Tubulin code eraser CCP5 binds branch glutamates by substrate deformation

Microtubule function is modulated by the tubulin code, diverse posttranslational modifications that are altered dynamically by writer and eraser enzymes 1 . Glutamylation—the addition of branched (isopeptide-linked) glutamate chains—is the most evolutionarily widespread tubulin modification 2 . It i...

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Veröffentlicht in:	Nature (London) 2024-07, Vol.631 (8022), p.905-912
Hauptverfasser:	Chen, Jiayi, Zehr, Elena A., Gruschus, James M., Szyk, Agnieszka, Liu, Yanjie, Tanner, Martin E., Tjandra, Nico, Roll-Mecak, Antonina
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 101/58 132/124 14/34 14/35 631/45/2783 631/535/1266 82 82/16 82/6 82/80 82/83 96 96/63 Carboxypeptidase Chain branching Crystal structure Crystallography Deformation Electron microscopy Enzymes Glutamates Homeostasis Humanities and Social Sciences Isotypes Microscopy multidisciplinary Mutation NMR Nuclear magnetic resonance Peptides Recognition Science Science (multidisciplinary) Substrates Tubulin Tyrosine
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