Posttraumatic epilepsy: Integrating clinical, inflammatory, and genetic profiles in traumatic brain injury patients
This study aims to assess the clinical, inflammatory, and genetic profiles of traumatic brain injury (TBI) patients over a 2-year follow-up period, focusing on the development of posttraumatic epilepsy (PTE). Fifty-nine patients with acute TBI were recruited in the emergency unit of a hospital in Br...
Gespeichert in:
| Veröffentlicht in: | Epilepsy research 2024-09, Vol.205, p.107402, Article 107402 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 107402 |
| container_title | Epilepsy research |
| container_volume | 205 |
| creator | Mosini, Amanda C. Sanabria, Viviam Nakamura, Thábatta K.E. Calió, Michele L. Pompeu, Clara Silva, Clivandir S. Nicolicht-Amorim, Priscila da Graça Naffah-Mazzacoratti, Maria Porcionatto, Marimelia A. Mello, Luiz Eugênio Foresti, Maira L. |
| description | This study aims to assess the clinical, inflammatory, and genetic profiles of traumatic brain injury (TBI) patients over a 2-year follow-up period, focusing on the development of posttraumatic epilepsy (PTE).
Fifty-nine patients with acute TBI were recruited in the emergency unit of a hospital in Brazil. Clinical data and blood samples were collected after 10 days of hospitalization for posterior genetic profile (Apolipoprotein E- ApoE and Glutamic Acid Descarboxylase-GAD sequencing) analyses. A subset of 19 patients were assessed for cytokine markers (mRNA expression). The development of PTE was investigated for two years following TBI. Statistical analyses including univariate analysis, multiple correspondence analysis, and Mann-Whitney test were performed.
Analysis revealed an association between severe TBI and requirement for neurosurgery and polytrauma (p |
| doi_str_mv | 10.1016/j.eplepsyres.2024.107402 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3082627644</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0920121124001177</els_id><sourcerecordid>3082627644</sourcerecordid><originalsourceid>FETCH-LOGICAL-c249t-d84cc6cd15cfea4001fa2c20ca3fc47bd94ca9ecad8d43a089fb5f20f34b368a3</originalsourceid><addsrcrecordid>eNqFkMFu1DAQhi1ERbeFV0A-cmiWseMmDjeooFSqRA_t2XLG45VXiRPsBGnfHi9b6JGT5dH3_2N_jHEBWwGi-bjf0jzQnA-J8laCVGXcKpCv2EboVlaNVuo120AnoRJSiHN2kfMeAFpQ6g07r7uS0bXcsPww5WVJdh3tEpDTHP70fuJ3caFdKsO44ziEGNAOVzxEP9ixsFM6XHEbHd9RpGNyTpMv2VwQ_tLXJ1vuIe7XdOBzGVFc8lt25u2Q6d3zecmevn19vPle3f-4vbv5fF-hVN1SOa0QG3TiGj1ZBSC8lSgBbe1Rtb3rFNqO0DrtVG1Bd76_9hJ8rfq60ba-ZB9OveVtP1fKixlDRhoGG2las6lBy0a2jVIF1ScU05RzIm_mFEabDkaAOSo3e_Oi3ByVm5PyEn3_vGXtR3L_gn8dF-DLCaDy11-BkslYPCC5kAgX46bw_y2_Ae0Lm7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3082627644</pqid></control><display><type>article</type><title>Posttraumatic epilepsy: Integrating clinical, inflammatory, and genetic profiles in traumatic brain injury patients</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Mosini, Amanda C. ; Sanabria, Viviam ; Nakamura, Thábatta K.E. ; Calió, Michele L. ; Pompeu, Clara ; Silva, Clivandir S. ; Nicolicht-Amorim, Priscila ; da Graça Naffah-Mazzacoratti, Maria ; Porcionatto, Marimelia A. ; Mello, Luiz Eugênio ; Foresti, Maira L.</creator><creatorcontrib>Mosini, Amanda C. ; Sanabria, Viviam ; Nakamura, Thábatta K.E. ; Calió, Michele L. ; Pompeu, Clara ; Silva, Clivandir S. ; Nicolicht-Amorim, Priscila ; da Graça Naffah-Mazzacoratti, Maria ; Porcionatto, Marimelia A. ; Mello, Luiz Eugênio ; Foresti, Maira L.</creatorcontrib><description>This study aims to assess the clinical, inflammatory, and genetic profiles of traumatic brain injury (TBI) patients over a 2-year follow-up period, focusing on the development of posttraumatic epilepsy (PTE).
Fifty-nine patients with acute TBI were recruited in the emergency unit of a hospital in Brazil. Clinical data and blood samples were collected after 10 days of hospitalization for posterior genetic profile (Apolipoprotein E- ApoE and Glutamic Acid Descarboxylase-GAD sequencing) analyses. A subset of 19 patients were assessed for cytokine markers (mRNA expression). The development of PTE was investigated for two years following TBI. Statistical analyses including univariate analysis, multiple correspondence analysis, and Mann-Whitney test were performed.
Analysis revealed an association between severe TBI and requirement for neurosurgery and polytrauma (p<0.05), as well as the development of PTE over a two-year follow-up period (p<0.05). Multiple correspondence analysis identified two distinct profiles associated with PTE and Non-PTE outcomes. The PTE profile showed a higher prevalence of the ApoE genotype E3/E3 and GAD1 SNP (rs769391) genotype AA in our study, while the Non-PTE profile showed a higher presence of E3/E4. mRNA expression analysis demonstrated acute elevated levels of TNF-α in the PTE group as compared to Non-PTE patients (6.70±1.53 vs 5.31 ±0.33, p<0.01).
Our findings underscore the multifactorial nature of aspects potentially contributing to PTE. It is unlikely that any single factor might in isolation have a strong causative influence over the development of epilepsy after TBI. Our results provide a suggestion of potential clustering that might be relevant as prognostic factors for PTE.
•PTE profile was characterized by severe TBI, hematomas, bilateral lesions, and a higher likelihood of neurosurgery.•Elevated TNF-α mRNA expression was observed in patients with moderate and severe TBI.•Specific clinical factors may predispose individuals to developing PTE following acute TBI.</description><identifier>ISSN: 0920-1211</identifier><identifier>ISSN: 1872-6844</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/j.eplepsyres.2024.107402</identifier><identifier>PMID: 39024832</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Apolipoprotein E ; Epileptogenesis ; Glutamic acid decarboxylase, TNF-α ; Neuroinflammation</subject><ispartof>Epilepsy research, 2024-09, Vol.205, p.107402, Article 107402</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c249t-d84cc6cd15cfea4001fa2c20ca3fc47bd94ca9ecad8d43a089fb5f20f34b368a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.eplepsyres.2024.107402$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39024832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mosini, Amanda C.</creatorcontrib><creatorcontrib>Sanabria, Viviam</creatorcontrib><creatorcontrib>Nakamura, Thábatta K.E.</creatorcontrib><creatorcontrib>Calió, Michele L.</creatorcontrib><creatorcontrib>Pompeu, Clara</creatorcontrib><creatorcontrib>Silva, Clivandir S.</creatorcontrib><creatorcontrib>Nicolicht-Amorim, Priscila</creatorcontrib><creatorcontrib>da Graça Naffah-Mazzacoratti, Maria</creatorcontrib><creatorcontrib>Porcionatto, Marimelia A.</creatorcontrib><creatorcontrib>Mello, Luiz Eugênio</creatorcontrib><creatorcontrib>Foresti, Maira L.</creatorcontrib><title>Posttraumatic epilepsy: Integrating clinical, inflammatory, and genetic profiles in traumatic brain injury patients</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>This study aims to assess the clinical, inflammatory, and genetic profiles of traumatic brain injury (TBI) patients over a 2-year follow-up period, focusing on the development of posttraumatic epilepsy (PTE).
Fifty-nine patients with acute TBI were recruited in the emergency unit of a hospital in Brazil. Clinical data and blood samples were collected after 10 days of hospitalization for posterior genetic profile (Apolipoprotein E- ApoE and Glutamic Acid Descarboxylase-GAD sequencing) analyses. A subset of 19 patients were assessed for cytokine markers (mRNA expression). The development of PTE was investigated for two years following TBI. Statistical analyses including univariate analysis, multiple correspondence analysis, and Mann-Whitney test were performed.
Analysis revealed an association between severe TBI and requirement for neurosurgery and polytrauma (p<0.05), as well as the development of PTE over a two-year follow-up period (p<0.05). Multiple correspondence analysis identified two distinct profiles associated with PTE and Non-PTE outcomes. The PTE profile showed a higher prevalence of the ApoE genotype E3/E3 and GAD1 SNP (rs769391) genotype AA in our study, while the Non-PTE profile showed a higher presence of E3/E4. mRNA expression analysis demonstrated acute elevated levels of TNF-α in the PTE group as compared to Non-PTE patients (6.70±1.53 vs 5.31 ±0.33, p<0.01).
Our findings underscore the multifactorial nature of aspects potentially contributing to PTE. It is unlikely that any single factor might in isolation have a strong causative influence over the development of epilepsy after TBI. Our results provide a suggestion of potential clustering that might be relevant as prognostic factors for PTE.
•PTE profile was characterized by severe TBI, hematomas, bilateral lesions, and a higher likelihood of neurosurgery.•Elevated TNF-α mRNA expression was observed in patients with moderate and severe TBI.•Specific clinical factors may predispose individuals to developing PTE following acute TBI.</description><subject>Apolipoprotein E</subject><subject>Epileptogenesis</subject><subject>Glutamic acid decarboxylase, TNF-α</subject><subject>Neuroinflammation</subject><issn>0920-1211</issn><issn>1872-6844</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkMFu1DAQhi1ERbeFV0A-cmiWseMmDjeooFSqRA_t2XLG45VXiRPsBGnfHi9b6JGT5dH3_2N_jHEBWwGi-bjf0jzQnA-J8laCVGXcKpCv2EboVlaNVuo120AnoRJSiHN2kfMeAFpQ6g07r7uS0bXcsPww5WVJdh3tEpDTHP70fuJ3caFdKsO44ziEGNAOVzxEP9ixsFM6XHEbHd9RpGNyTpMv2VwQ_tLXJ1vuIe7XdOBzGVFc8lt25u2Q6d3zecmevn19vPle3f-4vbv5fF-hVN1SOa0QG3TiGj1ZBSC8lSgBbe1Rtb3rFNqO0DrtVG1Bd76_9hJ8rfq60ba-ZB9OveVtP1fKixlDRhoGG2las6lBy0a2jVIF1ScU05RzIm_mFEabDkaAOSo3e_Oi3ByVm5PyEn3_vGXtR3L_gn8dF-DLCaDy11-BkslYPCC5kAgX46bw_y2_Ae0Lm7w</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Mosini, Amanda C.</creator><creator>Sanabria, Viviam</creator><creator>Nakamura, Thábatta K.E.</creator><creator>Calió, Michele L.</creator><creator>Pompeu, Clara</creator><creator>Silva, Clivandir S.</creator><creator>Nicolicht-Amorim, Priscila</creator><creator>da Graça Naffah-Mazzacoratti, Maria</creator><creator>Porcionatto, Marimelia A.</creator><creator>Mello, Luiz Eugênio</creator><creator>Foresti, Maira L.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240901</creationdate><title>Posttraumatic epilepsy: Integrating clinical, inflammatory, and genetic profiles in traumatic brain injury patients</title><author>Mosini, Amanda C. ; Sanabria, Viviam ; Nakamura, Thábatta K.E. ; Calió, Michele L. ; Pompeu, Clara ; Silva, Clivandir S. ; Nicolicht-Amorim, Priscila ; da Graça Naffah-Mazzacoratti, Maria ; Porcionatto, Marimelia A. ; Mello, Luiz Eugênio ; Foresti, Maira L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c249t-d84cc6cd15cfea4001fa2c20ca3fc47bd94ca9ecad8d43a089fb5f20f34b368a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Apolipoprotein E</topic><topic>Epileptogenesis</topic><topic>Glutamic acid decarboxylase, TNF-α</topic><topic>Neuroinflammation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mosini, Amanda C.</creatorcontrib><creatorcontrib>Sanabria, Viviam</creatorcontrib><creatorcontrib>Nakamura, Thábatta K.E.</creatorcontrib><creatorcontrib>Calió, Michele L.</creatorcontrib><creatorcontrib>Pompeu, Clara</creatorcontrib><creatorcontrib>Silva, Clivandir S.</creatorcontrib><creatorcontrib>Nicolicht-Amorim, Priscila</creatorcontrib><creatorcontrib>da Graça Naffah-Mazzacoratti, Maria</creatorcontrib><creatorcontrib>Porcionatto, Marimelia A.</creatorcontrib><creatorcontrib>Mello, Luiz Eugênio</creatorcontrib><creatorcontrib>Foresti, Maira L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mosini, Amanda C.</au><au>Sanabria, Viviam</au><au>Nakamura, Thábatta K.E.</au><au>Calió, Michele L.</au><au>Pompeu, Clara</au><au>Silva, Clivandir S.</au><au>Nicolicht-Amorim, Priscila</au><au>da Graça Naffah-Mazzacoratti, Maria</au><au>Porcionatto, Marimelia A.</au><au>Mello, Luiz Eugênio</au><au>Foresti, Maira L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posttraumatic epilepsy: Integrating clinical, inflammatory, and genetic profiles in traumatic brain injury patients</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>205</volume><spage>107402</spage><pages>107402-</pages><artnum>107402</artnum><issn>0920-1211</issn><issn>1872-6844</issn><eissn>1872-6844</eissn><abstract>This study aims to assess the clinical, inflammatory, and genetic profiles of traumatic brain injury (TBI) patients over a 2-year follow-up period, focusing on the development of posttraumatic epilepsy (PTE).
Fifty-nine patients with acute TBI were recruited in the emergency unit of a hospital in Brazil. Clinical data and blood samples were collected after 10 days of hospitalization for posterior genetic profile (Apolipoprotein E- ApoE and Glutamic Acid Descarboxylase-GAD sequencing) analyses. A subset of 19 patients were assessed for cytokine markers (mRNA expression). The development of PTE was investigated for two years following TBI. Statistical analyses including univariate analysis, multiple correspondence analysis, and Mann-Whitney test were performed.
Analysis revealed an association between severe TBI and requirement for neurosurgery and polytrauma (p<0.05), as well as the development of PTE over a two-year follow-up period (p<0.05). Multiple correspondence analysis identified two distinct profiles associated with PTE and Non-PTE outcomes. The PTE profile showed a higher prevalence of the ApoE genotype E3/E3 and GAD1 SNP (rs769391) genotype AA in our study, while the Non-PTE profile showed a higher presence of E3/E4. mRNA expression analysis demonstrated acute elevated levels of TNF-α in the PTE group as compared to Non-PTE patients (6.70±1.53 vs 5.31 ±0.33, p<0.01).
Our findings underscore the multifactorial nature of aspects potentially contributing to PTE. It is unlikely that any single factor might in isolation have a strong causative influence over the development of epilepsy after TBI. Our results provide a suggestion of potential clustering that might be relevant as prognostic factors for PTE.
•PTE profile was characterized by severe TBI, hematomas, bilateral lesions, and a higher likelihood of neurosurgery.•Elevated TNF-α mRNA expression was observed in patients with moderate and severe TBI.•Specific clinical factors may predispose individuals to developing PTE following acute TBI.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39024832</pmid><doi>10.1016/j.eplepsyres.2024.107402</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-1211 |
| ispartof | Epilepsy research, 2024-09, Vol.205, p.107402, Article 107402 |
| issn | 0920-1211 1872-6844 1872-6844 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3082627644 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Apolipoprotein E Epileptogenesis Glutamic acid decarboxylase, TNF-α Neuroinflammation |
| title | Posttraumatic epilepsy: Integrating clinical, inflammatory, and genetic profiles in traumatic brain injury patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T17%3A21%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Posttraumatic%20epilepsy:%20Integrating%20clinical,%20inflammatory,%20and%20genetic%20profiles%20in%20traumatic%20brain%20injury%20patients&rft.jtitle=Epilepsy%20research&rft.au=Mosini,%20Amanda%20C.&rft.date=2024-09-01&rft.volume=205&rft.spage=107402&rft.pages=107402-&rft.artnum=107402&rft.issn=0920-1211&rft.eissn=1872-6844&rft_id=info:doi/10.1016/j.eplepsyres.2024.107402&rft_dat=%3Cproquest_cross%3E3082627644%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3082627644&rft_id=info:pmid/39024832&rft_els_id=S0920121124001177&rfr_iscdi=true |