Stem Cells in Bone Tissue Engineering: Progress, Promises and Challenges
Bone defects from accidents, congenital conditions, and age-related diseases significantly impact quality of life. Recent advancements in bone tissue engineering (TE) involve biomaterial scaffolds, patient-derived cells, and bioactive agents, enabling functional bone regeneration. Stem cells, obtain...
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| Veröffentlicht in: | Stem cell reviews and reports 2024-10, Vol.20 (7), p.1692-1731 |
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| creator | Augustine, Robin Gezek, Mert Nikolopoulos, Vasilios K. Buck, Paige Lauren Bostanci, Nazli Seray Camci-Unal, Gulden |
| description | Bone defects from accidents, congenital conditions, and age-related diseases significantly impact quality of life. Recent advancements in bone tissue engineering (TE) involve biomaterial scaffolds, patient-derived cells, and bioactive agents, enabling functional bone regeneration. Stem cells, obtained from numerous sources including umbilical cord blood, adipose tissue, bone marrow, and dental pulp, hold immense potential in bone TE. Induced pluripotent stem cells and genetically modified stem cells can also be used. Proper manipulation of physical, chemical, and biological stimulation is crucial for their proliferation, maintenance, and differentiation. Stem cells contribute to osteogenesis, osteoinduction, angiogenesis, and mineralization, essential for bone regeneration. This review provides an overview of the latest developments in stem cell-based TE for repairing and regenerating defective bones.
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| doi_str_mv | 10.1007/s12015-024-10738-y |
| format | Article |
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Graphical Abstract</description><subject>Adipose tissue</subject><subject>Age</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Body fat</subject><subject>Bone and Bones - cytology</subject><subject>Bone biomaterials</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Bone Regeneration</subject><subject>Calcium phosphates</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cord blood</subject><subject>Dental pulp</subject><subject>Genetic engineering</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Mineralization</subject><subject>Nanostructured materials</subject><subject>Osteogenesis</subject><subject>Pluripotency</subject><subject>Quality of life</subject><subject>Regeneration</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Stem Cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds</subject><subject>Umbilical cord</subject><issn>2629-3269</issn><issn>2629-3277</issn><issn>2629-3277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EolXpH2BAkVgYCJztJI7ZoCofUiWQ6G4lzrWkSp3ia4b-e1xaisTA5Bue9_Xdw9g5hxsOoG6JC-BpDCKJOSiZx5sj1heZ0LEUSh0f5kz32JBoAQBCQhIyp6wnNYg84VmfPb-vcRmNsGkoql300DqMpjVRh9HYzWuH6Gs3v4vefDv3SHS9nZY1IUWFq6LRR9E06OZIZ-xkVjSEw_07YNPH8XT0HE9en15G95PYijRbxxWorOAy1QJL5NYKrWSZ5lbxEnJhK2FnlmcabJnrRKVponihsrTKMUOQWg7Y1a525dvPDmltwjI2rF84bDsyMrSEw7WQAb38gy7azruwnJGccyWE5hAosaOsb4k8zszK18vCbwwHszVtdqZNMG2-TZtNCF3sq7tyidUh8uM1AHIH0GrrD_3v3__UfgFCr4ba</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Augustine, Robin</creator><creator>Gezek, Mert</creator><creator>Nikolopoulos, Vasilios K.</creator><creator>Buck, Paige Lauren</creator><creator>Bostanci, Nazli Seray</creator><creator>Camci-Unal, Gulden</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4258-844X</orcidid></search><sort><creationdate>20241001</creationdate><title>Stem Cells in Bone Tissue Engineering: Progress, Promises and Challenges</title><author>Augustine, Robin ; 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Recent advancements in bone tissue engineering (TE) involve biomaterial scaffolds, patient-derived cells, and bioactive agents, enabling functional bone regeneration. Stem cells, obtained from numerous sources including umbilical cord blood, adipose tissue, bone marrow, and dental pulp, hold immense potential in bone TE. Induced pluripotent stem cells and genetically modified stem cells can also be used. Proper manipulation of physical, chemical, and biological stimulation is crucial for their proliferation, maintenance, and differentiation. Stem cells contribute to osteogenesis, osteoinduction, angiogenesis, and mineralization, essential for bone regeneration. This review provides an overview of the latest developments in stem cell-based TE for repairing and regenerating defective bones.
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| subjects | Adipose tissue Age Angiogenesis Animals Biomedical and Life Sciences Biomedical Engineering and Bioengineering Body fat Bone and Bones - cytology Bone biomaterials Bone growth Bone marrow Bone Regeneration Calcium phosphates Cell Biology Cell Differentiation Cell growth Cell proliferation Cord blood Dental pulp Genetic engineering Growth factors Humans Life Sciences Mineralization Nanostructured materials Osteogenesis Pluripotency Quality of life Regeneration Regenerative Medicine/Tissue Engineering Stem Cells Stem Cells - cytology Stem Cells - metabolism Tissue engineering Tissue Engineering - methods Tissue Scaffolds Umbilical cord |
| title | Stem Cells in Bone Tissue Engineering: Progress, Promises and Challenges |
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