Effect and mechanism of Jinkui Shenqi Pill on preventing neural tube defects in mice based on network pharmacology

jinkui Shenqi Pill (JSP) is a classic traditional Chinese medicine used to treat “Kidney Yang Deficiency” disease. Previous studies indicate a protective effect of JSP on apoptosis in mouse neurons. This research, combining network pharmacology with in vivo experiments, explores the mechanism of JSP...

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Veröffentlicht in:	Journal of ethnopharmacology 2024-11, Vol.334, p.118587, Article 118587
Hauptverfasser:	Xie, Liangqi, Hu, Min, Gan, Yingying, Ru, Yi, Xiao, Baoguo, Jin, Xiaoming, Ma, Cungen, Chai, Zhi, Fan, Huijie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell apoptosis Disease Models, Animal Drugs, Chinese Herbal - pharmacology Female Jinkui Shenqi Pill Mice Molecular Docking Simulation Network Pharmacology Neural tube defects Neural Tube Defects - chemically induced Neural Tube Defects - prevention & control Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol-3-kinase/protein kinase B signaling pathway Pregnancy Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Tretinoin - pharmacology
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