocity eccentric-only resistance training group (E) and control group (C). The E group performed eccentric-only resistance training 3 times a week, every other day for 10 weeks, while the C group did not. Blood samples were collected before and after training, and subjects were tested for changes in clinical parameters, insulin resistance indices [fasting insulin, homeostatic model assessment insulin resistance (HOMA-IR)], MMP-2 and -9, and hydroxyproline, and muscle strength (12-RM), respectively. After 10 weeks of training, the E group showed significant decreases in fasting glucose (P < .05), insulin (P < .05), insulin resistance indices (P < .05), hemoglobin A1c (HbA1c) (P < .01), triglycerides (P = .06) and MMP-2 (P < .05), while total cholesterol (P < .05), MMP-9 (P < .05), hydroxyproline (P < .01), Creatine Kinase (CK) (P < .05), and muscle strength (P < .001) significantly increased. There were no significant changes in the count of neutrophil, lymphocyte and platelet, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). Compared with the C group, the E group showed a trend of a significant decrease in triglyceride (P < .05), lymphocyte count (P < .05), fasting glucose (P = .07), and plasma MMP-2 (P < .05), while MMP-9 (P < .05), hydroxyproline (P < .001), and muscle strength (P < .01) significantly increased. However, no significant changes were observed in insulin and insulin resistance indices, HbA1c, total cholesterol, HDL-c, LDL-c, CK, and other inflammatory indicators. Slow-velocity eccentric-only resistance training was beneficial for T2DM, but the potential role of MMP-2 and -9 in regulating extracellular matrix homeostasis is very different in T2DM patients.]]></abstract><cop>United States</cop><pmid>39029066</pmid><doi>10.1097/MD.0000000000038855</doi><orcidid>https://orcid.org/0000-0001-6681-7804</orcidid><oa>free_for_read</oa></addata></record>
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subjects	Adult Blood Glucose - analysis Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - therapy Female Glycated Hemoglobin - analysis Humans Insulin - blood Insulin Resistance - physiology Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Middle Aged Muscle Strength - physiology Resistance Training - methods
title	Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9
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