Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans
[Display omitted] Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that L...
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| Veröffentlicht in: | Neuroscience letters 2024-08, Vol.837, p.137903, Article 137903 |
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| container_title | Neuroscience letters |
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| creator | Ornelas, Isis M. Carrilho, Beatriz de S. Ventura, Matheus Antonio V. de C. Domith, Ivan de V. Silveira, Christiane M. dos Santos, Vanessa F. Delou, João M. Moll, Francisco Pereira, Henrique Marcelo G. Junqueira, Magno Aguilaniu, Hugo Rehen, Stevens |
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Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research. |
| doi_str_mv | 10.1016/j.neulet.2024.137903 |
| format | Article |
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Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.</description><identifier>ISSN: 0304-3940</identifier><identifier>ISSN: 1872-7972</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2024.137903</identifier><identifier>PMID: 39025433</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>C. elegans ; Locomotion ; Lysergic acid diethylamide ; Psychedelics ; SER-4 receptor ; Serotonin</subject><ispartof>Neuroscience letters, 2024-08, Vol.837, p.137903, Article 137903</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-51b9272046fbd0ecca4dfd884a2502c373331b73072fb696ede9ba8385d5db1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2024.137903$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39025433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ornelas, Isis M.</creatorcontrib><creatorcontrib>Carrilho, Beatriz de S.</creatorcontrib><creatorcontrib>Ventura, Matheus Antonio V. de C.</creatorcontrib><creatorcontrib>Domith, Ivan</creatorcontrib><creatorcontrib>de V. Silveira, Christiane M.</creatorcontrib><creatorcontrib>dos Santos, Vanessa F.</creatorcontrib><creatorcontrib>Delou, João M.</creatorcontrib><creatorcontrib>Moll, Francisco</creatorcontrib><creatorcontrib>Pereira, Henrique Marcelo G.</creatorcontrib><creatorcontrib>Junqueira, Magno</creatorcontrib><creatorcontrib>Aguilaniu, Hugo</creatorcontrib><creatorcontrib>Rehen, Stevens</creatorcontrib><title>Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>[Display omitted]
Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.</description><subject>C. elegans</subject><subject>Locomotion</subject><subject>Lysergic acid diethylamide</subject><subject>Psychedelics</subject><subject>SER-4 receptor</subject><subject>Serotonin</subject><issn>0304-3940</issn><issn>1872-7972</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMlKA0EQhhtRTIy-gcgcvUysXma7CBLcIJCLnpteajIdZondM0Le3gkTPXoqKL6_fuoj5JbCkgJNH3bLFoca-yUDJpaUZwXwMzKnecbirMjYOZkDBxHzQsCMXIWwA4CEJuKSzHgBLBGcz8lmfQjot85EyjgbWYd9dahV4yxGrrWDwRBprNS367yqI1OpdjuuXButFLadr5S2rnchwhq3qg3X5KJUdcCb01yQz5fnj9VbvN68vq-e1rFhgvZxQnXBMgYiLbUFNEYJW9o8F4olwAzPOOdUZxwyVuq0SNFioVXO88QmVlPkC3I_3d377mvA0MvGBYN1rVrshiA55CxlOaf5iIoJNb4LwWMp9941yh8kBXlUKXdyUimPKuWkcozdnRoG3aD9C_26G4HHCcDxz2-HXgbjsDVonUfTS9u5_xt-AE9nhz0</recordid><startdate>20240810</startdate><enddate>20240810</enddate><creator>Ornelas, Isis M.</creator><creator>Carrilho, Beatriz de S.</creator><creator>Ventura, Matheus Antonio V. de C.</creator><creator>Domith, Ivan</creator><creator>de V. Silveira, Christiane M.</creator><creator>dos Santos, Vanessa F.</creator><creator>Delou, João M.</creator><creator>Moll, Francisco</creator><creator>Pereira, Henrique Marcelo G.</creator><creator>Junqueira, Magno</creator><creator>Aguilaniu, Hugo</creator><creator>Rehen, Stevens</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240810</creationdate><title>Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans</title><author>Ornelas, Isis M. ; Carrilho, Beatriz de S. ; Ventura, Matheus Antonio V. de C. ; Domith, Ivan ; de V. Silveira, Christiane M. ; dos Santos, Vanessa F. ; Delou, João M. ; Moll, Francisco ; Pereira, Henrique Marcelo G. ; Junqueira, Magno ; Aguilaniu, Hugo ; Rehen, Stevens</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-51b9272046fbd0ecca4dfd884a2502c373331b73072fb696ede9ba8385d5db1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>C. elegans</topic><topic>Locomotion</topic><topic>Lysergic acid diethylamide</topic><topic>Psychedelics</topic><topic>SER-4 receptor</topic><topic>Serotonin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ornelas, Isis M.</creatorcontrib><creatorcontrib>Carrilho, Beatriz de S.</creatorcontrib><creatorcontrib>Ventura, Matheus Antonio V. de C.</creatorcontrib><creatorcontrib>Domith, Ivan</creatorcontrib><creatorcontrib>de V. Silveira, Christiane M.</creatorcontrib><creatorcontrib>dos Santos, Vanessa F.</creatorcontrib><creatorcontrib>Delou, João M.</creatorcontrib><creatorcontrib>Moll, Francisco</creatorcontrib><creatorcontrib>Pereira, Henrique Marcelo G.</creatorcontrib><creatorcontrib>Junqueira, Magno</creatorcontrib><creatorcontrib>Aguilaniu, Hugo</creatorcontrib><creatorcontrib>Rehen, Stevens</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ornelas, Isis M.</au><au>Carrilho, Beatriz de S.</au><au>Ventura, Matheus Antonio V. de C.</au><au>Domith, Ivan</au><au>de V. Silveira, Christiane M.</au><au>dos Santos, Vanessa F.</au><au>Delou, João M.</au><au>Moll, Francisco</au><au>Pereira, Henrique Marcelo G.</au><au>Junqueira, Magno</au><au>Aguilaniu, Hugo</au><au>Rehen, Stevens</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2024-08-10</date><risdate>2024</risdate><volume>837</volume><spage>137903</spage><pages>137903-</pages><artnum>137903</artnum><issn>0304-3940</issn><issn>1872-7972</issn><eissn>1872-7972</eissn><abstract>[Display omitted]
Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>39025433</pmid><doi>10.1016/j.neulet.2024.137903</doi></addata></record> |
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| issn | 0304-3940 1872-7972 1872-7972 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | C. elegans Locomotion Lysergic acid diethylamide Psychedelics SER-4 receptor Serotonin |
| title | Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans |
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