Analysis of Fertility Prognosis and Risk Factors in Patients Post-Gestational Trophoblastic Disease
To retrospectively analyze the fertility outcomes and prognosis of gestational trophoblastic disease (GTD) patients, providing a basis for targeted fertility guidance and counseling. 82 GTD patients of childbearing age who received treatment at the Obstetrics and Gynecology Department of Lanzhou Uni...
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| Veröffentlicht in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2024-10, Vol.31 (10), p.3095-3101 |
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| creator | Wang, Rong Ge, Yan Dong, Xianghua Wang, Haiping Wang, Liyan Gao, Mingxia |
| description | To retrospectively analyze the fertility outcomes and prognosis of gestational trophoblastic disease (GTD) patients, providing a basis for targeted fertility guidance and counseling. 82 GTD patients of childbearing age who received treatment at the Obstetrics and Gynecology Department of Lanzhou University First Hospital from January 2016 to January 2023 were stratified into re-pregnancy (
n
= 20) and non-re-pregnancy (
n
= 33) cohorts based on their pregnancy outcomes. The impacts of various factors on pregnancy outcomes were subsequently evaluated, encompassing the rates of subsequent pregnancies, live births, miscarriages, ectopic pregnancies, and ongoing pregnancies. Finally, logistics regression model was employed to analyze the risk factors affecting re-pregnancy in GTD patients. The study delineated those patients with different GTD pathologies had varying re-pregnancy rates (mole, erosive mole and choriocarcinoma accounted for 66.04%, 30.19% and 3.77%, respectively). Treatment predominantly involved uterine curettage, with fewer cases receiving chemotherapy alone or in conjunction with curettage accounted for 67.92%, 5.66%, and 26.42%, respectively. The average chemotherapy frequency was 4.59 ± 2.43 sessions, and a majority sought reproductive counseling. Re-pregnancy occurred in 37.74% of patients. The live birth rate was 65.00%, with miscarriage and ectopic pregnancy rates at 25.00% and 5.00% respectively. Logistic regression analysis pinpointed the absence of pre-pregnancy counseling as a significant independent risk factor for re-pregnancy in GTD patients (
p
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| doi_str_mv | 10.1007/s43032-024-01594-9 |
| format | Article |
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n
= 20) and non-re-pregnancy (
n
= 33) cohorts based on their pregnancy outcomes. The impacts of various factors on pregnancy outcomes were subsequently evaluated, encompassing the rates of subsequent pregnancies, live births, miscarriages, ectopic pregnancies, and ongoing pregnancies. Finally, logistics regression model was employed to analyze the risk factors affecting re-pregnancy in GTD patients. The study delineated those patients with different GTD pathologies had varying re-pregnancy rates (mole, erosive mole and choriocarcinoma accounted for 66.04%, 30.19% and 3.77%, respectively). Treatment predominantly involved uterine curettage, with fewer cases receiving chemotherapy alone or in conjunction with curettage accounted for 67.92%, 5.66%, and 26.42%, respectively. The average chemotherapy frequency was 4.59 ± 2.43 sessions, and a majority sought reproductive counseling. Re-pregnancy occurred in 37.74% of patients. The live birth rate was 65.00%, with miscarriage and ectopic pregnancy rates at 25.00% and 5.00% respectively. Logistic regression analysis pinpointed the absence of pre-pregnancy counseling as a significant independent risk factor for re-pregnancy in GTD patients (
p
< 0.05). While chemotherapy may influence ovarian function, with the majority of patients desiring children post-recovery, pregnancy rates remain high. Fertility counseling significantly enhances re-pregnancy success rates in GTD survivors, emphasizing its recommendation for those aiming to conceive post-recovery.</description><identifier>ISSN: 1933-7191</identifier><identifier>ISSN: 1933-7205</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1007/s43032-024-01594-9</identifier><identifier>PMID: 39026051</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Embryology ; Female ; Fertility ; Gestational Trophoblastic Disease - diagnosis ; Gestational Trophoblastic Disease - epidemiology ; Gestational Trophoblastic Disease - therapy ; Humans ; Infertility: Original Article ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Pregnancy ; Pregnancy Outcome ; Prognosis ; Reproductive Medicine ; Retrospective Studies ; Risk Factors ; Young Adult</subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2024-10, Vol.31 (10), p.3095-3101</ispartof><rights>The Author(s), under exclusive licence to Society for Reproductive Investigation 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Society for Reproductive Investigation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-1b3e593d2e52a57c8a00bf46b5d6b2c7936f9cc819ebd89aeeaa2ae28204fb573</cites><orcidid>0000-0003-0618-7868</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s43032-024-01594-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s43032-024-01594-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39026051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Rong</creatorcontrib><creatorcontrib>Ge, Yan</creatorcontrib><creatorcontrib>Dong, Xianghua</creatorcontrib><creatorcontrib>Wang, Haiping</creatorcontrib><creatorcontrib>Wang, Liyan</creatorcontrib><creatorcontrib>Gao, Mingxia</creatorcontrib><title>Analysis of Fertility Prognosis and Risk Factors in Patients Post-Gestational Trophoblastic Disease</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>To retrospectively analyze the fertility outcomes and prognosis of gestational trophoblastic disease (GTD) patients, providing a basis for targeted fertility guidance and counseling. 82 GTD patients of childbearing age who received treatment at the Obstetrics and Gynecology Department of Lanzhou University First Hospital from January 2016 to January 2023 were stratified into re-pregnancy (
n
= 20) and non-re-pregnancy (
n
= 33) cohorts based on their pregnancy outcomes. The impacts of various factors on pregnancy outcomes were subsequently evaluated, encompassing the rates of subsequent pregnancies, live births, miscarriages, ectopic pregnancies, and ongoing pregnancies. Finally, logistics regression model was employed to analyze the risk factors affecting re-pregnancy in GTD patients. The study delineated those patients with different GTD pathologies had varying re-pregnancy rates (mole, erosive mole and choriocarcinoma accounted for 66.04%, 30.19% and 3.77%, respectively). Treatment predominantly involved uterine curettage, with fewer cases receiving chemotherapy alone or in conjunction with curettage accounted for 67.92%, 5.66%, and 26.42%, respectively. The average chemotherapy frequency was 4.59 ± 2.43 sessions, and a majority sought reproductive counseling. Re-pregnancy occurred in 37.74% of patients. The live birth rate was 65.00%, with miscarriage and ectopic pregnancy rates at 25.00% and 5.00% respectively. Logistic regression analysis pinpointed the absence of pre-pregnancy counseling as a significant independent risk factor for re-pregnancy in GTD patients (
p
< 0.05). While chemotherapy may influence ovarian function, with the majority of patients desiring children post-recovery, pregnancy rates remain high. Fertility counseling significantly enhances re-pregnancy success rates in GTD survivors, emphasizing its recommendation for those aiming to conceive post-recovery.</description><subject>Adult</subject><subject>Embryology</subject><subject>Female</subject><subject>Fertility</subject><subject>Gestational Trophoblastic Disease - diagnosis</subject><subject>Gestational Trophoblastic Disease - epidemiology</subject><subject>Gestational Trophoblastic Disease - therapy</subject><subject>Humans</subject><subject>Infertility: Original Article</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prognosis</subject><subject>Reproductive Medicine</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>1933-7191</issn><issn>1933-7205</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P3DAQxS1UxL_yBXqofOwlYI_jJD4i2oVKSKwQPVuOM1lMs_HW4z3st6-XhR57mtGb955GP8a-SHElhWivqVZCQSWgroTUpq7METuTRqmqBaE_fezSyFN2TvQqhK4NdCfsVBkBjdDyjPmb2U07CsTjyBeYcphC3vFliqs57mU3D_wp0G--cD7HRDzMfOlywDkTX0bK1R1SLkIsRfw5xc1L7CdHOXj-PRA6ws_seHQT4eX7vGC_Fj-eb--rh8e7n7c3D5UH6HIle4XaqAFQg9Ot75wQ_Vg3vR6aHnxrVDMa7ztpsB864xCdA4fQgajHXrfqgn079G5S_LMtX9l1II_T5GaMW7JKdNBAyUOxwsHqUyRKONpNCmuXdlYKu4drD3BtgWvf4FpTQl_f-7f9God_kQ-axaAOBiqneYXJvsZtKlzof7V_AUajhm4</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Wang, Rong</creator><creator>Ge, Yan</creator><creator>Dong, Xianghua</creator><creator>Wang, Haiping</creator><creator>Wang, Liyan</creator><creator>Gao, Mingxia</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0618-7868</orcidid></search><sort><creationdate>20241001</creationdate><title>Analysis of Fertility Prognosis and Risk Factors in Patients Post-Gestational Trophoblastic Disease</title><author>Wang, Rong ; Ge, Yan ; Dong, Xianghua ; Wang, Haiping ; Wang, Liyan ; Gao, Mingxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-1b3e593d2e52a57c8a00bf46b5d6b2c7936f9cc819ebd89aeeaa2ae28204fb573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Embryology</topic><topic>Female</topic><topic>Fertility</topic><topic>Gestational Trophoblastic Disease - diagnosis</topic><topic>Gestational Trophoblastic Disease - epidemiology</topic><topic>Gestational Trophoblastic Disease - therapy</topic><topic>Humans</topic><topic>Infertility: Original Article</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prognosis</topic><topic>Reproductive Medicine</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Rong</creatorcontrib><creatorcontrib>Ge, Yan</creatorcontrib><creatorcontrib>Dong, Xianghua</creatorcontrib><creatorcontrib>Wang, Haiping</creatorcontrib><creatorcontrib>Wang, Liyan</creatorcontrib><creatorcontrib>Gao, Mingxia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Rong</au><au>Ge, Yan</au><au>Dong, Xianghua</au><au>Wang, Haiping</au><au>Wang, Liyan</au><au>Gao, Mingxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Fertility Prognosis and Risk Factors in Patients Post-Gestational Trophoblastic Disease</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>31</volume><issue>10</issue><spage>3095</spage><epage>3101</epage><pages>3095-3101</pages><issn>1933-7191</issn><issn>1933-7205</issn><eissn>1933-7205</eissn><abstract>To retrospectively analyze the fertility outcomes and prognosis of gestational trophoblastic disease (GTD) patients, providing a basis for targeted fertility guidance and counseling. 82 GTD patients of childbearing age who received treatment at the Obstetrics and Gynecology Department of Lanzhou University First Hospital from January 2016 to January 2023 were stratified into re-pregnancy (
n
= 20) and non-re-pregnancy (
n
= 33) cohorts based on their pregnancy outcomes. The impacts of various factors on pregnancy outcomes were subsequently evaluated, encompassing the rates of subsequent pregnancies, live births, miscarriages, ectopic pregnancies, and ongoing pregnancies. Finally, logistics regression model was employed to analyze the risk factors affecting re-pregnancy in GTD patients. The study delineated those patients with different GTD pathologies had varying re-pregnancy rates (mole, erosive mole and choriocarcinoma accounted for 66.04%, 30.19% and 3.77%, respectively). Treatment predominantly involved uterine curettage, with fewer cases receiving chemotherapy alone or in conjunction with curettage accounted for 67.92%, 5.66%, and 26.42%, respectively. The average chemotherapy frequency was 4.59 ± 2.43 sessions, and a majority sought reproductive counseling. Re-pregnancy occurred in 37.74% of patients. The live birth rate was 65.00%, with miscarriage and ectopic pregnancy rates at 25.00% and 5.00% respectively. Logistic regression analysis pinpointed the absence of pre-pregnancy counseling as a significant independent risk factor for re-pregnancy in GTD patients (
p
< 0.05). While chemotherapy may influence ovarian function, with the majority of patients desiring children post-recovery, pregnancy rates remain high. Fertility counseling significantly enhances re-pregnancy success rates in GTD survivors, emphasizing its recommendation for those aiming to conceive post-recovery.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>39026051</pmid><doi>10.1007/s43032-024-01594-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0618-7868</orcidid></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Embryology Female Fertility Gestational Trophoblastic Disease - diagnosis Gestational Trophoblastic Disease - epidemiology Gestational Trophoblastic Disease - therapy Humans Infertility: Original Article Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Pregnancy Pregnancy Outcome Prognosis Reproductive Medicine Retrospective Studies Risk Factors Young Adult |
| title | Analysis of Fertility Prognosis and Risk Factors in Patients Post-Gestational Trophoblastic Disease |
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