Prognostic impact of the high-sensitivity modified glasgow prognostic score on patients undergoing radical surgery for hepatocellular carcinoma: Authorship
Objective Our study aimed to assess the ability of high-sensitivity modified Glasgow prognostic Score (HS-mGPS) predicting survival in patients undergoing radical surgery for hepatocellular carcinoma (HCC) and to compare the impact with other Inflammation-Based prognostic scoring systems including G...
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| creator | Luo, Baoyang Zhang, Yun Zhu, Xi Ji, Tianhao Wu, Kejia Sun, Donglin Lu, Yunjie Shi, Longqing |
| description | Objective
Our study aimed to assess the ability of high-sensitivity modified Glasgow prognostic Score (HS-mGPS) predicting survival in patients undergoing radical surgery for hepatocellular carcinoma (HCC) and to compare the impact with other Inflammation-Based prognostic scoring systems including Glasgow prognostic Score (GPS) and modified GPS (mGPS).
Methods
Our study evaluated 293 patients with HCC who had undergone hepatectomy at the Third Affiliated Hospital of Soochow University between 2010 and 2018. The HS-mGPS, mGPS, and GPS were calculated based on particular cut-off values of preoperative C-reactive protein and albumin, and the correlations between HS-mGPS and clinicopathological parameters were evaluated. Univariate and multivariate survival analyses were conducted by Kaplan–Meier method and Cox proportional hazards model. To evaluate the discrimination ability of each prognostic score, the receiver operating characteristic (ROC) curve were generated and the areas under the curve (AUC) were measured and compared.
Result
The study results indicated a correlation between elevated HS-mGPS scores and adverse clinical factors, including higher BCLC stage, C-P grade, multiple tumors, and larger tumor diameter. Kaplan-Meier and univariate survival analyses revealed that higher scores of HS-mGPS, GPS, and mGPS were all associated with significantly reduced overall survival (OS) (all
p
|
| doi_str_mv | 10.1007/s00423-024-03423-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3082311621</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3082311621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1438-4452a6ecae879513b9c298991f63679142cb2e7f87c4bace92fa2f7ae1e781ec3</originalsourceid><addsrcrecordid>eNp9kclu3DAQRInARsbbD-QQ8OiLHG7ajoERL4CB-GCfCQ7V1HAgkRO2lGC-Ir9sjuUsJ5_YAF8VuroI-cTZFWes_oKMKSELJlTB5GFqPpATrmRZCFXyo__mFTlF3DLGqrpVH8lKtkzIquQn5Pdjin2IOHlL_bgzdqLR0WkDdOP7TYEQ0E_-p5_2dIyddx462g8G-_iL7v5J0cYENAa6M5OHMCGdQwepjz70NJnOWzNQnFMPaU9dTHQDmYwWhmEeTKLWJOtDHM05OXZmQLh4e8_I8823p-u74uH77f3114fC5lBNoVQpTAXWQFO3JZfr1oq2aVvuKpkzciXsWkDtmtqqtbHQCmeEqw1wqBsOVp6Ry8U3h_gxA0569HhYxwSIM2rJGiE5rwTPqFhQmyJiAqd3yY8m7TVn-lCEXorQuQj9WoRusujzm_-8HqH7K_lz-QzIBcD8FfJd9DbOKeTM79m-AGVvl50</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3082311621</pqid></control><display><type>article</type><title>Prognostic impact of the high-sensitivity modified glasgow prognostic score on patients undergoing radical surgery for hepatocellular carcinoma: Authorship</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Luo, Baoyang ; Zhang, Yun ; Zhu, Xi ; Ji, Tianhao ; Wu, Kejia ; Sun, Donglin ; Lu, Yunjie ; Shi, Longqing</creator><creatorcontrib>Luo, Baoyang ; Zhang, Yun ; Zhu, Xi ; Ji, Tianhao ; Wu, Kejia ; Sun, Donglin ; Lu, Yunjie ; Shi, Longqing</creatorcontrib><description>Objective
Our study aimed to assess the ability of high-sensitivity modified Glasgow prognostic Score (HS-mGPS) predicting survival in patients undergoing radical surgery for hepatocellular carcinoma (HCC) and to compare the impact with other Inflammation-Based prognostic scoring systems including Glasgow prognostic Score (GPS) and modified GPS (mGPS).
Methods
Our study evaluated 293 patients with HCC who had undergone hepatectomy at the Third Affiliated Hospital of Soochow University between 2010 and 2018. The HS-mGPS, mGPS, and GPS were calculated based on particular cut-off values of preoperative C-reactive protein and albumin, and the correlations between HS-mGPS and clinicopathological parameters were evaluated. Univariate and multivariate survival analyses were conducted by Kaplan–Meier method and Cox proportional hazards model. To evaluate the discrimination ability of each prognostic score, the receiver operating characteristic (ROC) curve were generated and the areas under the curve (AUC) were measured and compared.
Result
The study results indicated a correlation between elevated HS-mGPS scores and adverse clinical factors, including higher BCLC stage, C-P grade, multiple tumors, and larger tumor diameter. Kaplan-Meier and univariate survival analyses revealed that higher scores of HS-mGPS, GPS, and mGPS were all associated with significantly reduced overall survival (OS) (all
p
< 0.001). In multivariate survival analysis, HS-mGPS emerged as an independent risk factor for poor OS in patients undergoing hepatectomy for HCC (
p
= 0.010), along with factors including maximal tumor diameter (
p
< 0.001), microvascular invasion (MVI) (
p
= 0.008), and BCLC stage (
p
= 0.001). The analysis of ROC curves and the AUC values indicated that HS-mGPS outperforms GPS and mGPS in predicting the long-term prognosis of patients with resectable HCC.
Conclusion
Preoperative HS-mGPS proves superior in predicting adverse long-term outcomes in HCC patients undergoing radical surgery.</description><identifier>ISSN: 1435-2451</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-024-03423-8</identifier><identifier>PMID: 39023651</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Adult ; Aged ; C-Reactive Protein - analysis ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Cardiac Surgery ; Female ; General Surgery ; Hepatectomy ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms - blood ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2024-07, Vol.409 (1), p.223, Article 223</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1438-4452a6ecae879513b9c298991f63679142cb2e7f87c4bace92fa2f7ae1e781ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-024-03423-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-024-03423-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39023651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Baoyang</creatorcontrib><creatorcontrib>Zhang, Yun</creatorcontrib><creatorcontrib>Zhu, Xi</creatorcontrib><creatorcontrib>Ji, Tianhao</creatorcontrib><creatorcontrib>Wu, Kejia</creatorcontrib><creatorcontrib>Sun, Donglin</creatorcontrib><creatorcontrib>Lu, Yunjie</creatorcontrib><creatorcontrib>Shi, Longqing</creatorcontrib><title>Prognostic impact of the high-sensitivity modified glasgow prognostic score on patients undergoing radical surgery for hepatocellular carcinoma: Authorship</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Objective
Our study aimed to assess the ability of high-sensitivity modified Glasgow prognostic Score (HS-mGPS) predicting survival in patients undergoing radical surgery for hepatocellular carcinoma (HCC) and to compare the impact with other Inflammation-Based prognostic scoring systems including Glasgow prognostic Score (GPS) and modified GPS (mGPS).
Methods
Our study evaluated 293 patients with HCC who had undergone hepatectomy at the Third Affiliated Hospital of Soochow University between 2010 and 2018. The HS-mGPS, mGPS, and GPS were calculated based on particular cut-off values of preoperative C-reactive protein and albumin, and the correlations between HS-mGPS and clinicopathological parameters were evaluated. Univariate and multivariate survival analyses were conducted by Kaplan–Meier method and Cox proportional hazards model. To evaluate the discrimination ability of each prognostic score, the receiver operating characteristic (ROC) curve were generated and the areas under the curve (AUC) were measured and compared.
Result
The study results indicated a correlation between elevated HS-mGPS scores and adverse clinical factors, including higher BCLC stage, C-P grade, multiple tumors, and larger tumor diameter. Kaplan-Meier and univariate survival analyses revealed that higher scores of HS-mGPS, GPS, and mGPS were all associated with significantly reduced overall survival (OS) (all
p
< 0.001). In multivariate survival analysis, HS-mGPS emerged as an independent risk factor for poor OS in patients undergoing hepatectomy for HCC (
p
= 0.010), along with factors including maximal tumor diameter (
p
< 0.001), microvascular invasion (MVI) (
p
= 0.008), and BCLC stage (
p
= 0.001). The analysis of ROC curves and the AUC values indicated that HS-mGPS outperforms GPS and mGPS in predicting the long-term prognosis of patients with resectable HCC.
Conclusion
Preoperative HS-mGPS proves superior in predicting adverse long-term outcomes in HCC patients undergoing radical surgery.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>C-Reactive Protein - analysis</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cardiac Surgery</subject><subject>Female</subject><subject>General Surgery</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2451</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kclu3DAQRInARsbbD-QQ8OiLHG7ajoERL4CB-GCfCQ7V1HAgkRO2lGC-Ir9sjuUsJ5_YAF8VuroI-cTZFWes_oKMKSELJlTB5GFqPpATrmRZCFXyo__mFTlF3DLGqrpVH8lKtkzIquQn5Pdjin2IOHlL_bgzdqLR0WkDdOP7TYEQ0E_-p5_2dIyddx462g8G-_iL7v5J0cYENAa6M5OHMCGdQwepjz70NJnOWzNQnFMPaU9dTHQDmYwWhmEeTKLWJOtDHM05OXZmQLh4e8_I8823p-u74uH77f3114fC5lBNoVQpTAXWQFO3JZfr1oq2aVvuKpkzciXsWkDtmtqqtbHQCmeEqw1wqBsOVp6Ry8U3h_gxA0569HhYxwSIM2rJGiE5rwTPqFhQmyJiAqd3yY8m7TVn-lCEXorQuQj9WoRusujzm_-8HqH7K_lz-QzIBcD8FfJd9DbOKeTM79m-AGVvl50</recordid><startdate>20240718</startdate><enddate>20240718</enddate><creator>Luo, Baoyang</creator><creator>Zhang, Yun</creator><creator>Zhu, Xi</creator><creator>Ji, Tianhao</creator><creator>Wu, Kejia</creator><creator>Sun, Donglin</creator><creator>Lu, Yunjie</creator><creator>Shi, Longqing</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240718</creationdate><title>Prognostic impact of the high-sensitivity modified glasgow prognostic score on patients undergoing radical surgery for hepatocellular carcinoma</title><author>Luo, Baoyang ; Zhang, Yun ; Zhu, Xi ; Ji, Tianhao ; Wu, Kejia ; Sun, Donglin ; Lu, Yunjie ; Shi, Longqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1438-4452a6ecae879513b9c298991f63679142cb2e7f87c4bace92fa2f7ae1e781ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>C-Reactive Protein - analysis</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cardiac Surgery</topic><topic>Female</topic><topic>General Surgery</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Baoyang</creatorcontrib><creatorcontrib>Zhang, Yun</creatorcontrib><creatorcontrib>Zhu, Xi</creatorcontrib><creatorcontrib>Ji, Tianhao</creatorcontrib><creatorcontrib>Wu, Kejia</creatorcontrib><creatorcontrib>Sun, Donglin</creatorcontrib><creatorcontrib>Lu, Yunjie</creatorcontrib><creatorcontrib>Shi, Longqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Baoyang</au><au>Zhang, Yun</au><au>Zhu, Xi</au><au>Ji, Tianhao</au><au>Wu, Kejia</au><au>Sun, Donglin</au><au>Lu, Yunjie</au><au>Shi, Longqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic impact of the high-sensitivity modified glasgow prognostic score on patients undergoing radical surgery for hepatocellular carcinoma: Authorship</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2024-07-18</date><risdate>2024</risdate><volume>409</volume><issue>1</issue><spage>223</spage><pages>223-</pages><artnum>223</artnum><issn>1435-2451</issn><eissn>1435-2451</eissn><abstract>Objective
Our study aimed to assess the ability of high-sensitivity modified Glasgow prognostic Score (HS-mGPS) predicting survival in patients undergoing radical surgery for hepatocellular carcinoma (HCC) and to compare the impact with other Inflammation-Based prognostic scoring systems including Glasgow prognostic Score (GPS) and modified GPS (mGPS).
Methods
Our study evaluated 293 patients with HCC who had undergone hepatectomy at the Third Affiliated Hospital of Soochow University between 2010 and 2018. The HS-mGPS, mGPS, and GPS were calculated based on particular cut-off values of preoperative C-reactive protein and albumin, and the correlations between HS-mGPS and clinicopathological parameters were evaluated. Univariate and multivariate survival analyses were conducted by Kaplan–Meier method and Cox proportional hazards model. To evaluate the discrimination ability of each prognostic score, the receiver operating characteristic (ROC) curve were generated and the areas under the curve (AUC) were measured and compared.
Result
The study results indicated a correlation between elevated HS-mGPS scores and adverse clinical factors, including higher BCLC stage, C-P grade, multiple tumors, and larger tumor diameter. Kaplan-Meier and univariate survival analyses revealed that higher scores of HS-mGPS, GPS, and mGPS were all associated with significantly reduced overall survival (OS) (all
p
< 0.001). In multivariate survival analysis, HS-mGPS emerged as an independent risk factor for poor OS in patients undergoing hepatectomy for HCC (
p
= 0.010), along with factors including maximal tumor diameter (
p
< 0.001), microvascular invasion (MVI) (
p
= 0.008), and BCLC stage (
p
= 0.001). The analysis of ROC curves and the AUC values indicated that HS-mGPS outperforms GPS and mGPS in predicting the long-term prognosis of patients with resectable HCC.
Conclusion
Preoperative HS-mGPS proves superior in predicting adverse long-term outcomes in HCC patients undergoing radical surgery.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39023651</pmid><doi>10.1007/s00423-024-03423-8</doi></addata></record> |
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| subjects | Abdominal Surgery Adult Aged C-Reactive Protein - analysis Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cardiac Surgery Female General Surgery Hepatectomy Humans Kaplan-Meier Estimate Liver Neoplasms - blood Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Prognosis Retrospective Studies Survival Rate Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Prognostic impact of the high-sensitivity modified glasgow prognostic score on patients undergoing radical surgery for hepatocellular carcinoma: Authorship |
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