Association of interleukin-1 and interleukin-6 levels in lateralized temporal epilepsy patients
To explore the clinical significance of interleukin-1 and interleukin-6 in the development of lateralized temporal epilepsy. The prospective study was conducted from January to April of 2022 at the Neurology Department of Training and Research Hospital, Istanbul Medeniyet University, Turkey, and com...
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| Veröffentlicht in: | Journal of the Pakistan Medical Association 2024-07, Vol.74 (7), p.1255-1260 |
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| creator | Varoglu, Asuman Orhan Alvarisli, Aysenur Keskin, Havva Erman, Hayriye |
| description | To explore the clinical significance of interleukin-1 and interleukin-6 in the development of lateralized temporal epilepsy.
The prospective study was conducted from January to April of 2022 at the Neurology Department of Training and Research Hospital, Istanbul Medeniyet University, Turkey, and comprised patients with lateralized temporal epilepsy aged 18-86 years who were in the interictal period in group A and healthy controls in group B. The levels of interleukin-1 and interleukin-6 of patients in both groups were compared. Data was analysed using SPSS 25.
Of the 92 subjects, 60(65.2%) were in group A; 35(58.3%) were males and 25(41.7%) were females with a median age of 37.5 years (interquartile range: 2.2-42.7 years). There were 32(34.8%) subjects in group B; 19(40.6%) females and 13(40.6%) males with a median age of 40.5 years (interquartile range: 25-50 years) (p>0.05). Within group A, 41(68.3%) patients had left-sided epilepsy and 19(31.7%) had right-sided epilepsy (p |
| doi_str_mv | 10.47391/JPMA.10291 |
| format | Article |
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The prospective study was conducted from January to April of 2022 at the Neurology Department of Training and Research Hospital, Istanbul Medeniyet University, Turkey, and comprised patients with lateralized temporal epilepsy aged 18-86 years who were in the interictal period in group A and healthy controls in group B. The levels of interleukin-1 and interleukin-6 of patients in both groups were compared. Data was analysed using SPSS 25.
Of the 92 subjects, 60(65.2%) were in group A; 35(58.3%) were males and 25(41.7%) were females with a median age of 37.5 years (interquartile range: 2.2-42.7 years). There were 32(34.8%) subjects in group B; 19(40.6%) females and 13(40.6%) males with a median age of 40.5 years (interquartile range: 25-50 years) (p>0.05). Within group A, 41(68.3%) patients had left-sided epilepsy and 19(31.7%) had right-sided epilepsy (p<0.001). Both interleukin-1 and interleukin-6 levels were lower in group A than in group B (p<0.001). Both interleukin levels did not significantly differ between right and leftlateralised temporal seizures (p=0.44). In the left-lateralized temporal seizures, interleukin-1 levels correlated with epilepsy duration (p<0.006), lower onset age (p<0.050), and presence of prenatal risk (p<0.028). Interleukin-1 and interleukin-6 levels were positively correlated with each other for lateralized temporal epileptic hemispheres (p<0.001).
Interleukin-1 level was correlated with epilepsy duration, lower onset age, and presence of prenatal risk in the left-lateralized temporal epilepsy.]]></description><identifier>ISSN: 0030-9982</identifier><identifier>EISSN: 0030-9982</identifier><identifier>DOI: 10.47391/JPMA.10291</identifier><identifier>PMID: 39028050</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Diagnosis ; Epilepsy, Temporal Lobe - blood ; Female ; Health aspects ; Humans ; Interleukin-1 ; Interleukin-1 - blood ; Interleukin-6 ; Interleukin-6 - blood ; Male ; Measurement ; Middle Aged ; Prospective Studies ; Risk factors ; Temporal lobe epilepsy ; Young Adult</subject><ispartof>Journal of the Pakistan Medical Association, 2024-07, Vol.74 (7), p.1255-1260</ispartof><rights>COPYRIGHT 2024 Knowledge Bylanes</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39028050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varoglu, Asuman Orhan</creatorcontrib><creatorcontrib>Alvarisli, Aysenur</creatorcontrib><creatorcontrib>Keskin, Havva</creatorcontrib><creatorcontrib>Erman, Hayriye</creatorcontrib><title>Association of interleukin-1 and interleukin-6 levels in lateralized temporal epilepsy patients</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description><![CDATA[To explore the clinical significance of interleukin-1 and interleukin-6 in the development of lateralized temporal epilepsy.
The prospective study was conducted from January to April of 2022 at the Neurology Department of Training and Research Hospital, Istanbul Medeniyet University, Turkey, and comprised patients with lateralized temporal epilepsy aged 18-86 years who were in the interictal period in group A and healthy controls in group B. The levels of interleukin-1 and interleukin-6 of patients in both groups were compared. Data was analysed using SPSS 25.
Of the 92 subjects, 60(65.2%) were in group A; 35(58.3%) were males and 25(41.7%) were females with a median age of 37.5 years (interquartile range: 2.2-42.7 years). There were 32(34.8%) subjects in group B; 19(40.6%) females and 13(40.6%) males with a median age of 40.5 years (interquartile range: 25-50 years) (p>0.05). Within group A, 41(68.3%) patients had left-sided epilepsy and 19(31.7%) had right-sided epilepsy (p<0.001). Both interleukin-1 and interleukin-6 levels were lower in group A than in group B (p<0.001). Both interleukin levels did not significantly differ between right and leftlateralised temporal seizures (p=0.44). In the left-lateralized temporal seizures, interleukin-1 levels correlated with epilepsy duration (p<0.006), lower onset age (p<0.050), and presence of prenatal risk (p<0.028). Interleukin-1 and interleukin-6 levels were positively correlated with each other for lateralized temporal epileptic hemispheres (p<0.001).
Interleukin-1 level was correlated with epilepsy duration, lower onset age, and presence of prenatal risk in the left-lateralized temporal epilepsy.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Diagnosis</subject><subject>Epilepsy, Temporal Lobe - blood</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Interleukin-1</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Measurement</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>Temporal lobe epilepsy</subject><subject>Young Adult</subject><issn>0030-9982</issn><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1r3DAQxUVJ6CbbnnoPhkAIBG9HkleWj8vSJg0J7aE9C8keN0pky7HswOavj_ajZReCDtI8fvPg6RHyhcIsy3lBv97-ul_MKLCCfiAnABzSopDsaO89IachPAIwMQf4SCa8ACZhDidELULwpdWD9W3i68S2A_YOxyfbpjTRbXWgiMThC7oQxcTpqGtnX7FKBmw6H4cEO-uwC6uki47YDuETOa61C_h5d0_Jn-_ffi9v0ruf1z-Wi7u0ZPl8SAVwzowxnJpM1trk-TzjMmOs4lWVMSmZzmIQXQnMjcxNUdOaFaYoGSu5FJRPyeXWt-v984hhUI0NJTqnW_RjUBwkE9GH5xE936J_tUNl29oPvS7XuFpIoCC4ECJSs3eoeCpsbOlbrGPSw4WLvYUH1G54CN6N658Nh-DVFix7H0KPtep62-h-pSioTaNq3ajaNBrps12w0TRY_Wf_VcjfAAJ2mUM</recordid><startdate>20240731</startdate><enddate>20240731</enddate><creator>Varoglu, Asuman Orhan</creator><creator>Alvarisli, Aysenur</creator><creator>Keskin, Havva</creator><creator>Erman, Hayriye</creator><general>Knowledge Bylanes</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240731</creationdate><title>Association of interleukin-1 and interleukin-6 levels in lateralized temporal epilepsy patients</title><author>Varoglu, Asuman Orhan ; Alvarisli, Aysenur ; Keskin, Havva ; Erman, Hayriye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-60332bbb31b48fab775438422d3dd42882a4998ad6e7b87b9f1f29b9c22c38613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Diagnosis</topic><topic>Epilepsy, Temporal Lobe - blood</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Interleukin-1</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-6</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Measurement</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Risk factors</topic><topic>Temporal lobe epilepsy</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Varoglu, Asuman Orhan</creatorcontrib><creatorcontrib>Alvarisli, Aysenur</creatorcontrib><creatorcontrib>Keskin, Havva</creatorcontrib><creatorcontrib>Erman, Hayriye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varoglu, Asuman Orhan</au><au>Alvarisli, Aysenur</au><au>Keskin, Havva</au><au>Erman, Hayriye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of interleukin-1 and interleukin-6 levels in lateralized temporal epilepsy patients</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2024-07-31</date><risdate>2024</risdate><volume>74</volume><issue>7</issue><spage>1255</spage><epage>1260</epage><pages>1255-1260</pages><issn>0030-9982</issn><eissn>0030-9982</eissn><abstract><![CDATA[To explore the clinical significance of interleukin-1 and interleukin-6 in the development of lateralized temporal epilepsy.
The prospective study was conducted from January to April of 2022 at the Neurology Department of Training and Research Hospital, Istanbul Medeniyet University, Turkey, and comprised patients with lateralized temporal epilepsy aged 18-86 years who were in the interictal period in group A and healthy controls in group B. The levels of interleukin-1 and interleukin-6 of patients in both groups were compared. Data was analysed using SPSS 25.
Of the 92 subjects, 60(65.2%) were in group A; 35(58.3%) were males and 25(41.7%) were females with a median age of 37.5 years (interquartile range: 2.2-42.7 years). There were 32(34.8%) subjects in group B; 19(40.6%) females and 13(40.6%) males with a median age of 40.5 years (interquartile range: 25-50 years) (p>0.05). Within group A, 41(68.3%) patients had left-sided epilepsy and 19(31.7%) had right-sided epilepsy (p<0.001). Both interleukin-1 and interleukin-6 levels were lower in group A than in group B (p<0.001). Both interleukin levels did not significantly differ between right and leftlateralised temporal seizures (p=0.44). In the left-lateralized temporal seizures, interleukin-1 levels correlated with epilepsy duration (p<0.006), lower onset age (p<0.050), and presence of prenatal risk (p<0.028). Interleukin-1 and interleukin-6 levels were positively correlated with each other for lateralized temporal epileptic hemispheres (p<0.001).
Interleukin-1 level was correlated with epilepsy duration, lower onset age, and presence of prenatal risk in the left-lateralized temporal epilepsy.]]></abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>39028050</pmid><doi>10.47391/JPMA.10291</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Case-Control Studies Diagnosis Epilepsy, Temporal Lobe - blood Female Health aspects Humans Interleukin-1 Interleukin-1 - blood Interleukin-6 Interleukin-6 - blood Male Measurement Middle Aged Prospective Studies Risk factors Temporal lobe epilepsy Young Adult |
| title | Association of interleukin-1 and interleukin-6 levels in lateralized temporal epilepsy patients |
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