Focal pharmacological manipulation of serotonin signaling in the amygdala does not alter social behavior

Highlights Amygdala is proposed as site of action for serotonin drugs ameliorating anxiety. Contrary to this, intra-amygdala infusion of SSRIs did not affect social behavior. Similarly, 5-HT 1A , 5-HT 2A , and 5-HT 3 agonism/antagonism in amygdala had no effect. Thus, serotonin effects on social beh...

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Veröffentlicht in:	Psychopharmacology 2025, Vol.242 (1), p.101-115
Hauptverfasser:	Jacobs, Jessica T., Maior, Rafael S., Waguespack, Hannah F., Campos-Rodriguez, Carolina, Malkova, Ludise, Forcelli, Patrick A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Amygdala Amygdala - drug effects Amygdala - metabolism Animals Basolateral Nuclear Complex - drug effects Basolateral Nuclear Complex - metabolism Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Central Amygdaloid Nucleus - drug effects Central Amygdaloid Nucleus - metabolism Conspecifics Drug delivery Drug interaction Emotional behavior Excitotoxicity Macaca mulatta Male Neural networks Neurosciences Original Investigation Pharmacology/Toxicology Psychiatry Selective Serotonin Reuptake Inhibitors - administration & dosage Selective Serotonin Reuptake Inhibitors - pharmacology Serotonin Serotonin - metabolism Serotonin Antagonists - administration & dosage Serotonin Antagonists - pharmacology Serotonin S1 receptors Serotonin S2 receptors Serotonin S3 receptors Serotonin uptake inhibitors Signal Transduction - drug effects Social Behavior Social interactions
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